LEADER 03694nam 2200553Ia 450 001 9910739435403321 005 20200520144314.0 010 $a1-4614-7660-7 024 7 $a10.1007/978-1-4614-7660-3 035 $a(CKB)2670000000406485 035 $a(EBL)1398458 035 $a(SSID)ssj0000958030 035 $a(PQKBManifestationID)11516385 035 $a(PQKBTitleCode)TC0000958030 035 $a(PQKBWorkID)10985438 035 $a(PQKB)10646772 035 $a(DE-He213)978-1-4614-7660-3 035 $a(MiAaPQ)EBC1398458 035 $a(PPN)172419654 035 $a(EXLCZ)992670000000406485 100 $a20130730d2013 uy 0 101 0 $aeng 135 $aur|n|---||||| 181 $ctxt 182 $cc 183 $acr 200 00$aAdipose tissue and cancer /$fMikhail G. Kolonin, editor 205 $a1st ed. 2013. 210 $aNew York $cSpringer$d2013 215 $a1 online resource (193 p.) 300 $aDescription based upon print version of record. 311 $a1-4899-8919-6 311 $a1-4614-7659-3 320 $aIncludes bibliographical references and index. 327 $aPreface: Obesity, Adipose Tissue and Cancer Progression -- Metabolic Perturbations Associated with Adipose Tissue Dysfunction and the Obesity-Cancer Link -- Increased Adiposity and Colorectal Cancer -- Adiposity and Diabetes in Breast and Prostate Cancer -- Increased Adipocity and Endometrial Cancer Risk -- Adipokines: Soluble Factors from Adipose Tissue Implicated in Cancer -- Animal Models to Study the Interplay between Cancer and Obesity -- Unraveling the local influence of tumor-surrounding adipose tissue on tumor progression: cellular and molecular actors involved -- Trafficking of Cells from Adipose Tissue to Tumor Microenvironment -- The Impact of Obesity Intervention on Cancer: Clinical Perspectives -- Index. 330 $aThe pathophysiology underlying the relationship between obesity and cancer is complex and incompletely understood. Progression of certain cancers has been shown to accelerate in obese patients irrespective of their lifestyle and diet. Because obesity is manifested by overgrowth of white adipose tissue, it has been proposed that adipose tissue has a direct effect on cancer progression. Adipose tissue is composed of several types of cells secreting numerous soluble factors collectively termed adipokines. In addition, infiltration of the immune system cells in obesity leads to increased production of a number of inflammatory factors by adipose tissue, thus contributing to the establishment of the metabolic syndrome. Endocrine signaling by adipose tissue-derived molecules has been shown to promote cancer in animal models, matching clinical associations. Recent studies have shown that cells from adipose tissue are capable of trafficking to tumors, thus enabling paracrine action of adipokines from within the tumor microenvironment. Increased tumor vascularization, immune system suppression and direct effects on malignant cell survival and proliferation have been investigated as mechanisms regulated by adipokines. This volume will discuss clinical and experimental data pointing to the role of adipose tissue in cancer and to dissect individual mechanisms through which adipose tissue excess or restriction could influence cancer progression. 606 $aAdipose tissues 606 $aCancer 615 0$aAdipose tissues. 615 0$aCancer. 676 $a616.99407 701 $aKolonin$b Mikhail G$01755092 801 0$bMiAaPQ 801 1$bMiAaPQ 801 2$bMiAaPQ 906 $aBOOK 912 $a9910739435403321 996 $aAdipose tissue and cancer$94191720 997 $aUNINA