LEADER 03232nam 2200565Ia 450 001 9910739430803321 005 20200520144314.0 010 $a1-4614-6549-4 024 7 $a10.1007/978-1-4614-6549-2 035 $a(CKB)2550000001043799 035 $a(EBL)1205332 035 $a(SSID)ssj0000880113 035 $a(PQKBManifestationID)11454621 035 $a(PQKBTitleCode)TC0000880113 035 $a(PQKBWorkID)10872928 035 $a(PQKB)11718481 035 $a(DE-He213)978-1-4614-6549-2 035 $a(MiAaPQ)EBC1205332 035 $a(PPN)169136388 035 $a(EXLCZ)992550000001043799 100 $a20130423d2013 uy 0 101 0 $aeng 135 $aur|n|---||||| 181 $ctxt 182 $cc 183 $acr 200 00$aMolecular genetics of pancreatic cancer /$fDiane M. Simeone, Anirban Maitra, editors 205 $a1st ed. 2013. 210 $aNew York $cSpringer$dc2013 215 $a1 online resource (235 p.) 300 $a"Laboratory medicine." 311 $a1-4899-9435-1 311 $a1-4614-6548-6 320 $aIncludes bibliographical references and index. 327 $aGenomic Alterations in Sporadic Pancreatic Cancer -- Molecular Pathology of Pancreatic Cancer Precursor Lesions -- Genetic Epidemiology and Pancreatic Cancer -- Translational Implications of Molecular genetics for Early Diagnosis of Pancreatic Cancer -- The Biology of K-Ras Signaling Pathways in Pancreatic Cancer -- Molecularly Targeted Therapies in Pancreatic Cancer -- Mouse Models of Pancreatic Cancer -- Genetics of Pancreatic Cancer Metastasis -- Epigenetic Alterations in Pancreatic Cancer -- New technologies in Molecular Characterization of Pancreatic Cancer -- Index. 330 $aPancreatic cancer is a formidable disease, and advances in early detection and improved therapeutics have been slow to come forth. With new advances in molecular genetics in the field of pancreatic tumorigenesis, it is an opportune time to use these recent discoveries to enhance our understanding of pancreatic cancer biology and to improve outcomes in patients.  In this volume, leading experts in the field shed light on these findings describing the mutational landscape of pancreatic cancer, including new inroads into our understanding of familial pancreatic cancer, epidemiology, the biology of K-ras signaling, and the emerging contribution of epigenetic alterations to disease initiation and progression. The distinctive pancreatic cancer-stroma ecosystem as determined by the dynamic interplay of inflammation, hallmark mutations, EMT, and cancer stem cells is described, and implications of these interactions in the context of development of novel, personalized therapeutic options are explored. 606 $aPancreas$xCancer$xMolecular aspects 606 $aCancer$xGenetic aspects 615 0$aPancreas$xCancer$xMolecular aspects. 615 0$aCancer$xGenetic aspects. 676 $a616.99437 701 $aSimeone$b Diane M$01755090 701 $aMaitra$b Anirban$01755091 801 0$bMiAaPQ 801 1$bMiAaPQ 801 2$bMiAaPQ 906 $aBOOK 912 $a9910739430803321 996 $aMolecular genetics of pancreatic cancer$94191719 997 $aUNINA