LEADER 05010nam 22007335 450 001 9910739430703321 005 20200629235127.0 010 $a1-4614-6528-1 024 7 $a10.1007/978-1-4614-6528-7 035 $a(CKB)2550000001043798 035 $a(EBL)1205328 035 $a(SSID)ssj0000880124 035 $a(PQKBManifestationID)11484962 035 $a(PQKBTitleCode)TC0000880124 035 $a(PQKBWorkID)10872091 035 $a(PQKB)10872303 035 $a(DE-He213)978-1-4614-6528-7 035 $a(MiAaPQ)EBC1205328 035 $a(PPN)169136345 035 $a(EXLCZ)992550000001043798 100 $a20130403d2013 u| 0 101 0 $aeng 135 $aur|n|---||||| 181 $ctxt 182 $cc 183 $acr 200 10$aVesicle Trafficking in Cancer$b[electronic resource] /$fedited by Yosef Yarden, Gabi Tarcic 205 $a1st ed. 2013. 210 1$aNew York, NY :$cSpringer New York :$cImprint: Springer,$d2013. 215 $a1 online resource (393 p.) 300 $aDescription based upon print version of record. 311 $a1-4899-9496-3 311 $a1-4614-6527-3 327 $aPreface -- Clathrin Mediated Endocytosis -- Intimate And Facultative? Regulation Of Clathrin-Mediated Endocytosis By The Actin Cytoskeleton -- Oncogenic Signaling From The Plasma Membrane -- Endocytosis In The Spatial Control Of Polarized Cell Functions -- Aberrant Vesicular Trafficking Contributes To Altered Polarity And Metabolism In Cancer -- Endocytosis And The Regulation Of Cell Signaling, Cell Adhesion, And Epithelial To Mesenchymal Transition In Cancer -- Efficient Enhancement Of Signaling Capacity: Signaling Endosomes -- Nuclear Functions And Trafficking Of Receptor Tyrosine Kinases -- Efficient Enhancement Of Signaling Capacity ? The Ubiquitin System.-  Molecular Mechanism Of Ubiquitin-Dependent Traffic -- Cbl As A Master Regulator Of Receptor Tyrosine Kinase Trafficking -- Regulation Of Endocytic Trafficking And Signaling By Deubiquitylating Enzymes -- RTKs As Models For Trafficking Regulation - C-Met/HGF-Receptor- C-Met Signalling In Cancer: Location Counts -- Regulation Of Epidermal Growth Factor Receptor Signaling By Endocytosis In Normal And Malignant Cells -- Stress-Driven Endocytosis Of Tyrosine-Phosphorylated EGFR Leads To Tumorigenesis: The Critical Role Of Oxidative Stress -- Internalisation, Endosomal Trafficking And Recycling Of Integrins During Cell Migration And Cancer Invasion -- Antibody-mediated receptor endocytosis: Harnessing the cellular machinery to combat cancer -- Index. 330 $aEndocytosis and vesicular trafficking determine the landscape of the cell?s exterior, namely the density of surface molecules, such as receptors for growth factors and cytokines, adhesion molecules like integrins and cadherins, and a plethora of nutrient carriers. Hence, endocytosis is involved in signal transduction, cell adhesion and migration, as well as metabolism. To exploit these fundamental processes, malignancies subtly and multiply manipulate the endocytosis and the subsequent trafficking of protein cargoes. This is achieved by simultaneously altering the cytoskeleton, vesicle budding, cargo sorting and intracellular degradation. By highlighting the underlying molecular processes and concentrating on specific examples, this book reviews the recent emergence of derailed endocytosis and vesicular trafficking as a landmark of cancer. In-depth understanding of this common feature of tumors might lead the way to drug-induced strategies, able to rectify intracellular trafficking in cancer. 606 $aCancer research 606 $aCell biology 606 $aBiochemistry 606 $aPosttranslational modification 606 $aProteins  606 $aCancer Research$3https://scigraph.springernature.com/ontologies/product-market-codes/B11001 606 $aCell Biology$3https://scigraph.springernature.com/ontologies/product-market-codes/L16008 606 $aBiochemistry, general$3https://scigraph.springernature.com/ontologies/product-market-codes/L14005 606 $aPosttranslational Modification$3https://scigraph.springernature.com/ontologies/product-market-codes/L14090 606 $aReceptors$3https://scigraph.springernature.com/ontologies/product-market-codes/L14110 615 0$aCancer research. 615 0$aCell biology. 615 0$aBiochemistry. 615 0$aPosttranslational modification. 615 0$aProteins . 615 14$aCancer Research. 615 24$aCell Biology. 615 24$aBiochemistry, general. 615 24$aPosttranslational Modification. 615 24$aReceptors. 676 $a616.99 676 $a616.99/4 676 $a616.994071 702 $aYarden$b Yosef$4edt$4http://id.loc.gov/vocabulary/relators/edt 702 $aTarcic$b Gabi$4edt$4http://id.loc.gov/vocabulary/relators/edt 906 $aBOOK 912 $a9910739430703321 996 $aVesicle Trafficking in Cancer$93553810 997 $aUNINA