LEADER 03855nam 2200589Ia 450 001 9910739430403321 005 20200520144314.0 010 $a1-4614-6220-7 024 7 $a10.1007/978-1-4614-6220-0 035 $a(CKB)2670000000340836 035 $a(EBL)1082106 035 $a(OCoLC)836406937 035 $a(SSID)ssj0000879048 035 $a(PQKBManifestationID)11514905 035 $a(PQKBTitleCode)TC0000879048 035 $a(PQKBWorkID)10850721 035 $a(PQKB)10988830 035 $a(DE-He213)978-1-4614-6220-0 035 $a(MiAaPQ)EBC1082106 035 $a(PPN)169135942 035 $a(EXLCZ)992670000000340836 100 $a20130327d2013 uy 0 101 0 $aeng 135 $aur|n|---||||| 181 $ctxt 182 $cc 183 $acr 200 04$aThe hippo signaling pathway and cancer /$fMoshe Oren, Yael Aylon, editors 205 $a1st ed. 2013. 210 $aNew York $cSpringer$dc2013 215 $a1 online resource (344 p.) 300 $aIncludes index. 311 $a1-4939-0109-5 311 $a1-4614-6219-3 327 $aIntroduction -- Merlin and Angiomotin in Hippo-Yap signaling -- MST1/2 and other upstream signaling that affect Hippo pathway function -- YAP1 uses its modular protein domains and conserved sequence motifs to orchestrate diverse repertoires of signaling -- Regulation of YAP and TAZ transcription co-activators -- Regulation of YAP and TAZ by epithelial plasticity -- Hippo pathway and apoptosis -- YAP and p73: a matter of mutual specificity in tumour suppression -- The c-Abl/YAP/p73 apoptotic module and the Hippo pathway -- Hippo in cell cycle and mitosis -- Hippo and mouse models for cancer -- Roles of Hippo signaling during mouse embryogenesis -- Hippo Signaling and stem cells -- Hippo signaling and organ size control -- Hippo signaling in heart development -- Cell competition and the Hippo pathway -- Non-canonical roles from the Hippo pathway -- Index. 330 $aThe Hippo signaling pathway is rapidly gaining recognition as an important player in organ size control and tumorgenesis. This volume presents virtually all aspects of tumor biology because members of the Hippo Pathway have been associated with numerous well-established cell signaling pathways, just to name a few; Rho, Wnt, TGFbeta and p53. Hippo signaling is not solely involved in regulating ?classic? tumor characteristics such as cell proliferation, survival and growth, but is also diversely involved in cell-autonomous and non-cell-autonomous differentiation, migration and organ size control. With the multitude of signaling events mediated by the Hippo pathway and the vastly different functions that it plays, it is evident that these tumor suppressors are unique governors of cellular homeostasis. This timely volume gathers wide-ranging and burgeoning information on the Hippo pathway and its role in cancer into an accessible format of a single book.With the multitude of signaling events mediated by the Hippo pathway and the vastly different functions that it plays, it is evident that these tumor suppressors are unique governors of cellular homeostasis. This timely volume gathers wide-ranging and burgeoning information on the Hippo pathway and its role in cancer into an accessible format of a single book. 606 $aCancer$xGenetic aspects 606 $aCellular signal transduction 606 $aCancer$xMolecular aspects 615 0$aCancer$xGenetic aspects. 615 0$aCellular signal transduction. 615 0$aCancer$xMolecular aspects. 676 $a616.994071 701 $aOren$b Moshe$01761255 701 $aAylon$b Yael$01761256 801 0$bMiAaPQ 801 1$bMiAaPQ 801 2$bMiAaPQ 906 $aBOOK 912 $a9910739430403321 996 $aThe hippo signaling pathway and cancer$94200583 997 $aUNINA