LEADER 00768nam0-2200277 --450 001 9910505309103321 005 20211112140229.0 010 $a978-88-481-4146-8 100 $a20211112d2020----kmuy0itay5050 ba 101 0 $aita 102 $aIT 105 $aa 001yy 200 1 $a<>microbiota$ela chiave della nostra salute$fBruno Brigo 210 $aMilano$cTecniche nuove$d2020 215 $a183 p.$cill.$d21 cm 225 1 $aNatura e salute 610 0 $aMicrobiota intestinale 676 $a612.33$v23$zita 700 1$aBrigo,$bBruno$0312349 801 0$aIT$bUNINA$gREICAT$2UNIMARC 901 $aBK 912 $a9910505309103321 952 $a60 612.33 BRIB 2020$b685/2021$fFAGBC 959 $aFAGBC 996 $aMicrobiota$91977326 997 $aUNINA LEADER 03085nam 2200553Ia 450 001 9910739427003321 005 20200520144314.0 010 $a1-4614-6498-6 024 7 $a10.1007/978-1-4614-6498-3 035 $a(CKB)2670000000369978 035 $a(EBL)1205324 035 $a(SSID)ssj0000880122 035 $a(PQKBManifestationID)11956614 035 $a(PQKBTitleCode)TC0000880122 035 $a(PQKBWorkID)10873298 035 $a(PQKB)10635394 035 $a(DE-He213)978-1-4614-6498-3 035 $a(MiAaPQ)EBC1205324 035 $a(PPN)169136299 035 $a(EXLCZ)992670000000369978 100 $a20130422d2013 uy 0 101 0 $aeng 135 $aur|n|---||||| 181 $ctxt 182 $cc 183 $acr 200 00$aStem cells and prostate cancer /$fScott D. Cramer, editor 205 $a1st ed. 2013. 210 $aNew York $cSpringer$dc2013 215 $a1 online resource (182 p.) 300 $aIncludes index. 311 $a1-4939-0094-3 311 $a1-4614-6497-8 327 $aPreface -- Stem Cells and Prostate Development -- Isolation and Characterization of Prostate Stem Cells -- Prostate tumor initiating cells -- TIC Markers and methods of characterization -- Genetic Control of Self Renewal of the TIC -- Therapeutic targeting of the prostate TIC.- The prostate stem cell niche.- Tumor stroma control of the prostate TIC.- Targeting the prostate stem cell for chemoprevention.- Stem cell models for functional validation of prostate cancer genes -- Index . 330 $aRecent evidence demonstrates that normal prostate tissue contains stem cells.  There is also accumulating evidence that prostate cancer contains a population of cells with stem cell-like characteristics referred to as cancer stem cells, or tumor initiating cells.  Both the normal prostate stem cell and cancer stem cell populations have important implications for the generation, therapeutic targeting, and prevention of prostate cancer.  This book will explore the role of stem cells in normal prostate development and prostate cancer, methods for isolation and characterization of normal prostate stem cells and prostate tumor initiating cells, the functional relationship between normal stem cells and prostate tumor initiating cells, the relationship of prostate cancer genetics and self-renewal and differentiation, the prostate stem cell as a target for therapeutics and prevention, and the utility of stem cells for prostate cancer models.  This book synthesizes these concepts and more into a single volume accessible to basic and translational researchers in prostate cancer and beyond. 606 $aProstate$xCancer$xGenetic aspects 606 $aStem cells 615 0$aProstate$xCancer$xGenetic aspects. 615 0$aStem cells. 676 $a616.99 676 $a616.99/463 701 $aCramer$b Scott D$01755089 801 0$bMiAaPQ 801 1$bMiAaPQ 801 2$bMiAaPQ 906 $aBOOK 912 $a9910739427003321 996 $aStem cells and prostate cancer$94191718 997 $aUNINA