LEADER 02822nam 2200493 a 450 001 9910739405903321 005 20200520144314.0 010 $a3-642-37999-0 024 7 $a10.1007/978-3-642-37999-4 035 $a(OCoLC)852664400 035 $a(MiFhGG)GVRL6VBN 035 $a(CKB)2670000000403422 035 $a(MiAaPQ)EBC1317689 035 $a(EXLCZ)992670000000403422 100 $a20130605d2013 uy 0 101 0 $aeng 135 $aurun|---uuuua 181 $ctxt 182 $cc 183 $acr 200 00$aDisruption of protein-protein interfaces $ein search of new inhibitors /$fStefano Mangani, editor 205 $a1st ed. 2013. 210 $aNew York $cSpringer$d2013 215 $a1 online resource (vii, 161 pages) $cillustrations (some color) 225 0 $aGale eBooks 300 $aDescription based upon print version of record. 311 $a3-642-43389-8 311 $a3-642-37998-2 320 $aIncludes bibliographical references and index. 327 $aDrug discovery by targeting protein-protein interactions -- Protein-Protein Interaction Inhibitors: case studies on small molecules and natural compounds -- Disrupting Protein-Protein Interfaces using GRID Molecular Interaction Fields -- NMR as a tool to target protein-protein interactions -- Protein-protein interactions in the solid state The troubles of crystallizing of protein- protein complexes -- Fluorescence observables and enzyme kinetics in the investigation of PPI modulation by small molecules Detection, mechanistic insight, functional consequences. 330 $a"Disruption of Protein-Protein Interfaces" reviews the latest developments and future perspectives in drug discovery at protein-protein interfaces, as well as including details of experimental and computational tools to tackle the subject, and highlighting the contribution of the Italian research community to the field. Evidence shows that blocking or modulating protein-protein interactions might lead to the development of useful new drugs. Consequently, in recent years great effort has been dedicated to unveiling the molecular details of protein-protein interfaces by structural techniques e.g. X-ray diffraction, NMR spectroscopy. This book, written and edited by leaders in the field, provides examples from the literature of successes and failures to develop drug-like molecules effective in interacting at protein-protein interfaces. 606 $aProtein-protein interactions 615 0$aProtein-protein interactions. 676 $a54 676 $a547 676 $a547.7 701 $aMangani$b Stefano$0498471 801 0$bMiAaPQ 801 1$bMiAaPQ 801 2$bMiAaPQ 906 $aBOOK 912 $a9910739405903321 996 $aDisruption of protein-protein interfaces$94187487 997 $aUNINA