LEADER 04801nam 22006015 450 001 9910737300203321 005 20200702072237.0 010 $a3319585924$b(electronic bk.) 010 $a9783319585925$b(electronic bk.) 010 $z3319585916 024 7 $a10.1007/978-3-319-58592-5 035 $a(CKB)3710000001631526 035 $a(DE-He213)978-3-319-58592-5 035 $a(MiAaPQ)EBC4987087 035 $a(PPN)203850777 035 $a(EXLCZ)993710000001631526 100 $a20170824d2017 u| 0 101 0 $aeng 135 $aurnn|008mamaa 181 $ctxt$2rdacontent 182 $cc$2rdamedia 183 $acr$2rdacarrier 200 10$aCentromeres and Kinetochores$b[electronic resource] $eDiscovering the Molecular Mechanisms Underlying Chromosome Inheritance /$fedited by Ben E. Black 205 $a1st ed. 2017. 210 1$aCham :$cSpringer International Publishing :$cImprint: Springer,$d2017. 215 $a1 online resource (XI, 554 p. 101 illus., 98 illus. in color.) 225 1 $aProgress in Molecular and Subcellular Biology,$x0079-6484 ;$v56 311 $aPrint version available : Centromeres and kinetochores 3-319-58591-6 320 $aIncludes bibliographical references at the end of each chapters. 327 $aPreface -- Use of Mass Spectrometry to Study the Centromere and Kinetochore -- Critical Foundation of the Kinetochore: the Constitutive Centromere Associated Network (CCAN) -- The Power of Xenopus Egg Extract for Reconstitution of Centromere and Kinetochore Function -- Centrochromatin of Fungi -- Evolutionary Lessons from Species with Unique Kinetochores.-Quantitative Microscopy Reveals Centromeric Chromatin Stability, Size, and Cell Cycle Mechanisms to Maintain Centromere Homeostasis -- Orchestrating the Specific Assembly of Centromeric Nucleosomes -- Artificial Chromosomes and Strategies to Initiate Epigenetic Centromere Establishment -- Post-translational Modifications of Centromeric Chromatin -- Centromere Silencing Mechanisms -- Centromere Transcription: Means and Motive -- The Promises and Challenges of Genomic Studies of Human Centromeres -- DNA Sequences in Centromere Formation and Function -- The Unique DNA Sequences Underlying Equine Centromeres -- Centromere Dynamics in Male and Female Germ Cells -- Cell Biology of Cheating?Transmission of Centromeres and Other Selfish Elements Through Asymmetric Meiosis -- Biophysics of Microtubule End Coupling at the Kinetochore -- Molecular Mechanisms of Spindle Assembly Checkpoint Activation and Silencing -- A Kinase-Phosphatase Network That Regulates Kinetochore-Microtubule Attachments and the SAC -- Centromeric Cohesion: Molecular Glue and Much More -- Centromere Structure and Function -- The Role of Centromere Defects in Cancer. 330 $aThis book presents the latest advances concerning the regulation of chromosome segregation during cell division by means of centromeres and kinetochores. The authors cover both state-of-the-art techniques and a range of species and model systems, shedding new light on the molecular mechanisms controlling the transmission of genetic material between cell divisions and from parent to offspring. The chapters cover five major areas related to the current study of centromeres and kinetochores: 1) their genetic and epigenetic features, 2) key breakthroughs at the molecular, proteomic, imaging and biochemical level, 3) the constitutive centromere proteins, 4) the role of centromere proteins in the physical process of chromosome segregation and its careful orchestration through elaborate regulation, and 5) intersections with reproductive biology, human health and disease, as well as chromosome evolution. The book offers an informative and provocative guide for newcomers as well as those already acquainted with the field. 410 0$aProgress in Molecular and Subcellular Biology,$x0079-6484 ;$v56 606 $aCell cycle 606 $aCell physiology 606 $aHuman genetics 606 $aCell Cycle Analysis$3https://scigraph.springernature.com/ontologies/product-market-codes/L16030 606 $aCell Physiology$3https://scigraph.springernature.com/ontologies/product-market-codes/L33010 606 $aHuman Genetics$3https://scigraph.springernature.com/ontologies/product-market-codes/B12008 615 0$aCell cycle. 615 0$aCell physiology. 615 0$aHuman genetics. 615 14$aCell Cycle Analysis. 615 24$aCell Physiology. 615 24$aHuman Genetics. 676 $a571.844 702 $aBlack$b Ben E$4edt$4http://id.loc.gov/vocabulary/relators/edt 801 0$bMiAaPQ 801 1$bMiAaPQ 801 2$bMiAaPQ 906 $aBOOK 912 $a9910737300203321 996 $aCentromeres and Kinetochores$93459250 997 $aUNINA