LEADER 03914nam 22007095 450 001 9910737300003321 005 20240117111757.0 010 $a3-030-67696-X 024 7 $a10.1007/978-3-030-67696-4 035 $a(CKB)4100000011949945 035 $a(MiAaPQ)EBC6633344 035 $a(Au-PeEL)EBL6633344 035 $a(OCoLC)1253475912 035 $a(DE-He213)978-3-030-67696-4 035 $a(PPN)255881983 035 $a(EXLCZ)994100000011949945 100 $a20210529d2021 u| 0 101 0 $aeng 135 $aurcnu|||||||| 181 $ctxt$2rdacontent 182 $cc$2rdamedia 183 $acr$2rdacarrier 200 10$aCellular Biology of the Endoplasmic Reticulum /$fedited by Luis B. Agellon, Marek Michalak 205 $a1st ed. 2021. 210 1$aCham :$cSpringer International Publishing :$cImprint: Springer,$d2021. 215 $a1 online resource (329 pages) 225 1 $aProgress in Molecular and Subcellular Biology,$x2197-8484 ;$v59 311 $a3-030-67695-1 327 $aA View of the Endoplasmic Reticulum Through the Calreticulin Lens -- Structural Analysis of Calreticulin, an Endoplasmic Reticulum-Resident Molecular Chaperone -- The Role of Endoplasmic Reticulum Chaperones in Protein Folding and Quality Control -- Proteins Interacting with STIM1 and Store-Operated Ca2+ Entry -- Endoplasmic Reticulum (ER) and ER-Phagy -- Defects in Protein Folding and/or Quality Control Cause Protein Aggregation in the Endoplasmic Reticulum -- Roles of Calreticulin in Protein Folding, Immunity, Calcium Signaling and Cell Transformation -- Impact of Calreticulin and Its Mutants on Endoplasmic Reticulum Function in Health and Disease -- Cancer Biology of the Endoplasmic Reticulum Lectin Chaperones Calreticulin, Calnexin and PDIA3/ERp57 -- Maintenance of Endoplasmic Reticulum Protein Homeostasis in Cancer: Friend or Foe -- IP3 Receptor Biology and Endoplasmic Reticulum Calcium Dynamics in Cancer -- Disruption of Endoplasmic Reticulum Proteostasis in Age-Related Nervous System Disorders -- Endoplasmic Reticulum Homeostasis and Stress Responses in Caenorhabditis elegans -- Tardigrada: An Emerging Animal Model to Study the Endoplasmic Reticulum Stress Response to Environmental Extremes. . 330 $aThis book provides a comprehensive overview of the biology of the endoplasmic reticulum (ER) and the associated ER proteins, it discusses their structure, function and signaling mechanisms in the cell and their role in disease. This book also offers insights into the practical aspects of research and demonstrates the use of non-mammalian models to study the structure and function of the ER. Written by leading experts in the field, the book enables readers to gain a thorough understanding of current ER biology. It is intended for scientists and clinical researchers working on the endoplasmic reticulum in all its various roles and facets in health and disease. . 410 0$aProgress in Molecular and Subcellular Biology,$x2197-8484 ;$v59 606 $aCytology 606 $aCancer 606 $aImmunology 606 $aNeurology 606 $aCell Biology 606 $aCancer Biology 606 $aImmunology 606 $aNeurology 606 $aReticle endoplasmātic$2thub 606 $aCitologia$2thub 608 $aLlibres electrōnics$2thub 615 0$aCytology. 615 0$aCancer. 615 0$aImmunology. 615 0$aNeurology. 615 14$aCell Biology. 615 24$aCancer Biology. 615 24$aImmunology. 615 24$aNeurology. 615 7$aReticle endoplasmātic 615 7$aCitologia 676 $a571.65 702 $aAgellon$b Luis B. 702 $aMichalak$b Marek 801 0$bMiAaPQ 801 1$bMiAaPQ 801 2$bMiAaPQ 906 $aBOOK 912 $a9910737300003321 996 $aCellular biology of the endoplasmic reticulum$93459248 997 $aUNINA