LEADER 03513nam 22006135 450 001 9910737299203321 005 20230810194832.0 010 $a3-319-96704-5 024 7 $a10.1007/978-3-319-96704-2 035 $a(CKB)4100000005679122 035 $a(MiAaPQ)EBC5491593 035 $a(DE-He213)978-3-319-96704-2 035 $a(PPN)229916732 035 $a(EXLCZ)994100000005679122 100 $a20180810d2018 u| 0 101 0 $aeng 135 $aurcnu|||||||| 181 $ctxt$2rdacontent 182 $cc$2rdamedia 183 $acr$2rdacarrier 200 10$aEndocytosis and Signaling /$fedited by Christophe Lamaze, Ian Prior 205 $a1st ed. 2018. 210 1$aCham :$cSpringer International Publishing :$cImprint: Springer,$d2018. 215 $a1 online resource (332 pages) 225 1 $aProgress in Molecular and Subcellular Biology,$x2197-8484 ;$v57 311 $a3-319-96703-7 327 $aPreface -- The endosomal network: mediators and regulators of endosome maturation -- Integration of the endocytic system into the network of cellular functions -- GTPases Rac1 and Ras signaling from endosomes -- ESCRT and membrane protein ubiquitination -- Retromer and it?s role in regulating signaling at endosomes -- The lysosome and intracellular signaling -- Interplay of endocytosis and growth factor receptor signaling -- Role of the endocytosis of caveolae in intracellular signaling and metabolism -- EGFR trafficking in physiology and cancer -- Evolving view of membrane trafficking and signaling systems for G protein-coupled receptors -- Endosomal trafficking during mitosis and Notch-dependent asymmetric division. 330 $aThis book focuses on the context dependency of cell signaling by showing how the endosomal system helps to structure and regulate signaling pathways. The location and concentration of signaling nodes regulate their activation cycles and engagement with distinct effector pathways. Whilst many cell signaling pathways are initiated from the cell surface, endocytosis provides an opportunity for modulating signaling networks? output. In this book, first a series of reviews describe the endocytic and endosomal system and show how these subcellular platforms sort and regulate a wide range of signaling pathway components and phenotypic outputs. The book then reviews the latest scientific insights into how endocytic trafficking and subcellular location modulate a set of major pathways that are essential to normal cellular function and organisms? development. . 410 0$aProgress in Molecular and Subcellular Biology,$x2197-8484 ;$v57 606 $aBiological transport 606 $aCell membranes 606 $aCytology 606 $aCytology$xTechnique 606 $aProteins 606 $aMembrane Trafficking 606 $aCell Biology 606 $aCytological Techniques 606 $aProtein Biochemistry 615 0$aBiological transport. 615 0$aCell membranes. 615 0$aCytology. 615 0$aCytology$xTechnique. 615 0$aProteins. 615 14$aMembrane Trafficking. 615 24$aCell Biology. 615 24$aCytological Techniques. 615 24$aProtein Biochemistry. 676 $a571.6 702 $aLamaze$b Christophe$4edt$4http://id.loc.gov/vocabulary/relators/edt 702 $aPrior$b Ian$4edt$4http://id.loc.gov/vocabulary/relators/edt 906 $aBOOK 912 $a9910737299203321 996 $aEndocytosis and Signaling$93459241 997 $aUNINA