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001 9910737299203321
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010   $a3-319-96704-5
024 7 $a10.1007/978-3-319-96704-2
035   $a(CKB)4100000005679122
035   $a(MiAaPQ)EBC5491593
035   $a(DE-He213)978-3-319-96704-2
035   $a(PPN)229916732
035   $a(EXLCZ)994100000005679122
100   $a20180810d2018      u|             0
101 0 $aeng
135   $aurcnu||||||||
181   $ctxt$2rdacontent
182   $cc$2rdamedia
183   $acr$2rdacarrier
200 10$aEndocytosis and Signaling$b[electronic resource] /$fedited by Christophe Lamaze, Ian Prior
205   $a1st ed. 2018.
210  1$aCham :$cSpringer International Publishing :$cImprint: Springer,$d2018.
215   $a1 online resource (332 pages)
225 1 $aProgress in Molecular and Subcellular Biology,$x0079-6484 ;$v57
311   $a3-319-96703-7 
327   $aPreface -- The endosomal network: mediators and regulators of endosome maturation -- Integration of the endocytic system into the network of cellular functions -- GTPases Rac1 and Ras signaling from endosomes -- ESCRT and membrane protein ubiquitination -- Retromer and it?s role in regulating signaling at endosomes -- The lysosome and intracellular signaling -- Interplay of endocytosis and growth factor receptor signaling -- Role of the endocytosis of caveolae in intracellular signaling and metabolism -- EGFR trafficking in physiology and cancer -- Evolving view of membrane trafficking and signaling systems for G protein-coupled receptors -- Endosomal trafficking during mitosis and Notch-dependent asymmetric division.
330   $aThis book focuses on the context dependency of cell signaling by showing how the endosomal system helps to structure and regulate signaling pathways. The location and concentration of signaling nodes regulate their activation cycles and engagement with distinct effector pathways. Whilst many cell signaling pathways are initiated from the cell surface, endocytosis provides an opportunity for modulating signaling networks? output. In this book, first a series of reviews describe the endocytic and endosomal system and show how these subcellular platforms sort and regulate a wide range of signaling pathway components and phenotypic outputs. The book then reviews the latest scientific insights into how endocytic trafficking and subcellular location modulate a set of major pathways that are essential to normal cellular function and organisms? development. .
410  0$aProgress in Molecular and Subcellular Biology,$x0079-6484 ;$v57
606   $aCell membranes 
606   $aCell physiology
606   $aCell cycle
606   $aProteins 
606   $aMembrane Biology$3https://scigraph.springernature.com/ontologies/product-market-codes/L16050
606   $aCell Physiology$3https://scigraph.springernature.com/ontologies/product-market-codes/L33010
606   $aCell Cycle Analysis$3https://scigraph.springernature.com/ontologies/product-market-codes/L16030
606   $aProtein Science$3https://scigraph.springernature.com/ontologies/product-market-codes/L14040
615  0$aCell membranes .
615  0$aCell physiology.
615  0$aCell cycle.
615  0$aProteins .
615 14$aMembrane Biology.
615 24$aCell Physiology.
615 24$aCell Cycle Analysis.
615 24$aProtein Science.
676   $a571.6
702   $aLamaze$b Christophe$4edt$4http://id.loc.gov/vocabulary/relators/edt
702   $aPrior$b Ian$4edt$4http://id.loc.gov/vocabulary/relators/edt
906   $aBOOK
912   $a9910737299203321
996   $aEndocytosis and Signaling$93459241
997   $aUNINA