LEADER 05278nam 2200565 a 450 001 9910737298903321 005 20250701235257.0 010 $a94-007-6889-3 024 7 $a10.1007/978-94-007-6889-5 035 $a(CKB)2670000000403988 035 $a(EBL)1317761 035 $a(OCoLC)852839815 035 $a(SSID)ssj0000958067 035 $a(PQKBManifestationID)11531622 035 $a(PQKBTitleCode)TC0000958067 035 $a(PQKBWorkID)10985039 035 $a(PQKB)11604898 035 $a(DE-He213)978-94-007-6889-5 035 $a(MiAaPQ)EBC1317761 035 $a(PPN)172433673 035 $a(EXLCZ)992670000000403988 100 $a20130620d2013 uy 0 101 0 $aeng 135 $aur|n|---||||| 181 $ctxt 182 $cc 183 $acr 200 00$aPeroxisomes and their key role in cellular signaling and metabolism /$fLuis A. del Rio, editor 205 $a1st ed. 2013. 210 $aNew York $cSpringer$d2013 215 $a1 online resource (352 p.) 225 1 $aSub-cellular biochemistry,$x0306-0225 ;$vv. 69 300 $aDescription based upon print version of record. 311 08$a94-017-8290-3 311 08$a94-007-6888-5 320 $aIncludes bibliographical references and index. 327 $aPeroxisome interactions and cross-talk with other subcellular compartments in animal cells -- Peroxisomes in human health and disease: metabolic pathways, metabolite transport, interplay with other organelles and signal transduction -- Aging, age-related diseases and peroxisomes -- Peroxisomes and the antiviral responses of mammalian cells -- Peroxisome proliferator-activated receptor-? signaling in hepatocarcinogenesis -- Involvement of human peroxisomes in biosynthesis and signaling of steroid and peptide hormones -- Peroxisome Ca2+ homeostasis in animal and plant cells -- The versatility of peroxisome function in filamentous fungi -- Essential roles of peroxisomally produced and metabolized biomolecules in regulating yeast longevity -- Metabolite transporters of the plant peroxisomal membrane - known and unknown -- Peroxisomes and photomorphogenesis -- Biosynthesis of vitamin K1 (phylloquinone) by plant peroxisomes and its integration into signaling molecule synthesis pathways -- Role of peroxisomes as a source of reactive oxygen species (ROS) signaling molecules -- Peroxisomes as a source of auxin signaling molecules -- Peroxisomes as cell generators of reactive nitrogen species (RNS) signal molecules -- Role of plant peroxisomes in the production of jasmonic acid-based signals -- Role of plant peroxisomes in protection against herbivores -- Function of Peroxisomes in Plant-Pathogen Interactions. 330 $aPeroxisomes are a class of ubiquitous and dynamic single membrane-bounded cell organelles, devoid of DNA, with an essentially oxidative type of metabolism. Today it is known that fatty acid ?-oxidation is a general feature of virtually all types of peroxisomes, but in higher eukaryotes, including humans, peroxisomes catalyze ether phospholipids biosynthesis, fatty acid ?-oxidation, and glyoxylate detoxification, and in humans peroxisomes are associated with several important genetic diseases. Among the different new roles for human peroxisomes discovered in recent years are antiviral innate immunity, peptide hormone metabolism, brain aging and Alzheimer?s disease, and age-related diseases. In fungi, new findings have broadened the number of secondary metabolites that are synthesized in peroxisomes, such as antibiotics and several toxins, and have evidenced their involvement in biotin biosynthesis, fungal development and plant pathogenesis. In plants, peroxisomes carry out different functions, apart from fatty acid ?-oxidation, mainly including photorespiration, metabolism of reactive oxygen, nitrogen and sulfur species, photomorphogenesis, biosynthesis of phytohormones, senescence, and defense against pathogens and hervibores. Two important characteristics of peroxisomes are their metabolic plasticity and capacity of sharing metabolic pathways with other cell compartments. In recent years, a function for peroxisomes as key centers of the cellular-signaling apparatus which could influence the regulatory network of the cell has been postulated. The diverse key physiological functions that have been demonstrated for peroxisomes from different origins strongly indicate the interest of studying the role of peroxisomes as a cellular source of different signaling molecules. This book presents recent advances in the function and metabolism of peroxisomes from human, animal, fungal and plant origin and their metabolic interconnection with other cell compartments, showing the central role played by peroxisomes as cell generators of different signaling molecules involved in distinct processes of high physiological importance. 410 0$aSub-cellular biochemistry,$x2542-8810 ;$vv. 69. 606 $aPeroxisomes 615 0$aPeroxisomes. 676 $a571.655 701 $aRio$b Luis A. del$01752238 801 0$bMiAaPQ 801 1$bMiAaPQ 801 2$bMiAaPQ 906 $aBOOK 912 $a9910737298903321 996 $aPeroxisomes and their key role in cellular signaling and metabolism$94187498 997 $aUNINA