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010   $a981-9931-85-1
024 7 $a10.1007/978-981-99-3185-9
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035   $a(Au-PeEL)EBL30667428
035   $a(DE-He213)978-981-99-3185-9
035   $a(PPN)272257133
035   $a(CKB)27865547100041
035   $a(EXLCZ)9927865547100041
100   $a20230726d2023      u|         0
101 0 $aeng
135   $aurcnu||||||||
181   $ctxt$2rdacontent
182   $cc$2rdamedia
183   $acr$2rdacarrier
200 10$aCancer Stem Cells: Basic Concept and Therapeutic Implications /$fedited by Farhadul Islam, Alfred K. Lam
205   $a1st ed. 2023.
210  1$aSingapore :$cSpringer Nature Singapore :$cImprint: Springer,$d2023.
215   $a1 online resource (375 pages)
311 08$aPrint version: Islam, Farhadul Cancer Stem Cells: Basic Concept and Therapeutic Implications Singapore : Springer Singapore Pte. Limited,c2023 9789819931842 
327   $a1. Introduction and perspective in carcinogenesis -- 2. Origin and Development of Cancer Stem Cells -- 3. Detection and Isolation of Cancer Stem Cells -- 4. The genetic and epigenetic landscape of cancer stem cells -- 5. Metabolism of Cancer Stem Cell -- 6. Plasticity of Cancer Stem Cell -- 7. Cancer Stem Cells in Cancer Initiation and Progression -- 8. Cancer Stem Cells and Metastasis -- 9. Roles of Cancer Stem Cells in Therapy resistance and Disease Recurrence -- 10. Novel therapeutics targeting cancer stem cell surface markers -- 11. Therapeutics targeting cancer stem cells signalling pathways -- 12. Cancer stem cells therapeutics delivery and EPR effect -- 13. Immunotherapy against cancer stem cells -- 14. Engineering nanobody targeting cancer stem cells -- 15. Biological barriers for drug delivery to cancer stem cells -- 16. Cancer Stem Cell Markers in Haematological Malignancies -- 17. Diagnostic and Prognostic Significance of Cancer Stem Cells Surface Markers -- 18. Diagnostic and prognostic implications of cancer stem cells transcription factors -- 19. Diagnostic and prognostic significance of intracellular markers of CSCs in patients with cancers. .
330   $aThis book comprehensively reviews the role of cancer stem cells (CSCs) in cancer initiation, progression, and resistance to anticancer therapies. The initial chapters examine the methods and procedure of the detection, isolation, and characterization of CSCs. It also introduces various epigenetic pathways that contribute to cancer initiation and tumorigenesis, particularly regarding the maintenance and survival of CSCs. It also explores the role of CSCs metabolism and the mechanisms of metabolic plasticity of CSCs in cancer biology. Further, it also presents the implications of CSCs on the origin of tumor heterogeneity and on heterogeneity of the therapeutic response. Towards the end, this book highlights the different immunotherapeutic approaches targeting CSCs with the potential of strongly improving cancer outcomes. This book offers a broad framework to scientists and clinicians into the state-of-the-art knowledge on cancer stem cell biology and highlights their therapeutic implications.
606   $aCancer
606   $aStem cells
606   $aCancer?Treatment
606   $aCancer?Genetic aspects
606   $aCancer Stem Cells
606   $aCancer Therapy
606   $aCancer Biology
606   $aCancer Genetics and Genomics
615  0$aCancer.
615  0$aStem cells.
615  0$aCancer?Treatment.
615  0$aCancer?Genetic aspects.
615 14$aCancer Stem Cells.
615 24$aCancer Therapy.
615 24$aCancer Biology.
615 24$aCancer Genetics and Genomics.
676   $a616.99407
700   $aIslam$b Farhadul$01380459
701   $aLam$b Alfred K$01380460
801  0$bMiAaPQ
801  1$bMiAaPQ
801  2$bMiAaPQ
906   $aBOOK
912   $a9910736002703321
996   $aCancer stem cells$93421894
997   $aUNINA