LEADER 01171nam--2200397---450- 001 990003002500203316 005 20071030151652.0 010 $a2-86958-034-7 035 $a000300250 035 $aUSA01000300250 035 $a(ALEPH)000300250USA01 035 $a000300250 100 $a20071030d1990----km-y0itay50------ba 101 $afre 102 $aGR 105 $aa---||||001yy 200 1 $a<> hilotes$fpar J. Ducat 210 $aAthènes$cÉcole française d'Athènes$d1990 215 $aVIII, 212 p.$d26 cm. 225 2 $aBulletin de correspondance hellénique$iSupplément$v20 410 0$12001$aBulletin de correspondance hellénique$iSupplément$v20 454 1$12001 461 1$1001-------$12001 606 0 $aIloti$xStoria$xFonti 606 0 $aSparta$xStoria sociale$xFonti 676 $a305.560938 700 1$aDUCAT,$bJean$0205168 801 0$aIT$bsalbc$gISBD 912 $a990003002500203316 951 $aIX.3. 546$b199766 L.M.$cIX.3.$d00162029 959 $aBK 969 $aUMA 979 $aRIVELLI$b90$c20071030$lUSA01$h1515 979 $aRIVELLI$b90$c20071030$lUSA01$h1516 996 $aHilotes$977913 997 $aUNISA LEADER 04329nam 22006855 450 001 9910735790303321 005 20251008150517.0 010 $a3-031-33325-X 024 7 $a10.1007/978-3-031-33325-5 035 $a(MiAaPQ)EBC30666715 035 $a(Au-PeEL)EBL30666715 035 $a(DE-He213)978-3-031-33325-5 035 $a(PPN)27225049X 035 $a(CKB)27861142600041 035 $a(EXLCZ)9927861142600041 100 $a20230724d2023 u| 0 101 0 $aeng 135 $aurcnu|||||||| 181 $ctxt$2rdacontent 182 $cc$2rdamedia 183 $acr$2rdacarrier 200 10$aGenome Editing in Biomedical Sciences /$fedited by Geraldo A. Passos 205 $a1st ed. 2023. 210 1$aCham :$cSpringer International Publishing :$cImprint: Springer,$d2023. 215 $a1 online resource (216 pages) 225 1 $aAdvances in Experimental Medicine and Biology,$x2214-8019 ;$v1429 311 08$aPrint version: Passos, Geraldo A. Genome Editing in Biomedical Sciences Cham : Springer International Publishing AG,c2023 9783031333248 327 $aWhat is the CRISPR system and how it is used? -- Modern approaches to mouse genome editing using the CRISPR-Cas toolbox and their applications in functional genomics and translational research -- Long Non-Coding RNAs and Crispr-Cas edition in Tumorigenesis -- The Crispr/Cas system in human cancer -- Using CRISPR/Cas9 to Edit a Thyroid Cancer Cell Line -- Genome editing for engineering the next generation of advanced immune cell therapies -- CRISPR Genome Editing and the Study of Chagas Disease -- Genome Editing Tools for Lysosomal Storage Disorders -- CRISPR Libraries and Whole-Genome Screening to Identify Factors for Viral Infections -- Gene Editing Technologies Targeting TFAM and its Relation to Mitochondrial Diseases -- The Gene-Edited Babies Controversy: Reactions in the Scientific Community, Social Media, and the Press -- Index. 330 $aThis volume focuses on applying the Crispr system in editing the genome of human cells (in vitro and in vivo) and model organisms used in biomedical research. With the advent of Crispr technology, genome editing soon became a procedure of great interest to laboratories worldwide due to its relative ease and accuracy. In biomedical sciences, genome editing by Crispr has already enabled the development of new experimental model systems. In medicine, therapeutic alternatives for the genetic "correction" of diseases have already begun to appear. Therefore, the book's purpose is to bring in a single volume, chapters that show the scientific community in biomedicine, medicine, human genetics, oncology, virology, and parasitology, among others, the advances in genomic editing. In a chapter dedicated to the ethical aspects of human genomic editing, we also address what we can and should do with this (bio)technology. The book chapters were written by productive researchers specializing in Crispr genome editing. The chapters cover the concept of Crispr and genome editing and how to use this new methodology in biomedical research and medicine, among other aspects, including the ethical controversy around its use in humans. The writing of the chapters keeps a specialized language intelligible enough for those who want to introduce themselves to the subject. 410 0$aAdvances in Experimental Medicine and Biology,$x2214-8019 ;$v1429 606 $aGenetics 606 $aGenomics 606 $aCancer$xGenetic aspects 606 $aEpigenetics 606 $aMedical genetics 606 $aGenetics and Genomics 606 $aGenomics 606 $aCancer Genetics and Genomics 606 $aEpigenetics 606 $aMedical Genetics 615 0$aGenetics. 615 0$aGenomics. 615 0$aCancer$xGenetic aspects. 615 0$aEpigenetics. 615 0$aMedical genetics. 615 14$aGenetics and Genomics. 615 24$aGenomics. 615 24$aCancer Genetics and Genomics. 615 24$aEpigenetics. 615 24$aMedical Genetics. 676 $a576.5 676 $a576.5072 700 $aPassos$b Geraldo A$01379197 801 0$bMiAaPQ 801 1$bMiAaPQ 801 2$bMiAaPQ 906 $aBOOK 912 $a9910735790303321 996 $aGenome Editing in Biomedical Sciences$93418673 997 $aUNINA