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010   $a981-9911-83-4
024 7 $a10.1007/978-981-99-1183-7
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035   $a(Au-PeEL)EBL30661184
035   $a(DE-He213)978-981-99-1183-7
035   $a(PPN)272255939
035   $a(CKB)27704119300041
035   $a(EXLCZ)9927704119300041
100   $a20230720d2023      u|         0
101 0 $aeng
135   $aurcnu||||||||
181   $ctxt$2rdacontent
182   $cc$2rdamedia
183   $acr$2rdacarrier
200 10$aTumor Ecosystem $eAn Ecological View of Cancer Growth and Survival /$fedited by Erwei Song
205   $a1st ed. 2023.
210  1$aSingapore :$cSpringer Nature Singapore :$cImprint: Springer,$d2023.
215   $a1 online resource (697 pages)
311 08$aPrint version: Song, Erwei Tumor Ecosystem Singapore : Springer,c2023 9789819911820 
320   $aIncludes bibliographical references.
327   $aChapter 1: Interactions in cancer ecosystem -- Chapter 2: Local niche construction -- Chapter 3: Pre-metastatic niche -- Chapter 4: Emerging concepts in cluster metastasis -- Chapter 5: Neuronal regulation in cancer ecosystem -- Chapter 6: Endocrinal regulation in cancer ecosystem -- Chapter 7: Innate immune system in cancer ecosystem -- Chapter 8: Adaptive immune system in cancer ecosystem -- Chapter 9: Inflammation in cancer ecosystem -- Chapter 10: Metabolic regulation in cancer ecosystem -- Chapter 11: Vascular regulation in cancer ecosystem -- Chapter 12: Microbial interaction in cancer ecosystem -- Chapter 13: Viral interaction in cancer ecosystem -- Chapter 14: Evolution of cancer ecosystem -- Chapter 15: Driving force of cancer ecosystem -- Chapter 16: Modeling, visualizing and subtyping the cancer ecosystem -- Chapter 17: Bio-engineering methods to mimic cancer ecosystem -- Chapter 18: Cancer ecosystem-directed therapeutic strategies.
330   $aThis book intends to report new concept of onco-spheres in cancer ecosystem. Onco-spheres are defined as where cancer cells (living organisms) dynamically interact with nontumor cellular (other living organisms) and noncellular components (non-living environmental factors) in the ?host? internal environment (habitat) to construct a self-sustainable cancer ecosystem, which can be scoped at three different levels: primary/regional, distal and systemic onco-spheres. Cancer cells should be conceived as ?living organisms?, interacting with cellular or noncellular components in the host internal environment, not only with the local tumor microenvironment (TME) but also constantly communicating with a distant organ niche as well interacting with the host?s nervous, endocrine and immune systems, to construct a self-sustainable ?biosphere?, as we termed the tumor ecosystem. By looking at the interaction of cancer and host as a unique ecosystem, we will use ecology principles to further delineate the features of the dynamics of the tumor ecosystem. As the pioneer in proposing this concept, we feel that this full-scale overview of the tumor ecosystem is able to inform the readers about this concept, and to pave the way for designing novel therapeutic strategies on actionable targets within tumor ecosystem. The book is likely to be of interest to immunologist, biologist, medical students, researchers and general public who wish to learn more on this new concept of tumor ecosystem, and how this could be applied in many fields of research.
606   $aMedicine?Research
606   $aBiology?Research
606   $aCancer
606   $aTumors?Immunological aspects
606   $aBiomedical Research
606   $aCancer Biology
606   $aCancer Microenvironment
606   $aTumour Immunology
615  0$aMedicine?Research.
615  0$aBiology?Research.
615  0$aCancer.
615  0$aTumors?Immunological aspects.
615 14$aBiomedical Research.
615 24$aCancer Biology.
615 24$aCancer Microenvironment.
615 24$aTumour Immunology.
676   $a616.994
702   $aSong$b Erwei
801  0$bMiAaPQ
801  1$bMiAaPQ
801  2$bMiAaPQ
906   $aBOOK
912   $a9910735779203321
996   $aTumor Ecosystem$93417153
997   $aUNINA