LEADER 04724nam 22007575 450 001 9910735775703321 005 20251008131253.0 010 $a3-031-32554-0 024 7 $a10.1007/978-3-031-32554-0 035 $a(MiAaPQ)EBC30656997 035 $a(Au-PeEL)EBL30656997 035 $a(DE-He213)978-3-031-32554-0 035 $a(PPN)272250503 035 $a(CKB)27675012200041 035 $a(EXLCZ)9927675012200041 100 $a20230719d2023 u| 0 101 0 $aeng 135 $aurcnu|||||||| 181 $ctxt$2rdacontent 182 $cc$2rdamedia 183 $acr$2rdacarrier 200 10$aAdvances in Maternal-Fetal Biomedicine $eCellular and Molecular Mechanisms of Pregnancy Pathologies /$fedited by Marcelo Gonzalez-Ortiz 205 $a1st ed. 2023. 210 1$aCham :$cSpringer International Publishing :$cImprint: Springer,$d2023. 215 $a1 online resource (314 pages) 225 1 $aAdvances in Experimental Medicine and Biology,$x2214-8019 ;$v1428 311 08$aPrint version: Gonzalez-Ortiz, Marcelo Advances in Maternal-Fetal Biomedicine Cham : Springer International Publishing AG,c2023 9783031325533 320 $aIncludes bibliographical references and index. 327 $aFeto-Placental Unit: from development to function -- Role of hormones during gestation and early development: pathways involved in developmental programming -- Physiological and pathophysiological role of large-conductance calcium-activated potassium channels (BKCa) in HUVECs and placenta -- Metabolic interaction between Folate, Vitamin B12 and Polyunsaturated Fatty Acids in pregnancy -- Evidence of nitric oxide impairment during hypertensive pregnancies -- Pathophysiology of preeclampsia and L-Arginine/L-citrulline supplementation as a potential strategy to improve birth outcomes -- Maternal and fetal expression of ATP-binding cassette and Solute Carrier transporters involved in the brain disposition of drugs -- Development of the placenta and brain are affected by selective serotonin reuptake inhibitors exposure during critical periods -- The endocannabinoid system in placenta and respiratory central nervous system development: effects of prenatal exposure to cannabinoids -- Impact of prenatal nicotine exposure on placental function and respiratory neural network development -- Language impairment in children of mothers with gestational diabetes, preeclampsia, and preterm delivery: current hypothesis and potential underlying mechanisms -- COVID-19 on pregnancy outcomes, mental health and placenta: focus in Latin America -- The placental function beyond pregnancy: Insights from Latin America. 330 $aThis textbook aims to describe physiological and pathophysiological mechanisms that underlie human maternal-fetal interactions. The book emphasizes the structure and development of the fetoplacental unit, the endocrine and nutritional regulation of fetal development, nitric oxide signalling, solute carriers function and ion channels regulation in healthy pregnancies and diseases, like preeclampsia, gestational diabetes, and maternal obesity, among others. Also, we highlight novel mechanisms associated with language impairment in children, the use of serotonin inhibitors or cannabis during pregnancy, and maternal conditions' potential impact on cerebrovascular development in newborns and infants. The cellular and molecular understanding of maternal-fetal physiology and pathophysiology will allow the readers to understand the impact of diseases or conditions that are highly prevalent in pregnant women. 410 0$aAdvances in Experimental Medicine and Biology,$x2214-8019 ;$v1428 606 $aHuman physiology 606 $aReproductive health 606 $aReproduction 606 $aPhysiology 606 $aPharmacology 606 $aCytology 606 $aGynecology 606 $aHuman Physiology 606 $aReproductive Medicine 606 $aReproductive Physiology 606 $aPharmacology 606 $aCell Biology 606 $aGynecology 615 0$aHuman physiology. 615 0$aReproductive health. 615 0$aReproduction. 615 0$aPhysiology. 615 0$aPharmacology. 615 0$aCytology. 615 0$aGynecology. 615 14$aHuman Physiology. 615 24$aReproductive Medicine. 615 24$aReproductive Physiology. 615 24$aPharmacology. 615 24$aCell Biology. 615 24$aGynecology. 676 $a618.2 702 $aGonza?lez-Ortiz$b Marcelo 801 0$bMiAaPQ 801 1$bMiAaPQ 801 2$bMiAaPQ 906 $aBOOK 912 $a9910735775703321 996 $aAdvances in Maternal-Fetal Biomedicine$93417120 997 $aUNINA