LEADER 00723nam 2200229 450 001 9910734501303321 005 20230725133358.0 010 $a88-13-26203-5 100 $a20230725d2006----u y0engy50 ba 101 0 $aita 102 $aIT 105 0 $a 00 200 1 $a<> Nazioni unite viste da vicino$eAspetti e problemi dell'attività dell'ONU e dell'azione dell'Italia$fa cura di Stefano Baldi e Cinzia Buccianti 210 $aPadova$cCedam$d2006 225 $aUniversità degli studi di Siena 702 1$aBaldi$bStefano 702 $aBuccianti$bCinzia 912 $a9910734501303321 952 $aQ94(M)$bDSI 366/2023$fDSI 959 $aDSI 996 $aNazioni Unite viste da vicino$91204511 997 $aUNINA LEADER 04595nam 22008175 450 001 9910298295303321 005 20200704035825.0 010 $a3-319-12136-7 024 7 $a10.1007/978-3-319-12136-9 035 $a(CKB)3710000000311736 035 $a(EBL)1967973 035 $a(OCoLC)897810288 035 $a(SSID)ssj0001407851 035 $a(PQKBManifestationID)11933633 035 $a(PQKBTitleCode)TC0001407851 035 $a(PQKBWorkID)11411600 035 $a(PQKB)11630709 035 $a(DE-He213)978-3-319-12136-9 035 $a(MiAaPQ)EBC1967973 035 $a(PPN)183153316 035 $a(EXLCZ)993710000000311736 100 $a20141204d2015 u| 0 101 0 $aeng 135 $aur|n|---||||| 181 $ctxt 182 $cc 183 $acr 200 10$aGenomic Instability and Cancer Metastasis $eMechanisms, Emerging Themes, and Novel Therapeutic Strategies /$fedited by Chris Maxwell, Cal Roskelley 205 $a1st ed. 2015. 210 1$aCham :$cSpringer International Publishing :$cImprint: Springer,$d2015. 215 $a1 online resource (252 p.) 225 1 $aCancer Metastasis - Biology and Treatment,$x1568-2102 ;$v20 300 $aDescription based upon print version of record. 311 $a3-319-12135-9 320 $aIncludes bibliographical references and index. 327 $aPreface.- Cancer Metastasis: Tracking and Attacking a Moving Target.- The generation, detection, and prevention of genomic instability during cancer progression and metastasis.- DNA damage response pathways in cancer predisposition and progression.- Mathematical modeling for DNA repair, carcinogenesis and cancer detection.- Animal models of metastasis.- Microenvironmental Control Of Metastatic Progression.- 7 Mechanotransduction, metastasis and genomic instability -- 8 Immunomodulation and Genomic Instability -- 9 Synthetic Genetic Approaches in Colorectal Cancer: Exploiting and Targeting Genome Instability -- Nanomedicine ? Nanoparticles in Cancer Imaging and Therapy -- Index. 330 $aMetastasis is the primary cause of mortality associated with cancer, and tumor genomic heterogeneity is a likely source for the cells that support cancer progression, resistance to therapy, and disease relapse. This book connects cancer metastasis with genomic instability in a comprehensive manner. Section 1  outlines the fundamental mechanisms responsible for these cellular and tissue phenotypes. Section 2 discusses in silico, in vitro, and in vivo models used for the experimental study of these processes. Section 3 reviews emerging themes (ex., microenvironment, mechanotransduction, and immunomodulation), and Section 4 highlights new therapeutic approaches to overcome the unique challenges presented by the heterogeneous and metastatic tumor. This book is intended for undergraduates and postgraduates with an interest in the areas of medicine, oncology, and cancer biology as well as for the content expert searching for thorough reviews of current knowledge in these areas. 410 0$aCancer Metastasis - Biology and Treatment,$x1568-2102 ;$v20 606 $aCancer$xResearch 606 $aMedicine 606 $aMolecular biology 606 $aLife sciences 606 $aCytology 606 $aCancer Research$3https://scigraph.springernature.com/ontologies/product-market-codes/B11001 606 $aBiomedicine, general$3https://scigraph.springernature.com/ontologies/product-market-codes/B0000X 606 $aMolecular Medicine$3https://scigraph.springernature.com/ontologies/product-market-codes/B1700X 606 $aLife Sciences, general$3https://scigraph.springernature.com/ontologies/product-market-codes/L00004 606 $aCell Biology$3https://scigraph.springernature.com/ontologies/product-market-codes/L16008 615 0$aCancer$xResearch. 615 0$aMedicine. 615 0$aMolecular biology. 615 0$aLife sciences. 615 0$aCytology. 615 14$aCancer Research. 615 24$aBiomedicine, general. 615 24$aMolecular Medicine. 615 24$aLife Sciences, general. 615 24$aCell Biology. 676 $a570 676 $a571.6 676 $a610 676 $a611.01816 702 $aMaxwell$b Chris$4edt$4http://id.loc.gov/vocabulary/relators/edt 702 $aRoskelley$b Cal$4edt$4http://id.loc.gov/vocabulary/relators/edt 801 0$bMiAaPQ 801 1$bMiAaPQ 801 2$bMiAaPQ 906 $aBOOK 912 $a9910298295303321 996 $aGenomic Instability and Cancer Metastasis$92503140 997 $aUNINA