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181   $ctxt$2rdacontent
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200 10$aAntimalarial Natural Products /$fedited by A. Douglas Kinghorn, Heinz Falk, Simon Gibbons, Yoshinori Asakawa, Ji-Kai Liu, Verena M. Dirsch
205   $a1st ed. 2022.
210  1$aCham :$cSpringer International Publishing :$cImprint: Springer,$d2022.
215   $a1 online resource (115 pages)
225 1 $aProgress in the Chemistry of Organic Natural Products,$x2192-4309 ;$v117
311 08$aPrint version: Kinghorn, A. Douglas Antimalarial Natural Products Cham : Springer International Publishing AG,c2022 9783030898724 
330   $aThis volume begins with a short history of malaria and follows with a summary of its biology. It then traces the fascinating history of the discovery of quinine for malaria treatment, and then describes quinine?s biosynthesis, its mechanism of action, and its clinical use, concluding with a discussion of synthetic antimalarial agents based on quinine?s structure. It also covers the discovery of artemisinin and its development as the source of the most effective current antimalarial drug, including summaries of its synthesis and biosynthesis, its mechanism of action, and its clinical use and resistance. A short discussion of other clinically used antimalarial natural products leads to a detailed treatment of additional natural products with significant antiplasmodial activity, classified by compound type. Although the search for new antimalarial natural products from Nature?s combinatorial library is challenging, it is very likely to yield new antimalarial drugs. This book thus ends by identifying ten natural products with development potential as clinical antimalarial agents.
410  0$aProgress in the Chemistry of Organic Natural Products,$x2192-4309 ;$v117
606   $aNatural products
606   $aPharmaceutical chemistry
606   $aParasitology
606   $aChemistry, Organic
606   $aPharmaceutical chemistry
606   $aNatural Products
606   $aMedicinal Chemistry
606   $aParasitology
606   $aOrganic Chemistry
606   $aPharmaceutics
615  0$aNatural products.
615  0$aPharmaceutical chemistry.
615  0$aParasitology.
615  0$aChemistry, Organic.
615  0$aPharmaceutical chemistry.
615 14$aNatural Products.
615 24$aMedicinal Chemistry.
615 24$aParasitology.
615 24$aOrganic Chemistry.
615 24$aPharmaceutics.
676   $a572
702   $aKinghorn$b A. Douglas
801  0$bMiAaPQ
801  1$bMiAaPQ
801  2$bMiAaPQ
906   $aBOOK
912   $a9910733726203321
996   $aAntimalarial Natural Products$93393824
997   $aUNINA