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010   $a3-319-33172-8
024 7 $a10.1007/978-3-319-33172-0
035   $a(CKB)3710000000746200
035   $a(DE-He213)978-3-319-33172-0
035   $a(MiAaPQ)EBC4584992
035   $a(PPN)194512231
035   $a(EXLCZ)993710000000746200
100   $a20160705d2016      u|         0
101 0 $aeng
135   $aurnn|008mamaa
181   $ctxt$2rdacontent
182   $cc$2rdamedia
183   $acr$2rdacarrier
200 10$aProgress in the Chemistry of Organic Natural Products 102 /$fedited by A. Douglas Kinghorn, Heinz Falk, Simon Gibbons, Jun'ichi Kobayashi
205   $a1st ed. 2016.
210  1$aCham :$cSpringer International Publishing :$cImprint: Springer,$d2016.
215   $a1 online resource (V, 252 p. 190 illus., 10 illus. in color.) 
225 1 $aProgress in the Chemistry of Organic Natural Products,$x2192-4309 ;$v102
311   $a3-319-33170-1 
320   $aIncludes bibliographical references at the end of each chapters.
330   $aThe first contribution reviews the phytochemical, chemical, and biological literature on members of the ingenane class of diterpenoids from their first isolation in 1968 through 2015, highlighting unresolved issues both common to phorboids and specific to ingenol derivatives. The biogenesis of ingenol is discussed in the light of the Jakupovic proposal of a dissection between the formation of the macrocyclic Euphorbia diterpenoids and the phorboids, and the clinical development of ingenol mebutate is chronicled in the light of its ?reverse-pharmacology? focus. The second contribution offers a comprehensive view of the chemical wealth and the taxonomic problems currently impeding chemical and biological investigations of the genus Laurencia. It addresses the botanical description and the growth and population dynamics of the genus, as well as its chemical diversity and ecological relations; the secondary metabolites as well as their sources of isolation; and finally the biological activity.
410  0$aProgress in the Chemistry of Organic Natural Products,$x2192-4309 ;$v102
606   $aChemistry, Organic
606   $aMedicinal chemistry
606   $aClinical biochemistry
606   $aOrganic Chemistry
606   $aMedicinal Chemistry
606   $aMedical Biochemistry
615  0$aChemistry, Organic.
615  0$aMedicinal chemistry.
615  0$aClinical biochemistry.
615 14$aOrganic Chemistry.
615 24$aMedicinal Chemistry.
615 24$aMedical Biochemistry.
676   $a547
702   $aKinghorn$b A. Douglas$4edt$4http://id.loc.gov/vocabulary/relators/edt
702   $aFalk$b Heinz$4edt$4http://id.loc.gov/vocabulary/relators/edt
702   $aGibbons$b Simon$4edt$4http://id.loc.gov/vocabulary/relators/edt
702   $aKobayashi$b Jun'ichi$4edt$4http://id.loc.gov/vocabulary/relators/edt
906   $aBOOK
912   $a9910733717703321
996   $aProgress in the Chemistry of Organic Natural Products 102$92518732
997   $aUNINA