LEADER 06366nam 22007215 450 001 9910733716403321 005 20230613071901.0 010 $a3-319-22692-4 024 7 $a10.1007/978-3-319-22692-7 035 $a(CKB)3710000000532686 035 $a(EBL)4189314 035 $a(SSID)ssj0001597005 035 $a(PQKBManifestationID)16296508 035 $a(PQKBTitleCode)TC0001597005 035 $a(PQKBWorkID)14885864 035 $a(PQKB)11787068 035 $a(DE-He213)978-3-319-22692-7 035 $a(MiAaPQ)EBC4189314 035 $a(PPN)190883189 035 $a(EXLCZ)993710000000532686 100 $a20151211d2016 u| 0 101 0 $aeng 135 $aur|n|---||||| 181 $ctxt 182 $cc 183 $acr 200 10$aProgress in the Chemistry of Organic Natural Products 101 /$fedited by A. D. Kinghorn, Heinz Falk, Simon Gibbons, Jun'ichi Kobayashi 205 $a1st ed. 2016. 210 1$aCham :$cSpringer International Publishing :$cImprint: Springer,$d2016. 215 $a1 online resource (236 p.) 225 1 $aProgress in the Chemistry of Organic Natural Products,$x2192-4309 ;$v101 300 $a"2192-4309"--Title page verso. 311 $a3-319-22691-6 320 $aIncludes bibliographical references at the end of each chapters. 327 $aContents; Dimeric Sesquiterpenoids; 1 Introduction; 2 Classification and Distribution; 2.1 Disesquiterpenoid DSs; 2.1.1 Bisabolane Disesquiterpenoids; 2.1.2 Germacrane Disesquiterpenoids; 2.1.3 Guaiane, Pseudoguaiane, and Xanthane Disesquiterpenoids; 2.1.4 Eremophilane Disesquiterpenoids; 2.1.5 Cadinane Disesquiterpenoids; 2.1.6 Eudesmane Disesquiterpenoids; 2.1.7 Lindenane Disesquiterpenoids; 2.1.8 Cuparane, Cyclolaurane, and Herbertane Disesquiterpenoids; 2.1.9 Miscellaneous Disesquiterpenoids; 2.1.10 Compound Disesquiterpenoids; 2.2 Pseudo-disesquiterpenoids 327 $a2.2.1 Dimeric Aza-sesquiterpenoids2.2.2 Miscellaneous Pseudo-disesquiterpenoids; 3 Structural Elucidation; 3.1 General; 3.2 Mass Spectrometry; 3.3 Nuclear Magnetic Resonance Spectroscopy; 3.4 Single-Crystal X-Ray Diffraction; 3.5 CD and ECD Calculations; 3.6 Chemical Methods; 3.7 Structural Elucidation of Serratustone A; 4 Biological Activity; 4.1 Cytotoxic and Antitumor Activity; 4.2 Anti-inflammatory Activity; 4.3 Immunosuppressive Activity; 4.4 Potassium Channel Blocking and Cardiovascular Activity; 4.5 Antimalarial, Antiprotozoal, Antibacterial, Antifungal, and Antiviral Activity 327 $a4.6 Neurotrophic Activity4.7 Miscellaneous Activities; 5 Synthesis; 5.1 Biogenesis; 5.1.1 [4+2] Diels-Alder Reactions; 5.1.2 [2+2] Cycloaddition and [6+6] Cycloaddition; 5.1.3 Radical Reactions; 5.1.4 Aldol Reactions; 5.1.5 Esterification, Etherification, and Acetal-Formation Reactions; 5.1.6 Dimerization Through a Linker; 5.1.7 Michael-Type Reactions; 5.2 Chemical Synthesis; 5.2.1 Diels-Alder Cycloaddition; 5.2.2 Oxidative Coupling; 5.2.3 Dimerization with Linkers; 5.2.4 Miscellaneous Dimerization Methods; 6 Conclusions; References; Acetogenins from Annonaceae; 1 Introduction 327 $a2 Annonaceous Acetogenins in the Plant Kingdom3 Classification of Annonaceous Acetogenins (Since 1997 Until the End of 2014); 3.1 Linear and Epoxy Annonaceous Acetogenins; 3.2 Mono-THF Annonaceous Acetogenins, Including Derivatives with a Mono-THF Ring; 3.3 Bis-THF Annonaceous Acetogenins, Including Derivatives with Adjacent or Non-adjacent Bis-THF Rings; 3.4 Miscellaneous; 4 Chemotaxonomy of the Annonaceae Family; 5 Synthesis of Annonaceous Acetogenins; 5.1 Linear Annonaceous Acetogenins; 5.1.1 Montecristin; 5.1.2 (-)-Muricatacin; 5.1.3 Tonkinelin; 5.2 Mono-THF Annonaceous Acetogenins 327 $a5.3 Adjacent Bis-THF Annonaceous Acetogenins5.4 Non-adjacent Bis-THF Annonaceous Acetogenins; 5.5 Other AGEs; 5.5.1 Adjacent Type THF-THP AGEs; 5.5.2 Non-adjacent THF-THP Type; 5.5.3 THP Type; 5.5.4 Tri-THF Type; 5.5.5 Bis-lactone Type; 6 Biological Activity and Mechanism of Action of Annonaceous Acetogenins; 6.1 Pesticidal Activities; 6.2 Cytotoxic, Cancer-Related, and Ionophore Activities (Anticancer Activity); 6.3 Neurotoxic Activities; 6.4 Other Activities; 6.4.1 Anti-inflammatory Effects; 6.4.2 Promotion of Biofilm Formation in Microbes; 6.4.3 Interaction of AGEs with Membranes 327 $a6.4.4 AGEs as Cation Ionophores 330 $aThe volumes of this classic series, now referred to simply as "Zechmeister" after its founder, Laszlo Zechmeister, have appeared under the Springer Imprint ever since the series' inauguration in 1938. The series has featured contributions by seven Nobel laureates: D.H.R. Barton, D. Crowfoot Hodgkin, L. Pauling, K. Alder, O. Diels, P. Karrer, and H. von Euler-Chelpin. The volumes contain contributions on various topics related to the origin, distribution, chemistry, synthesis, biochemistry, function or use of various classes of naturally occurring substances ranging from small molecules to biopolymers. Each contribution is written by a recognized authority in the field and provides a comprehensive and up-to-date review of the topic in question. Addressed to biologists, technologists, and chemists alike, the series can be used by the expert as a source of information and literature citations and by the non-expert as a means of orientation in a rapidly developing discipline. 410 0$aProgress in the Chemistry of Organic Natural Products,$x2192-4309 ;$v101 606 $aChemistry, Organic 606 $aMedicinal chemistry 606 $aClinical biochemistry 606 $aOrganic Chemistry 606 $aMedicinal Chemistry 606 $aMedical Biochemistry 615 0$aChemistry, Organic. 615 0$aMedicinal chemistry. 615 0$aClinical biochemistry. 615 14$aOrganic Chemistry. 615 24$aMedicinal Chemistry. 615 24$aMedical Biochemistry. 676 $a540 702 $aKinghorn$b A. D$4edt$4http://id.loc.gov/vocabulary/relators/edt 702 $aFalk$b Heinz$4edt$4http://id.loc.gov/vocabulary/relators/edt 702 $aGibbons$b Simon$4edt$4http://id.loc.gov/vocabulary/relators/edt 702 $aKobayashi$b Jun'ichi$4edt$4http://id.loc.gov/vocabulary/relators/edt 906 $aBOOK 912 $a9910733716403321 996 $aProgress in the Chemistry of Organic Natural Products 101$92505865 997 $aUNINA