LEADER 03925oam 22004935 450 001 9910733715503321 005 20240117173511.0 010 $a3-031-10457-9 024 7 $a10.1007/978-3-031-10457-2 035 $a(MiAaPQ)EBC7167839 035 $a(Au-PeEL)EBL7167839 035 $a(CKB)25936431000041 035 $a(DE-He213)978-3-031-10457-2 035 $a(PPN)267808798 035 $a(EXLCZ)9925936431000041 100 $a20230101d2023 uy 0 101 0 $aeng 135 $aurcnu|||||||| 181 $ctxt$2rdacontent 182 $cc$2rdamedia 183 $acr$2rdacarrier 200 10$aAncistrocladus naphthylisoquinoline alkaloids /$fedited by A. Douglas Kinghorn, Heinz Falk, Simon Gibbons, Yoshinori Asakawa, Ji-Kai Liu, Verena M Dirsch 205 $a1st ed. 2023. 210 1$aCham :$cSpringer International Publishing :$cImprint: Springer,$d2023. 215 $a1 online resource (344 pages) $cillustrations (black and white, and colour) 225 1 $aProgress in the Chemistry of Organic Natural Products,$x2192-4309 ;$v119 311 08$aPrint version: Kinghorn, A. Douglas Ancistrocladus Naphthylisoquinoline Alkaloids Cham : Springer International Publishing AG,c2023 9783031104565 327 $a1. Introduction -- 2. Naphthylisoquinoline Alkaloids, a Fascinating Class of Axially Chiral Biaryl Natural Products -- 3. Ancistrocladus, a Genus of Woody Lianas of the Monotypic Plant Family Ancistrocladaceae Widely Occurring in India, Sri Lanka, and Southeast Asia -- 4.The Indian Liana Ancistrocladus heyneanus and Ancistrocladus hamatus from Sri Lanka: Early Studies and More Recent Discoveries -- Full Absolute Stereostructures of Naphthylisoquinoline Alkaloids Directly from Crude Extracts: Characterization of New Metabolites from Ancistrocladus griffithii by the HPLC-MS/MS-NMR-ECD Triad -- 6. Ancistrobenomine A, the First Naphthylisoquinoline Alkaloid with a Hydroxymethylene Function at C-3, and Related 5,1'-Coupled Compounds -- 7. Ancistrocladus cochinchinensis from Central Vietnam, a Distinct Ancistrocladus Taxon? ? Metabolite Pattern und Phylogenetic Relationship to Ancistrocladus aff. tectorius from China -- 8.Widespread Throughout Southeast Asia: Ancistrocladus tectorius, a Rich Source of Unique, Structurally Most Diverse Mono- and Dimeric Naphthylisoquinoline Alkaloids -- 9. Tables of the Naphthylisoquinoline Alkaloids and Related Compounds Isolated from Asian Ancistrocladus Species. 330 $aThis book describes a unique class of secondary metabolites, the mono- and dimeric-naphthylisoquinoline alkaloids. They exclusively occur in lianas of the palaeotropical Ancistrocladaceae and Dioncophyllaceae plant families. Their unprecedented structures include stereogenic centers and rotationally hindered, and therefore stereogenic, axes. Extended recent investigations on six Ancistrocladus species from Asia, as reported in this contribution, shed light on their fascinating phytochemical productivity, with over 100 intriguing natural products. This high chemodiversity arises from a similarly unique biosynthesis from acetate-malonate units, following a novel polyketidic pathway to plant-derived isoquinoline alkaloids. Some of the compounds show most promising anti-parasitic activities. Additionally, strategies for the regio- and stereoselective total synthesis of the alkaloids, including the directed construction of the chiral axis, are also presented. 410 0$aProgress in the Chemistry of Organic Natural Products,$x2192-4309 ;$v119 606 $aAlkaloids 606 $aBotanical chemistry 615 0$aAlkaloids. 615 0$aBotanical chemistry. 676 $a769 676 $a572.549 702 $aKinghorn$b A. Douglas 801 0$bMiAaPQ 801 1$bMiAaPQ 801 2$bMiAaPQ 906 $aBOOK 912 $a9910733715503321 996 $aAncistrocladus naphthylisoquinoline alkaloids$93398412 997 $aUNINA