LEADER 06509nam 22007215 450 001 9910733712203321 005 20251113173936.0 010 $a3-031-04039-2 024 7 $a10.1007/978-3-031-04039-9 035 $a(MiAaPQ)EBC7023495 035 $a(Au-PeEL)EBL7023495 035 $a(CKB)24094268100041 035 $a(OCoLC)1334106548 035 $a(DE-He213)978-3-031-04039-9 035 $a(EXLCZ)9924094268100041 100 $a20220627d2022 u| 0 101 0 $aeng 135 $aurcnu|||||||| 181 $ctxt$2rdacontent 182 $cc$2rdamedia 183 $acr$2rdacarrier 200 10$aMicrofluidics and Biosensors in Cancer Research $eApplications in Cancer Modeling and Theranostics /$fedited by David Caballero, Subhas C. Kundu, Rui L. Reis 205 $a1st ed. 2022. 210 1$aCham :$cSpringer International Publishing :$cImprint: Springer,$d2022. 215 $a1 online resource (598 pages) $cillustrations 225 1 $aAdvances in Experimental Medicine and Biology,$x2214-8019 ;$v1379 311 08$aPrint version: Caballero, David Microfluidics and Biosensors in Cancer Research Cham : Springer International Publishing AG,c2022 9783031040382 320 $aIncludes bibliographical references. 327 $aPart 1. Fundamentals of Microfluidics and Biosensors -- Chapter 1. Fundamentals of Biosensors and Detection Methods -- Chapter 2. How to Get Away with Gradients -- Chapter 3. Sensors and Biosensors in Organs-on-a-chip Platforms -- Chapter 4. Current Trends in Microfluidics and Biosensors for Cancer Research Applications -- Part 2. Modelling the Tumor Microenvironment and Its Dynamic Events -- Chapter 5. The Tumor Microenvironment ? an Introduction for the Development of Microfluidic Devices -- Chapter 6. Biomaterials for Mimicking and Modelling Tumor Micro-environment -- Chapter 7. Advancing Tumor Microenvironment Research by Combining Organs-on-chips and Biosensors -- Chapter 8. Microfluidic-driven Biofabrication and the Engineering of Cancer-like Microenvironments -- Chapter 9. Advances in 3d Vascularized Tumor-on-a-chip Technology -- Part 3. Cancer Detection and Diagnosis -- Chapter 10. Biosensors Advances: Contributions to Cancer Diagnostics and Treatment -- Chapter 11. Flexible Sensing Systemsfor Cancer Diagnostics -- Chapter 12. Coupling Micro-physiological Systems and Biosensors for Improving Cancer Biomarkers Detection -- Chapter 13. Microfluidic Biosensor-based Devices for Rapid Diagnosis and Effective Anti-cancer Therapeutic Monitoring for Breast Cancer Metastasis -- Chapter 14. Liquid Biopsies: Flowing Biomarkers -- Chapter 15. From Exosomes to Circulating Tumor Cells: Using Microfludics to Detect High Predictive Cancer Biomarkers -- Chapter 16. Microfluidics for the Isolation and Detection of Circulating Tumor Cells -- Chapter 17. Evolution in Automatized Detection of Cancer Cells: Advances in Magnetic Microcytometers -- Chapter 18. Droplet-based Microfluidic Chip Design, Fabrication and Use for Ultrahigh-throughput DNA Analysis and Quantification -- Chapter 19. Emerging Microfluidic and Biosensor Technologies for Improved Cancer Theranostics -- Part 4. Clinical Applications: Towards Personalized Medicine -- Chapter 20. Microfluidics for Cancer Biomarker Discovery, Research and Clinical Application -- Chapter 21. Methods for the Detection of Circulating Biomarkers in Cancer Patients -- Chapter 22. Advances in Microfluidics for the Implementation of Liquid Biopsy in Clinical Routine. 330 $aThis book offers a comprehensive overview of the development and application of microfluidics and biosensors in cancer research, in particular, their applications in cancer modeling and theranostics. Over the last decades, considerable effort has been made to develop new technologies to improve the diagnosis and treatment of cancer. Microfluidics has proven to be a powerful tool for manipulating biological fluids with high precision and efficiency and has already been adopted by the pharmaceutical and biotechnology industries. With recent technological advances, particularly biosensors, microfluidic devices have increased their usefulness and importance in oncology and cancer research. The aim of this book is to bring together in a single volume all the knowledge and expertise required for the development and application of microfluidic systems and biosensors in cancer modeling and theranostics. It begins with a detailed introduction to the fundamental aspects of tumor biology,cancer biomarkers, biosensors and microfluidics. With this knowledge in mind, the following sections highlight important advances in developing and applying biosensors and microfluidic devices in cancer research at universities and in the industry. Strategies for identifying and evaluating potent disease biomarkers and developing biosensors and microfluidic devices for their detection are discussed in detail. Finally, the transfer of these technologies into the clinical environment for the diagnosis and treatment of cancer patients will be highlighted. By combining the recent advances made in the development and application of microfluidics and biosensors in cancer research in academia and clinics, this book will be useful literature for readers from a variety of backgrounds. It offers new visions of how this technology can influence daily life in hospitals and companies, improving research methodologies and the prognosis of cancer patients. 410 0$aAdvances in Experimental Medicine and Biology,$x2214-8019 ;$v1379 606 $aCancer 606 $aBiochemical markers 606 $aMicrofluidics 606 $aPharmacology 606 $aCancer$xTreatment 606 $aCancer Biology 606 $aBiomarkers 606 $aMicrofluidics 606 $aPharmacology 606 $aCancer Therapy 615 0$aCancer. 615 0$aBiochemical markers. 615 0$aMicrofluidics. 615 0$aPharmacology. 615 0$aCancer$xTreatment. 615 14$aCancer Biology. 615 24$aBiomarkers. 615 24$aMicrofluidics. 615 24$aPharmacology. 615 24$aCancer Therapy. 676 $a610.28 676 $a616.99400285 702 $aCaballero$b David 702 $aKundu$b S. C$g(Subhas Chandra), 702 $aReis$b Rui L. 801 0$bMiAaPQ 801 1$bMiAaPQ 801 2$bMiAaPQ 906 $aBOOK 912 $a9910733712203321 996 $aMicrofluidics and biosensors in cancer research$93397893 997 $aUNINA