LEADER 03880nam 22006975 450 001 9910731488603321 005 20230610092500.0 010 $a3-031-32276-2 024 7 $a10.1007/978-3-031-32276-1 035 $a(MiAaPQ)EBC30591709 035 $a(Au-PeEL)EBL30591709 035 $a(DE-He213)978-3-031-32276-1 035 $a(PPN)272272930 035 $a(CKB)26895846200041 035 $a(EXLCZ)9926895846200041 100 $a20230610d2023 u| 0 101 0 $aeng 135 $aurcnu|||||||| 181 $ctxt$2rdacontent 182 $cc$2rdamedia 183 $acr$2rdacarrier 200 10$aSenescence Back and Forth /$fby Urs Nydegger, Thomas Lung 205 $a1st ed. 2023. 210 1$aCham :$cSpringer International Publishing :$cImprint: Springer,$d2023. 215 $a1 online resource (148 pages) 311 08$aPrint version: Nydegger, Urs Senescence Back and Forth Cham : Springer International Publishing AG,c2023 9783031322754 320 $aIncludes bibliographical references. 327 $aSenescence opposed to longevity -- Genetics, the language of Proteomics -- Plants Uncover Senescence Animals Way Off Humans -- Rejuvenation stops Senescence -- Overlap of Senescence with Disease -- Mosaic Restricted to the Individuum -- Remaining Time until Death -- Laboratory Checkups -- eroprotectors. 330 $aThis book is about lifelong ageing of humans. The basic biochemical and genetic mechanisms remain ill known, and differ among individuals. The book starts out to explore the plant and animal kingdoms to answer questions human ageing needs for understanding. First, we come to scrutinize time running out and what ?normal? means with impacts on the genome and on protein half- lives and function. Ageing goes beyond biochemical skid treated by geroprotector drugs, including biosimilars; albeit early diagnosis with standard medical laboratory assays, here addressed, sheds light with focus on basic research. Modern tools, including machine learning, and DNA technology, e.g. genomics, have already provided for unanticipated insights. The chapters then turn around senescence of the entire organism based on variable ageing of single organs embedded in neuronal networks . Psychological stress factors, dementia opposed to vigilance, and distinction of ageing from overt disease are contrasting in humans and are opposed in the book. Senescence, seen as a one way track may be reverted into rejuvenation, made possible by insights into immunosenescence and genomic approaches. Risk management in health insurance finds important clues in this book. The topics addressed between the book covers help to understand the trend to the ever- prolonging life expectancy beyond the centenarian age group; nursing care takers and pharmaceutical industry are invited to understand what? is going on in senior people to make their geriatric population remain fit or become frail. 606 $aAging 606 $aMedicine?Research 606 $aBiology?Research 606 $aPublic health 606 $aBiotechnology 606 $aPsychiatry 606 $aAgeing 606 $aBiomedical Research 606 $aPublic Health 606 $aChemical Bioengineering 606 $aPsychiatry 615 0$aAging. 615 0$aMedicine?Research. 615 0$aBiology?Research. 615 0$aPublic health. 615 0$aBiotechnology. 615 0$aPsychiatry. 615 14$aAgeing. 615 24$aBiomedical Research. 615 24$aPublic Health. 615 24$aChemical Bioengineering. 615 24$aPsychiatry. 676 $a612.67 700 $aNydegger$b Urs$01368679 702 $aLung$b Thomas 801 0$bMiAaPQ 801 1$bMiAaPQ 801 2$bMiAaPQ 906 $aBOOK 912 $a9910731488603321 996 $aSenescence Back and Forth$93394562 997 $aUNINA