LEADER 02519nam 2200361 450 001 9910729795003321 005 20230729162315.0 035 $a(CKB)4960000000468894 035 $a(NjHacI)994960000000468894 035 $a(EXLCZ)994960000000468894 100 $a20230729d2023 uy 0 101 0 $aeng 135 $aur||||||||||| 181 $ctxt$2rdacontent 182 $cc$2rdamedia 183 $acr$2rdacarrier 200 10$aTranscriptional Regulation and Its Misregulation in Human Diseases /$fAmelia Casamassimi, Alfredo Ciccodicola, Monica Rienzo 210 1$aBasel :$cMDPI - Multidisciplinary Digital Publishing Institute,$d2023. 215 $a1 online resource (308 pages) 311 $a3-0365-7736-X 330 $aTranscriptional regulation is a critical biological process that allows the cell or an organism to respond to a variety of intra- and extracellular signals, to define cell identity during development, to maintain it throughout its lifetime, and to coordinate cellular activity. This control involves multiple temporal and functional steps as well as innumerable molecules including transcription factors, cofactors, and chromatin regulators. It is well known that many human disorders are characterized by global transcriptional dysregulation because most of the signaling pathways ultimately target transcription machinery. Indeed, many syndromes and genetic and complex diseases--cancer, autoimmunity, neurological and developmental disorders, and metabolic and cardiovascular diseases--can be caused by mutations/alterations in regulatory sequences, transcription factors, splicing regulators, cofactors, chromatin regulators, ncRNAs, and other components of transcription apparatus. It is worth noting that advances in our understanding of molecules and mechanisms involved in the transcriptional circuitry and apparatus lead to new insights into the pathogenetic mechanisms of various human diseases and disorders. Thus, this Special Issue is focused on molecular genetics and genomics studies exploring the effects of transcriptional misregulation on human diseases. 606 $aGenetic regulation 615 0$aGenetic regulation. 676 $a572.865 700 $aCasamassimi$b Amelia$01376646 702 $aCiccodicola$b Alfredo 702 $aRienzo$b Monica 801 0$bNjHacI 801 1$bNjHacl 906 $aBOOK 912 $a9910729795003321 996 $aTranscriptional Regulation and Its Misregulation in Human Diseases$93412608 997 $aUNINA