LEADER 02319nam 2200397 450 001 9910727285203321 005 20240215192444.0 010 $a1-83768-239-9 024 7 $a10.5772/intechopen.104352 035 $a(CKB)5680000000309819 035 $a(NjHacI)995680000000309819 035 $a(EXLCZ)995680000000309819 100 $a20240215d2023 uy 0 101 0 $aeng 135 $aur||||||||||| 181 $ctxt$2rdacontent 182 $cc$2rdamedia 183 $acr$2rdacarrier 200 00$aMetformin $ea prospective alternative for the treatment of chronic diseases /$fedited by Farid A. Badria 210 1$aLondon :$cIntechOpen,$d2023. 215 $a1 online resource (102 pages) 311 $a1-83768-238-0 327 $a1. Metformin: A Small Molecule with Multi-Targets and Diverse Therapeutic Applications -- 2. Pharmacogenetics of Metformin in Type 2 Diabetes: Perspectives for Latin America -- 3. Therapeutic Potential of Metformin in Diabetes Mellitus-Related Cardiovascular Complications -- 4. Glycemic and Extraglycemic Effects of Metformin in Patients with Diabetes -- 5. Metformin in Non-Diabetic Conditions: An Overview. -- --. 330 $aCurrently, there are many complicated health disorders with different etiologies and pathogeneses, including cancers, obesity, periodontitis, cardiovascular disease, liver, skin and renal disorders. It is now known that the causes and pathogenesis of many complex chronic diseases are usually polyfactorial: genetic, environmental, constitutive factors, or a combination of these. Recently, poly-target molecules containing enzymes capable of catalyzing several reactions have been efficiently used in the treatment of several metabolic disorders, and infectious and inflammatory diseases. This book describes the history of the discovery of metformin and its chemistry. Topics presented include new approaches to the role of metformin in the treatment of diabetic patients and its ability to target multiple signaling pathways. 606 $aPharmacology 606 $aMetformin 615 0$aPharmacology. 615 0$aMetformin. 676 $a615.1 702 $aBadria$b Farid A. 801 0$bNjHacI 801 1$bNjHacl 906 $aBOOK 912 $a9910727285203321 996 $aMetformin$91952071 997 $aUNINA LEADER 07143nam 22008535 450 001 9910299256703321 005 20251226203218.0 010 $a3-319-25249-6 024 7 $a10.1007/978-3-319-25249-0 035 $a(CKB)3710000000521549 035 $a(SSID)ssj0001584324 035 $a(PQKBManifestationID)16262893 035 $a(PQKBTitleCode)TC0001584324 035 $a(PQKBWorkID)14865222 035 $a(PQKB)10799059 035 $a(DE-He213)978-3-319-25249-0 035 $a(MiAaPQ)EBC5594619 035 $a(MiAaPQ)EBC6303947 035 $a(Au-PeEL)EBL5594619 035 $a(OCoLC)932002756 035 $a(Au-PeEL)EBL6303947 035 $a(PPN)190535229 035 $a(EXLCZ)993710000000521549 100 $a20151007d2015 u| 0 101 0 $aeng 135 $aurnn|008mamaa 181 $ctxt 182 $cc 183 $acr 200 10$aSports Science Research and Technology Support $eSecond International Congress, icSPORTS 2014, Rome, Italy, October 24-26, 2014, Revised Selected Papers /$fedited by Jan Cabri, Joćo Barreiros, Pedro Pezarat Correia 205 $a1st ed. 2015. 210 1$aCham :$cSpringer International Publishing :$cImprint: Springer,$d2015. 215 $a1 online resource (XI, 119 p. 70 illus. in color.) 225 1 $aCommunications in Computer and Information Science,$x1865-0937 ;$v556 300 $aBibliographic Level Mode of Issuance: Monograph 311 08$a3-319-25248-8 327 $aIntro -- Preface -- Organization -- Contents -- Development of Skill Scoring System for Ski and Snowboard -- 1 Introduction -- 2 Backgrounds and Definitions -- 2.1 Training Methods Using Advanced Devices in Sports -- 2.2 Training Methods and Qualification for Skiing -- 2.3 Discussion -- 3 Ski Trainer System -- 3.1 Methods for Scoring -- 3.2 Implementation -- 4 Evaluation -- 4.1 Applying Ski Trainer to Snowboard -- 5 Conclusions -- References -- Monocular Tracking of Human Motion in Evaluation of Hurdle Clearance -- 1 Introduction -- 2 Articulated Human Motion Tracking -- 2.1 3D Human Body Model -- 2.2 Tracking Algorithm -- 2.3 Fitness Function -- 2.4 Data Collection -- 3 Experimental Results -- 4 Conclusions -- References -- Prediction of the Results in 400-Metres Hurdles in Two Different Time Intervals Using Statistical Learning Methods -- 1 Introduction -- 2 Materials and Methods -- 2.1 Regression Shrinkage Methods -- 2.2 Artificial Neural Networks -- 2.3 Evaluation of Models -- 3 Result and Discussion -- 3.1 Prediction in Training Periods -- 3.2 Prediction in Annual Training Cycle -- 4 Conclusions -- References -- Sampling Rates and Sensor Requirements for Kinematic Assessment During Running Using Foot Mounted IMUs -- 1 Introduction -- 2 Background -- 3 Sensor Platform and Data Capture -- 3.1 Inertial Sensors -- 3.2 Ground Truth -- 3.3 Combining Accelerometer Signals -- 4 Methods and Results -- 4.1 Effect of Sampling Rates -- 4.2 Sensor Requirements -- 4.3 Effect of Saturation on Measurement Accuracy -- 5 Conclusions -- References -- A Real-Time Simulator of Foiling Catamarans -- Abstract -- 1 Introduction -- 2 The Simulator -- 3 Mathematical Modeling -- 3.1 Geometric Characteristics -- 3.2 Appendages and Wing Sail -- 3.3 Reference Systems -- 3.4 Dynamic Equilibrium Equations -- 3.5 Forces and Moments -- 3.6 Cues to the User -- 4 Results. 327 $a4.1 Switching from Normal Floating Configuration to ``Flying'' Configuration -- 4.2 Total Resistance -- 4.3 Bear Away -- 4.4 Luff up -- 5 Graphical Interface -- 6 Conclusions and Further Work -- Acknowledgements -- References -- Guiding System for Visually Impaired Running on a Track -- 1 Introduction -- 2 Blindtrack Overview -- 2.1 System Description -- 2.2 Project Organization -- 3 Adapted Locating System -- 3.1 Basics of AoA -- 3.2 Basics of RTT -- 3.3 Infrastructure Setup -- 4 Evaluation -- 4.1 Measurement Campaign -- 4.2 Analysis -- 5 Summary & Roadmap -- References -- Hydrodynamic Resistance Prediction of an Olympic Class Sailing Dinghy Using CFD and Towing Tank Testing -- 1 Introduction -- 1.1 Background -- 1.2 Mechanisms of Sailing -- 1.3 Methodology -- 1.4 Towing Tank Test Setup -- 2 Computational Method -- 2.1 Governining Equations -- 2.2 Modelling Turbulence -- 2.3 The Volume of Fluid Method (VOF) -- 2.4 Numerical Representation -- 3 Verification Method -- 3.1 Richardson Extrapolation -- 3.2 The LSR Method -- 3.3 Uncertainty -- 4 Systematic Variation of Numerical Parameters -- 4.1 Numerical Parameter Study -- 4.2 Result of the Verification Study -- 5 Validation Results and Discussion -- 5.1 Heel Variation -- 5.2 Trim Variation -- 6 Concluding Remarks -- 6.1 Systematic Variation of Numerical Parameters -- 6.2 Main Investigation -- References -- Do We Need Goal Line Technology in Soccer or Could Video Proof Be a More Suitable Choice: A Cost-Benefit-Analysis of Goal Line Technology in Soccer and Thoughts About an Introduction of Video Proof -- Abstract -- 1 Introduction -- 2 Methods -- 2.1 Database -- 2.2 Operationalization -- 2.3 Video Replay -- 2.4 Reliability -- 3 Results -- 3.1 Critical Goal Line Decisions -- 3.2 Critical Goal Decisions -- 4 Discussion -- 4.1 Prevalence of Critical Goal Line Decisions and Other Critical Goal Calls. 327 $a4.2 Rate of Enlightenment -- 4.3 Obstacles and Pre-considerations for the Introduction of Video-Replay -- 5 Conclusion -- References -- Author Index. 330 $aThis book constitutes thoroughly revised and selected papers from the Second International Congress on Sports Science Research and Technology Support, icSPORTS 2014, held in Rome, Italy, in October 2014. The 8 thoroughly revised and extended papers presented in this volume were carefully reviewed and selected from originally 131 submissions. . 410 0$aCommunications in Computer and Information Science,$x1865-0937 ;$v556 606 $aMedical informatics 606 $aImage processing$xDigital techniques 606 $aComputer vision 606 $aComputer networks 606 $aApplication software 606 $aSports medicine 606 $aHealth Informatics 606 $aComputer Imaging, Vision, Pattern Recognition and Graphics 606 $aComputer Communication Networks 606 $aComputer and Information Systems Applications 606 $aSports Medicine 615 0$aMedical informatics. 615 0$aImage processing$xDigital techniques. 615 0$aComputer vision. 615 0$aComputer networks. 615 0$aApplication software. 615 0$aSports medicine. 615 14$aHealth Informatics. 615 24$aComputer Imaging, Vision, Pattern Recognition and Graphics. 615 24$aComputer Communication Networks. 615 24$aComputer and Information Systems Applications. 615 24$aSports Medicine. 676 $a613.71 702 $aCabri$b Jan 702 $aBarreiros$b Joa?o 702 $aPezarat-Correia$b Pedro$f1958- 801 0$bMiAaPQ 801 1$bMiAaPQ 801 2$bMiAaPQ 906 $aBOOK 912 $a9910299256703321 996 $aSports Science Research and Technology Support$92256429 997 $aUNINA