LEADER 04689nam 2200421z- 450 001 9910346749903321 005 20210212 035 $a(CKB)4920000000094215 035 $a(oapen)https://directory.doabooks.org/handle/20.500.12854/61459 035 $a(oapen)doab61459 035 $a(EXLCZ)994920000000094215 100 $a20202102d2018 |y 0 101 0 $aeng 135 $aurmn|---annan 181 $ctxt$2rdacontent 182 $cc$2rdamedia 183 $acr$2rdacarrier 200 00$aUbiquitin and Ubiquitin-Relative SUMO in DNA Damage Response 210 $cFrontiers Media SA$d2018 215 $a1 online resource (183 p.) 225 1 $aFrontiers Research Topics 311 08$a2-88945-441-X 330 $aDNA damage response (DDR) is a term that includes a variety of highly sophisticated mechanisms that cells have evolved in safeguarding the genome from the deleterious consequences of DNA damage. It is estimated that every single cell receives tens of thousands of DNA lesions per day. Failure of DDR to properly respond to DNA damage leads to stem cell dysfunction, accelerated ageing, various degenerative diseases or cancer. The sole function of DDR is to recognize diverse DNA lesions, signal their presence, activate cell cycle arrest and finally recruit specific DNA repair proteins to fix the DNA damage and thus prevent genomic instability. DDR is composed of hundreds of spatiotemporally regulated and interconnected proteins, which are able to promptly respond to various DNA lesions. So it is not surprising that mutations in genes encoding various DDR proteins cause embryonic lethality, malignancies, neurodegenerative diseases and premature ageing. The importance of DDR for cell survival and genome stability is unquestionable, but how the sophisticated network of hundreds of different DDR proteins is spatiotemporally coordinated is far from being understood. In the last ten years ubiquitin (ubiquitination) and the ubiquitin-relative SUMO (sumoylation) have emerged as essential posttranslational modifications that regulate DDR. Beside a plethora of ubiqutin and sumo E1-activating enzymes, E2-conjugating enzymes, E3-ligases and ubiquitin/sumo proteases involved in ubiquitination and sumoylation, the complexity of ubiqutin and sumo systems is additionally increased by the fact that both ubiquitin and sumo can form a variety of different chains on substrates which govern the substrate fate, such as its interaction with other proteins, changing its enzymatic activity or promoting substrate degradation. The importance of ubiquitin/SUMO systems in the orchestration of DDR is best illustrated in patients with mutations in E3-ubiquitin ligases BRCA1 or RNF168. BRCA1 is essential for proper function of DDR and its mutations lead to triple-negative breast and ovarian cancers. RNF168 is an E3 ubiquitin ligase, which creates the ubiquitin docking platform for recruitment of different DNA damage signalling and repair proteins at sites of DNA lesion, and its mutations cause RIDDLE syndrome characterized by radiosensitivity, immunodeficiency and learning disability. In addition, recently discovered the ubiquitin receptor protein SPRTN is part of the DNA replication machinery and its mutations cause early-onset hepatocellular carcinoma and premature ageing in humans. Despite more than 700 different enzymes directly involved in ubiquitination and sumoylation processes only few of them are known to play a role in DDR. Therefore, we feel that the role of ubiquitin and the ubiquitin-related SUMO in DDR is far from being understood, and that this is the emerging field that will hugely expand in the next decade due to the rapid development of a new generation of technologies, which will allow us a more robust and precise analyses of human genome, transcriptome and proteome. In this Research Topic we provide a comprehensive overview of our current understanding of ubiquitin and SUMO pathways in all aspects of DDR, from DNA replication to different DNA repair pathways, and demonstrate how alterations in these pathways cause genomic instability that is linked to degenerative diseases, cancer and pathological ageing. 606 $aGenetics (non-medical)$2bicssc 610 $aCancer 610 $aDNA damage response 610 $agenome stability 610 $aSUMO 610 $aSumoylation 610 $aUbiquitin 610 $aUbiquitination 615 7$aGenetics (non-medical) 700 $aKristijan Ramadan$4auth$01331087 702 $aIvan Dikic$4auth 906 $aBOOK 912 $a9910346749903321 996 $aUbiquitin and Ubiquitin-Relative SUMO in DNA Damage Response$93040115 997 $aUNINA LEADER 05289nam 22007575 450 001 9910725081403321 005 20251009080536.0 010 $a9783031301292$b(electronic bk.) 010 $z9783031301285 024 7 $a10.1007/978-3-031-30129-2 035 $a(PPN)283870443 035 $a(MiAaPQ)EBC30545020 035 $a(Au-PeEL)EBL30545020 035 $a(OCoLC)1379855221 035 $a(DE-He213)978-3-031-30129-2 035 $a(BIP)089230836 035 $a(CKB)26707047100041 035 $a(EXLCZ)9926707047100041 100 $a20230516d2023 u| 0 101 0 $aeng 135 $aurcnu|||||||| 181 $ctxt$2rdacontent 182 $cc$2rdamedia 183 $acr$2rdacarrier 200 10$aMaking Politics in Zimbabwe?s Second Republic $eThe Formative Project by Emmerson Mnangagwa /$fedited by Gorden Moyo, Kirk Helliker 205 $a1st ed. 2023. 210 1$aCham :$cSpringer Nature Switzerland :$cImprint: Springer,$d2023. 215 $a1 online resource (271 pages) 225 1 $aAdvances in African Economic, Social and Political Development,$x2198-7270 311 08$aPrint version: Moyo, Gorden Making Politics in Zimbabwe's Second Republic Cham : Springer,c2023 9783031301285 327 $aChapter 1: Mnangagwa?s Formative Project: Risks and Limits -- Part I: Activating Civil and Political Liberties -- Chapter 2: The Quest for Transitional Justice in the Post-Mugabe Era -- Chapter 3: Mnangagwa?s Missed Opportunities for Reconciliation -- Chapter 4: The Second Republic?s Stance on Corruption and the Battle for Public Confidence -- Chapter 5: Media Policies and Practices in Zimbabwe?s ?New Dispensation? -- Part II: Reconfiguring Governance -- Chapter 6: Exploring the Politics of Jecharism in Zimbabwe?s Second Republic -- Chapter 7: Change and Continuity: Traditional Leadership?s Political and Developmental Footprints in Zimbabwe?s Second Republic -- Chapter 8: Devolution in Zimbabwe?s ?Second Republic?: A Myth or Reality? -- Chapter 9: Prospects of Implementing Devolution in the Post-Mugabe Era -- Part III: Stimulating Socio-Economic Development -- Chapter 10: The Right to Development in Zimbabwe?s Second Republic -- Chapter 11: China?s Expanding Footprint and Deepening Debt Crisis in Zimbabwe ?From Robert Mugabe to Emmerson Mnangagwa -- Chapter 12: Financing the Social Sector in Zimbabwe?s Post-Mugabe Era ? Obstacles and Opportunities -- Chapter 13: Exploring Innovative and Sustainable Financing of Agriculture in Zimbabwe?s Second Republic -- Chapter 14: Concluding Reflections on Change and Continuity. 330 $aThe book provides a fresh and innovative interpretation of the new government of Zimbabwe led by Emmerson Mnangagwa, which emerged in late 2017 after the downfall of Robert Mugabe. It demonstrates the contradictory character of the Mnangagwa government, involving both continuities and discontinuities in relation to Mugabe?s regime . The temptation amongst Zimbabwean scholars has been to focus on the continuities and to dismiss the significance of any discontinuities, notably reform measures. This book adopts an alternative approach by identifying and focusing specifically on the existence of a formative project of the Mnangagwa?s Second Republic, further analysing its political significance, as well as risks and limitations. While doing so, the book covers topics such as reform measures, reconciliation, transitional justice, corruption, the media, agriculture, devolution, and the debt crisis as well as health and education. Discussing the limitations of these different reform measures, the book highlights that any scholarly failure to identify the risks of the project leads to an incomplete understanding of what constitutes the Mnangagwa?s Second Republic. The book appeals to students, scholars and researchers of Zimbabwean and African studies, political science and international relations, as well as policymakers interested in a better understanding of political reform processes. 410 0$aAdvances in African Economic, Social and Political Development,$x2198-7270 606 $aAfrica$xPolitics and government 606 $aElections 606 $aEconomic development 606 $aComparative government 606 $aPolitical science 606 $aPolitical leadership 606 $aAfrican Politics 606 $aElectoral Politics 606 $aDevelopment Studies 606 $aComparative Politics 606 $aPolitical Theory 606 $aPolitical Leadership 615 0$aAfrica$xPolitics and government. 615 0$aElections. 615 0$aEconomic development. 615 0$aComparative government. 615 0$aPolitical science. 615 0$aPolitical leadership. 615 14$aAfrican Politics. 615 24$aElectoral Politics. 615 24$aDevelopment Studies. 615 24$aComparative Politics. 615 24$aPolitical Theory. 615 24$aPolitical Leadership. 676 $a320.96891 700 $aMoyo$b Gorden$0853514 701 $aHelliker$b Kirk$01081669 801 0$bMiAaPQ 801 1$bMiAaPQ 801 2$bMiAaPQ 912 $a9910725081403321 996 $aMaking Politics in Zimbabwe's Second Republic$93367457 997 $aUNINA