LEADER 03452nam 2200541 450 001 9910720075603321 005 20230801215519.0 010 $a9783031315237$b(electronic bk.) 010 $z9783031315220 024 7 $a10.1007/978-3-031-31523-7 035 $a(MiAaPQ)EBC7241956 035 $a(Au-PeEL)EBL7241956 035 $a(OCoLC)1377819984 035 $a(DE-He213)978-3-031-31523-7 035 $a(PPN)269655778 035 $a(EXLCZ)9926523002200041 100 $a20230801d2023 uy 0 101 0 $aeng 135 $aurcnu|||||||| 181 $ctxt$2rdacontent 182 $cc$2rdamedia 183 $acr$2rdacarrier 200 00$aEndolysosomal voltage-dependent cation channels /$fedited by Christian Wahl-Schott and Martin Biel 205 $a1st ed. 2023. 210 1$aCham, Switzerland :$cSpringer Nature Switzerland AG,$d[2023] 210 4$dİ2023 215 $a1 online resource (310 pages) 225 1 $aHandbook of Experimental Pharmacology,$x1865-0325 ;$v278 311 08$aPrint version: Wahl-Schott, Christian Endolysosomal Voltage-Dependent Cation Channels Cham : Springer International Publishing AG,c2023 9783031315220 320 $aIncludes bibliographical references. 327 $aPart I: Physiological Functions of Endo-lysosomal Cation Channels -- NAADP-Mediated Ca2+ Signalling -- NAADP-Dependent TPC Current -- NAADP-Evoked Ca2+ Signaling: The DUOX2?HN1L/JPT2?Ryanodine Receptor 1 Axis -- TPC Functions in the Immune System -- Lysosomal Ion Channels and Lysosome? 1 Organelle Interactions -- TRPML1 and TFEB, an Intimate Affair -- Lysosomal Potassium Channels -- Part II Structure and Composition of TPC and TRPML Channels -- Structure and Function of Plant and Mammalian TPC Channels -- A Structural Overview of TRPML1 and the TRPML Family -- Endo-Lysosomal Two-Pore Channels and Their Protein Partners -- Part III: Tools and Methods to Characterize Endolysosomal Cation Channels -- Electrophysiological Techniques on the Study of Endolysosomal Ion Channels -- The Plant Vacuole as Heterologous System to Characterize the Functional Properties of TPC Channels -- Expanding the Toolbox: Novel Modulators of Endolysosomal Cation Channels -- Characterization of Endo-Lysosomal Cation Channels Using Calcium Imaging. 330 $aThis book covers the molecular structures and the cellular and in vivo function of endosomes and lysosomes, i.e. intracellular vesicles which are involved in many cellular processes such as endocytosis, intracellular trafficking, degradation of material from inside (e.g. autophagy) and outside the cell as well as exocytosis. Membranes of endolysosomal organelles contain an amazing number and diversity of ion channels. These ion channels are the topic of the present book that focusses on describing the structure, the biophysical properties, physiological functions of endolysosomal ion channels at the molecular, cellular and in vivo level. . 410 0$aHandbook of Experimental Pharmacology,$x1865-0325 ;$v278 606 $aEndosomes 606 $aIon channels 606 $aLysosomes 615 0$aEndosomes. 615 0$aIon channels. 615 0$aLysosomes. 676 $a571.64 702 $aWahl-Schott$b Christian 702 $aBiel$b Martin 801 0$bMiAaPQ 801 1$bMiAaPQ 801 2$bMiAaPQ 912 $a9910720075603321 996 $aEndolysosomal Voltage-Dependent Cation Channels$93359843 997 $aUNINA