LEADER 03585nam 2200505 450 001 9910720074003321 005 20230801215556.0 010 $a9789819910984$b(electronic bk.) 010 $z9789819910977 024 7 $a10.1007/978-981-99-1098-4 035 $a(MiAaPQ)EBC7242943 035 $a(Au-PeEL)EBL7242943 035 $a(DE-He213)978-981-99-1098-4 035 $a(OCoLC)1378079228 035 $a(PPN)269656774 035 $a(EXLCZ)9926540735100041 100 $a20230801d2023 uy 0 101 0 $aeng 135 $aurcnu|||||||| 181 $ctxt$2rdacontent 182 $cc$2rdamedia 183 $acr$2rdacarrier 200 10$aCopper(I)-catalyzed stereoselective borylation reactions $emultisubstituted alkenyl and allylic boronates /$fYu Ozawa 205 $a1st ed. 2023. 210 1$aSingapore :$cSpringer,$d[2023] 210 4$dİ2023 215 $a1 online resource (236 pages) 225 1 $aSpringer Theses, Recognizing Outstanding Ph.D. Research,$x2190-5061 311 08$aPrint version: Ozawa, Yu Copper(I)-Catalyzed Stereoselective Borylation Reactions Singapore : Springer,c2023 9789819910977 320 $aIncludes bibliographical references. 327 $a1. General Introduction -- 2. Modification of QuinoxP*-Type Bisphosphine Ligands for High-Performance Asymmetric Boryl Substitution of Racemic Allyl Electrophiles -- 3. Allylcopper(I) Isomerization-Enabled Copper(I)-Catalyzed Intramolecular Alkylboration of Terminal Allenes -- 4. Intermolecular Alkylboration of gem-Disubstituted Allenes for Stereoselective Synthesis of Multi-Alkylated Allylic Boronates -- 5. Computational Investigation on Copper(I)-Catalyzed Enantioselective Radical Borylation of Benzyl Halides -- 6. Summary of This Thesis. 330 $aThis book focuses on the development of novel functionalized organoboron compounds and those synthetic methods. High degrees of chemo-, regio-, and stereoselectivities of the borylation reactions are attained through catalyst design and optimization. Furthermore, the selectivity-determining mechanisms are analyzed with state-of-the-art DFT and other computational methods. In this book, the author synthesizes some multi-substituted alkenyl and allylic boronates via borylation reactions using a copper(I)/diboron catalyst system. Those compounds contain novel densely substituted and distorted structures, which have not been accessed by other methods. The high stereoselectivities are achieved by the optimization of the catalyst, especially the ligand. Some new ligands are also developed in this book. Furthermore, the derivatization of the borylation products is demonstrated to access the sterically demanding complex molecules. Also, the author performs computational analysis to reveal how the catalyst controls the selectivities. The deep insight into the reaction mechanism provides guides for rational catalyst design for not only copper(I) catalysis but also other transition metal catalysis. Thus, the content should be of interest to academic and industrial scientists in a wide range of areas. . 410 0$aSpringer Theses, Recognizing Outstanding Ph.D. Research,$x2190-5061 606 $aCopper catalysts 606 $aOrganoboron compounds$xSynthesis 615 0$aCopper catalysts. 615 0$aOrganoboron compounds$xSynthesis. 676 $a546.652595 700 $aOzawa$b Yu$01355734 801 0$bMiAaPQ 801 1$bMiAaPQ 801 2$bMiAaPQ 912 $a9910720074003321 996 $aCopper(I)-Catalyzed Stereoselective Borylation Reactions$93359829 997 $aUNINA