LEADER 04923nam 2200505 450 001 9910717369603321 005 20221026080207.0 035 $a(CKB)2670000000429649 035 $a(NjHacI)992670000000429649 035 $a(OCoLC)851144926$z(OCoLC)1117833222 035 $a(EXLCZ)992670000000429649 100 $a20221026d2012 uy 0 101 0 $aeng 135 $aur||||||||||| 181 $ctxt$2rdacontent 182 $cc$2rdamedia 183 $acr$2rdacarrier 200 10$aAdvanced wound care therapies for non-healing diabetic, venous, and arterial ulcers $ea systematic review /$fNancy Greer [and six others] 210 1$aWashington, District of Columbia :$cDepartment of Veterans Affairs (US),$d[2012] 210 4$dİ2012 215 $a1 online resource (iv, 177 pages) $cillustrations 225 1 $aEvidence-based Synthesis Program 300 $a"Evidence-based synthesis program." 300 $a"November 2012." 320 $aIncludes bibliographical references. 330 3 $aChronic ulcers (i.e., ulcers that are unresponsive to initial therapy or that persist despite appropriate care) are estimated to affect over 6 million people in the United States. The incidence is expected to increase as the population ages and as the number of individuals with diabetes increases. Chronic ulcers negatively affect the quality of life and productivity of the patient and represent a substantial financial burden to the health care system. Lower extremity ulcers, especially those attributed to either diabetes, venous disease, or arterial disease comprise a substantial proportion of chronic ulcers. Approximately 15% to 25% of individuals with diabetes develop a foot ulcer at some point in their lifetime and an estimated 12% of those patients require lower extremity amputation.^Healing is complicated by diabetic neuropathy and susceptibility to infection.^Venous disease accounts for the majority of chronic lower extremity ulcers.^Venous hypertension secondary to various cuases results in damage to vessel walls and ultimately leads to skin breakdown. Arterial ulcers are less common and are a result of impaired circulation which can affect healing lead to ulceration. Standard treatment for diabetic ulcers includes debridement of necrotic tissue, infection control, local ulcer care, mechanical off-loading, management of blood glucose levels, and education on foot care.^For venous ulcers, standard treatment typically includes the use of mechanical compression and limb elevation to reverse tissue edema and improve venous blood flow.^Care for ulcers caused by arterial insufficiency is centered on reestablishing blood flow and minimizing further loss of tissue perfusion.^If ulcers do not adequately heal with standard treatment, additional modalities may be required - these are often termed "advanced wound care therapies." Lower extremity ulcers are frequently classified etiologically as diabetic, venous or arterial, though overlap may exist. Treatment modalities and wound care therapies are often selected based on the ulcer characteristics as well as patient factors, past treatment, and provider preference.^A large and growing array of advanced wound care therapies of different composition and indications have been developed though their efficacy, comparative effectiveness and harm is not well established.^The purpose of this review is to synthesize the evidence on therapies for non-healing diabetic, venous, and arterial lower extremity ulcers.^This work was nominated by Rajiv Jain, MD (Chief Consultant, Office of Patient Care Services) and Jeffrey Robbins, DPM (Director, Podiatry Service) and is intended to provide an evidence base to guide clinical practice and policy needs within the VA. We recognize that a non-healing ulcer is likely a result of multiple factors and comorbid conditions. We group studies in the review according to the study authors' description of the included ulcer type. The review focuses on FDA-approved therapies and examines clinically relevant outcomes. 410 0$aEvidence-based synthesis program (Series) 606 $aDiabetes$xComplications 606 $aLeg$xUlcers 607 $aUnited States$2fast 608 $aTechnical reports.$2lcgft 615 0$aDiabetes$xComplications. 615 0$aLeg$xUlcers. 676 $a616.462 700 $aGreer$b Nancy$01353453 712 02$aUnited States.$bDepartment of Veterans Affairs.$bHealth Services Research and Development Service, 712 02$aQuality Enhancement Research Initiative (U.S.) 712 02$aMinneapolis VA Health Care System (U.S.).$bVA Evidence Synthesis Program. 712 02$aEvidence-based Synthesis Program (U.S.) 801 0$bNjHacI 801 1$bNjHacl 906 $aBOOK 912 $a9910717369603321 996 $aAdvanced wound care therapies for non-healing diabetic, venous, and arterial ulcers$93254401 997 $aUNINA