LEADER 03255nam 2200481 450 001 9910717345803321 005 20221101231814.0 035 $a(CKB)2670000000429429 035 $a(NjHacI)992670000000429429 035 $a(OCoLC)794257303$z(OCoLC)774399813 035 $a(EXLCZ)992670000000429429 100 $a20221101d2012 uy 0 101 0 $aeng 135 $aur||||||||||| 181 $ctxt$2rdacontent 182 $cc$2rdamedia 183 $acr$2rdacarrier 200 10$aNutritional supplements for age-related macular degeneration $ea systematic review /$fDevan Kansagara [and four others] 210 1$aWashington, DC :$cDept. of Veterans Affairs, Health Services Research & Development Service,$d[2012] 210 4$dİ2012 215 $a1 online resource (iv, 43 pages) $cillustrations 225 1 $aEvidence-based Synthesis Program 300 $a"Evidence-based synthesis program." 300 $a"January 2012." 320 $aIncludes bibliographical references. 330 3 $aAge-related macular degeneration (AMD) is the leading cause of irreversible vision loss in the developed world. In 2004, AMD affected 1.75 million persons in the United States, a number that is expected to rise to nearly 3 million by 2020 due to the aging of the population. The severity of macular degeneration ranges from Category 1 (least severe) to Category 4 (most severe), and "advanced AMD" is defined as having geographic atrophy involving the center of the macula or features of choroidal neovascularization. Observational studies suggest that people with dietary intakes higher in various carotenoids, antioxidants and omega-3 fatty acids have a lower risk of developing AMD. This has led to several supplementation trials designed to examine the ability of nutritional supplement with carotenoids, antioxidants, or omega-3 fatty acids to prevent the progression of AMD. Our report focuses on the evidence documenting the potential benefits and harms of certain dietary supplements in patients with AMD. We conducted a systematic review of published literature to address the following key questions: In patients with age-related macular degeneration, do nutritional supplements containing carotenoids, antioxidants, or omega-3 fatty acids alone or in combination prevent functional visual loss? In adult populations, what are the harms of carotenoid, antioxidant, and omega-3 fatty acid supplementation? 410 0$aEvidence-based synthesis program (Series) 517 $aNutritional supplements for age-related macular degeneration 606 $aRetinal degeneration$xAge factors 607 $aUnited States$2fast 608 $aTechnical reports.$2lcgft 615 0$aRetinal degeneration$xAge factors. 676 $a617.735 700 $aKansagara$b Devan$01351781 712 02$aUnited States.$bDepartment of Veterans Affairs.$bHealth Services Research and Development Service, 712 02$aPortland VA Medical Center.$bEvidence-based Synthesis Program Center. 712 02$aEvidence-based Synthesis Program (U.S.) 801 0$bNjHacI 801 1$bNjHacl 906 $aBOOK 912 $a9910717345803321 996 $aNutritional supplements for age-related macular degeneration$93275654 997 $aUNINA