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Semaphorin Receptors and their Signaling -- 2. Semaphorin Regulation of Neural Circuit Assembly in the Central Nervous System -- 3. Axon Guidance in the Spinal Cord -- 4. Semaphorin and Neuronal Migration in the Central Nervous System -- 5. Structure of Semaphorins and their Receptors -- 6. Regulation of Angiogenesis and Tumor Progression by Semaphorins -- 7. Semaphorins in the Immune System -- 8. Semaphorins in Bone Homeostasis -- 9. Semaphorin in the Heart -- 10. Semaphorins and Neurodegenerative Disorders -- 11. Semaphorin in the Retinal System. 330 $aThis book presents the current concepts of semaphorin biology. In the early 1990s, semaphorins were originally identified as axon guidance cues that function during neuronal development. However, cumulative findings have clarified that they have diverse functions in many physiological processes, including cardiogenesis, angiogenesis, vasculogenesis, osteoclastogenesis, retinal homeostasis, and immune regulation. 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