LEADER 03498nam 2200589Ia 450 001 9910144093303321 005 20180702173038.0 010 $a1-281-84052-1 010 $a9786611840525 010 $a0-470-69740-7 010 $a0-470-69741-5 035 $a(CKB)1000000000551489 035 $a(EBL)366846 035 $a(OCoLC)437234437 035 $a(SSID)ssj0000136162 035 $a(PQKBManifestationID)11150469 035 $a(PQKBTitleCode)TC0000136162 035 $a(PQKBWorkID)10064010 035 $a(PQKB)11282680 035 $a(MiAaPQ)EBC366846 035 $a(EXLCZ)991000000000551489 100 $a20080305d2008 uy 0 101 0 $aeng 135 $aur|n|---||||| 181 $ctxt 182 $cc 183 $acr 200 00$aDefining optimal immunotherapies for type 1 diabetes$b[electronic resource] /$f[editors: Gregory Bock and Jamie Goode] 210 $aLondon $cNovartis Foundation$d2008 215 $a1 online resource (224 p.) 225 1 $aNovartis Foundation symposium ;$vv. 292 300 $aDescription based upon print version of record. 311 $a0-470-72325-4 320 $aIncludes bibliographical references and index. 327 $aDefining Optimal Immunotherapies for Type 1 Diabetes; Contents; Participants; Chair's introduction; Pancreatic pathology in type 1 diabetes in human; The b cell population in type 1 diabetes; Bone marrow expressing a diabetes resistance MHC class II allele: diabetes deviation by chronic immune stimulation; Resuscitating adaptive Tregs with combination therapies?; Cytotoxic T cell mechanisms of b cell destruction in non-obese diabetic mice; Type 1 diabetes: chronic progressive autoimmune disease; Current and past prevention and intervention trials in type 1 diabetes 327 $aCD8 and cytotoxic T cells in type 1 diabetesGeneral discussion I; General discussion II; Genetic and therapeutic control of diabetogenic CD8+ T cells; General discussion III; Towards a curative therapy in type 1 diabetes: remission of autoimmunity, maintenance and augmentation of b cell mass; Immune markers of disease and therapeutic intervention in type 1 diabetes; Re-establishing immune tolerance in type 1 diabetes via regulatory T cells; Translating mucosal antigen based prevention of autoimmune diabetes to human; Closing remarks; Contributor index; Subject index 330 $aThis book is a comprehensive and up-to-date account of where we stand in immunological strategies for preventing or treating type 1 diabetes (T1D).Brings together contributions from the leaders in the arena of clinical immunotherapy, not limited to the diabetes field exclusively, in order to delineate a road-map that would lead to future clinical trials.The book integrates information from human and animal studies.The book considers T1D within the broader context of autoimmune disease.The format contains several discussions, which address specific questions and provides 410 0$aNovartis Foundation symposium ;$vv. 292. 606 $aDiabetes$xImmunotherapy$vCongresses 606 $aDiabetes$xTreatment$vCongresses 608 $aElectronic books. 615 0$aDiabetes$xImmunotherapy 615 0$aDiabetes$xTreatment 676 $a616.46206 712 02$aNovartis Foundation. 801 0$bMiAaPQ 801 1$bMiAaPQ 801 2$bMiAaPQ 906 $aBOOK 912 $a9910144093303321 996 $aDefining optimal immunotherapies for type 1 diabetes$92186506 997 $aUNINA LEADER 01513aam 2200421I 450 001 9910710067003321 005 20151118015322.0 024 8 $aGOVPUB-C13-82398a502438b86ec06d711a4ac53a5f 035 $a(CKB)5470000002475605 035 $a(OCoLC)929881125 035 $a(EXLCZ)995470000002475605 100 $a20151118d1973 ua 0 101 0 $aeng 181 $2rdacontent 182 $2rdamedia 183 $2rdacarrier 200 10$aUS/UK joint complementary research program in building, (wind loads, water supply, fire detection), July 1972- June 1973 /$fC. C. Raley; I. A. Benjamin; R. D. Marshall; J. E. Snell 210 1$aGaithersburg, MD :$cU.S. Dept. of Commerce, National Institute of Standards and Technology,$d1973. 215 $a1 online resource 225 1 $aNBSIR ;$v74-497 300 $a1973. 300 $aContributed record: Metadata reviewed, not verified. Some fields updated by batch processes. 300 $aTitle from PDF title page. 320 $aIncludes bibliographical references. 517 $aUS/UK joint complementary research program in building, 700 $aRaley$b C. C$01402058 701 $aBenjamin$b I. A$01395587 701 $aMarshall$b Richard D$01391285 701 $aRaley$b C. C$01402058 701 $aSnell$b J. 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Decision-making -- Chapter 5. Access to health services -- Chapter 6. Providing holistic care -- Chapter 7. Psychotropic medication -- Chapter 8. Death and dying -- Chapter 9. Staying healthy -- Chapter 10. Sources of advice about our health or that of others. 330 $aThis textbook presents a practical guide for new and experienced health or social care staff, helping them promote the health and well-being of people with learning disabilities. Given the considerable demand for mandatory training on supporting people with learning disabilities, especially in England, the book provides a valuable resource for all training courses on working with people with learning disabilities. The chapters are co-written by practitioners and people with learning disabilities and their families, rooting the book in the lived experiences of those concerned. Topics covered include core elements of being happy and healthy, communication, changes in our behaviour when we are unwell, making decisions about our health, accessing health services, how we would want to be treated if we were unwell, the use of psychotropic medication, what a ?good death? would be, and how to keep ourselves healthy. In addition, the chapters include narrative examples concerning people with learning disabilities and their families, so as to highlight key points and share best-practice examples. The use of personal reflection is used to consider how we can ensure that people with learning disabilities receive care and support that matches what we would expect for ourselves. Core questions at the end of each chapter ask the reader to reflect on how the chapter content relates to their own work and how they will apply what they have learned. A consistent theme throughout the book is equality of opportunity for people with learning disabilities to achieve good health. There is now substantial evidence that people with learning disabilities have poorer health than the general population, are more likely to have multiple health needs, and can experience difficulties in having their illnesses diagnosed and treated promptly. 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