LEADER 01685aam 2200481I 450 001 9910709524003321 005 20151026025818.0 024 8 $aGOVPUB-C13-8be82af5e3da4cb0019535e7b6237d9e 035 $a(CKB)5470000002479764 035 $a(OCoLC)926741149 035 $a(EXLCZ)995470000002479764 100 $a20151026d1975 ua 0 101 0 $aeng 181 $2rdacontent 182 $2rdamedia 183 $2rdacarrier 200 10$aCritical surveys of data sources $eceramics /$fDorothea M. Johnson, James F. Lynch 210 1$aGaithersburg, MD :$cU.S. Dept. of Commerce, National Institute of Standards and Technology,$d1975. 215 $a1 online resource 225 1 $aNBS special publication ;$v396-2 300 $a1975. 300 $aContributed record: Metadata reviewed, not verified. Some fields updated by batch processes. 300 $aTitle from PDF title page. 320 $aIncludes bibliographical references. 517 $aCritical surveys of data sources 606 $aCeramics$vBibliography 606 $aCeramics$xInformation services$vDirectories 606 $aCeramics$xSocieties, etc$vDirectories 608 $aBibliographies.$2lcgft 615 0$aCeramics 615 0$aCeramics$xInformation services 615 0$aCeramics$xSocieties, etc. 700 $aJohnson$b Dorothea M$01418057 701 $aJohnson$b Dorothea M$01418057 701 $aLynch$b James F.$f1918-$01418058 712 02$aUnited States.$bNational Bureau of Standards. 801 0$bNBS 801 1$bNBS 801 2$bGPO 906 $aBOOK 912 $a9910709524003321 996 $aCritical surveys of data sources$93528371 997 $aUNINA LEADER 04209nam 2200637 a 450 001 9910437857203321 005 20250423004911.0 010 $a9781461447443 010 $a1461447445 024 7 $a10.1007/978-1-4614-4744-3 035 $a(CKB)2670000000277906 035 $a(EBL)1030855 035 $a(OCoLC)818827910 035 $a(SSID)ssj0000799121 035 $a(PQKBManifestationID)11462981 035 $a(PQKBTitleCode)TC0000799121 035 $a(PQKBWorkID)10762910 035 $a(PQKB)11626158 035 $a(DE-He213)978-1-4614-4744-3 035 $a(MiAaPQ)EBC1030855 035 $a(PPN)168301091 035 $a(EXLCZ)992670000000277906 100 $a20120907d2013 uy 0 101 0 $aeng 135 $aur|n|---||||| 181 $ctxt 182 $cc 183 $acr 200 00$aRNA interference from biology to therapeutics /$fKenneth A. Howard, editor 205 $a1st ed. 2013. 210 $aNew York $cSpringer$d2013 215 $a1 online resource (347 p.) 225 0$aAdvances in delivery science and technology,$x2192-6204 300 $aDescription based upon print version of record. 311 08$a9781489993199 311 08$a1489993193 311 08$a9781461447436 311 08$a1461447437 320 $aIncludes bibliographical references and index. 327 $aRNA Interference Pathways and Therapeutic Exploitation RNA Interference -- Synthetic Dicer-Substrate siRNAs as Triggers of RNA Interference -- The Role of MicroRNAs in Natural Tissue Development and Application in Regenerative Medicine -- Intracellular Delivery Considerations for RNAi Therapeutics -- Mucosal Delivery of RNAi Therapeutics -- Nanomedicines for Systemic Delivery of RNAi Therapeutics -- Lipidoids: A Combinatorial Approach to siRNA Delivery -- Polymeric Micelles for siRNA Delivery -- RNAi Therapeutic Delivery by Exosomes -- Aptamer-Mediated siRNA Targeting -- RNAi as Anti-Viral Therapy: The HIV-1 Case -- Genome-Wide RNAi Screen for Identification of Human Host Factors Crucial for Influenza Virus Replication -- The Application of microRNAs in Cancer Diagnostics -- Therapeutic Application of miRNAs in Cancer -- Clinical Development of an Inhalable Anti-RSV siRNA Treatment. 330 $aThe Nobel Prize winning discovery that small interfering RNA can be utilised to control cellular gene expression has propelled the field of RNA interference (RNAi) to the forefront of biomedical science as a potential molecular medicine set to revolutionalise disease treatment.   Harnessing the molecular mechanisms of RNAi and development of delivery technologies is crucial for its transformation into a therapeutic modality, this dependency is the focus of ?RNA Interference from Biology to Therapeutics? that gives a comprehensive overview of RNAi biology and state-of-the-art delivery methods relevant to clinical translation of RNAi therapeutics. Key players and shapers in the fields of RNAi and delivery science have been assembled in a single volume to produce a truly unique interdisciplinary text, making it a ?must-read? for both students and experts in, and at the interface of, RNAi, pharmaceutical science and medicine. An attractive feature is the ?future perspectives? section within each chapter that allows global leaders the opportunity to express their views on the direction the field is moving. Topics covered in the book include miRNA biology and therapeutic exploitation, exosome delivery and clinical translation. ?RNA Interference from Biology to Therapeutics? is an up-to-the-minute, highly informative and invaluable text for those actively involved or interested in this fascinating and high-impact field. 410 0$aAdvances in Delivery Science and Technology,$x2192-6204 606 $aRNA editing 606 $aGene silencing 615 0$aRNA editing. 615 0$aGene silencing. 676 $a572.88 686 $aWC 4460$2rvk 701 $aHoward$b Kenneth A$g(Kenneth Alan)$0111144 801 0$bMiAaPQ 801 1$bMiAaPQ 801 2$bMiAaPQ 906 $aBOOK 912 $a9910437857203321 996 $aRNA interference from biology to therapeutics$94202748 997 $aUNINA