LEADER 01227nam0-2200373---450- 001 990000326560203316 005 20051111171422.0 010 $a2-84050-156-2 035 $a0032656 035 $aUSA010032656 035 $a(ALEPH)000032656USA01 035 $a0032656 100 $a20010119d1999----||ita|0103 ba 101 $afre 102 $aFR 105 $a|||| ||||| 200 1 $aDialogue avec un revenant$e15. siècle$ftraduit et commenté par Claude Lecouteux 210 $aParis$cPresses de l'Universit de Paris-Sorbonne$d1999 215 $a150 p.$d21 cm 300 $aNome dell'A. ricavato da: Die deutsche Literatur des Mittelaters. Verfasserlexikon, t. 1., Berlin-New York, 1978, coll. 1142-1145 676 $a839.431 700 1$aBUSCHMANN,$bArnt$0542729 702 1$aLECOUTEUX,$bClaude 801 0$aIT$bUNFI$c20010104 912 $a990000326560203316 951 $aVII.2.A. 27(VI ps B 910)$b155294 L.M.$cVI ps B$d00008004 959 $aBK 969 $aUMA 979 $aTAMI$b40$c20010119$lUSA01$h1232 979 $c20020403$lUSA01$h1640 979 $aPATRY$b90$c20040406$lUSA01$h1623 979 $aCOPAT2$b90$c20051111$lUSA01$h1714 996 $aDialogue avec un revenant$9879961 997 $aUNISA LEADER 01443nam 2200445I 450 001 9910705776703321 005 20170614164059.0 035 $a(CKB)5470000002452637 035 $a(OCoLC)990066321 035 $a(EXLCZ)995470000002452637 100 $a20170614j199608 ua 0 101 0 $aeng 135 $aurbn||||||||| 181 $ctxt$2rdacontent 182 $cc$2rdamedia 183 $acr$2rdacarrier 200 10$aSTS-78 space shuttle mission report /$fprepared by Robert W. Fricke 210 1$aHouston, Texas :$cNational Aeronautics and Space Administration, Lyndon B. Johnson Space Center,$dAugust 1996. 215 $a1 online resource (59 unnumbered pages) 225 1 $aNASA-TM ;$v111224 300 $a"August 1996." 300 $a"NSTS-37409." 606 $aBooster rocket engines$2nasat 606 $aExternal tanks$2nasat 606 $aSolid propellant rocket engines$2nasat 606 $aSpace programs$2nasat 606 $aSpace Shuttle Main Engine$2nasat 615 7$aBooster rocket engines. 615 7$aExternal tanks. 615 7$aSolid propellant rocket engines. 615 7$aSpace programs. 615 7$aSpace Shuttle Main Engine. 700 $aFricke$b Robert W.$01414888 712 02$aLyndon B. Johnson Space Center, 801 0$bGPO 801 1$bGPO 906 $aBOOK 912 $a9910705776703321 996 $aSTS-78 space shuttle mission report$93515381 997 $aUNINA LEADER 04754nam 2200397z- 450 001 9910136400303321 005 20210212 035 $a(CKB)3710000000612088 035 $a(oapen)https://directory.doabooks.org/handle/20.500.12854/58038 035 $a(oapen)doab58038 035 $a(EXLCZ)993710000000612088 100 $a20202102d2014 |y 0 101 0 $aeng 135 $aurmn|---annan 181 $ctxt$2rdacontent 182 $cc$2rdamedia 183 $acr$2rdacarrier 200 00$aRegulation of immune system cell functions by protein kinase C 210 $cFrontiers Media SA$d2014 215 $a1 online resource (129 p.) 225 1 $aFrontiers Research Topics 311 08$a2-88919-326-8 330 $aMembers of the protein kinase C (PKC) family of Ser/Thr kinases are encoded by nine distinct but closely related genes, which give rise to more than 12 different protein isoforms via a mechanism of alternative RNA splicing. Most PKC proteins are ubiquitously expressed and participate in a plethora of functions in most cell types. A majority of PKC isoforms is also expressed in cells of the immune system in which they are involved in signal transduction downstream of a range of surface receptors, including the antigen receptors on T and B lymphocytes. PKC proteins are central to signal initiation and propagation, and to the regulation of processes leading to immune cell proliferation, differentiation, homing and survival. As a result, PKC proteins directly impact on the quality and quantity of immune responses and indirectly on the host resistance to pathogens and tendency to develop immune deficiencies and autoimmune diseases. A significant progress was made in recent years in understanding the regulation of PKC enzymes, their mechanism of action and their role in determining immunocyte behavior This volume reviews the most significant contributions made in the field of immune cell regulation by PKC enzymes. Several manuscripts are devoted to the role of distinct PKC isoforms in the regulation of selected immunocyte responses. Additional manuscripts review more general mechanisms of regulation of PKC enzymes, either by post-translational modifications, such as phosphorylation or controlled proteolysis, or by interaction with different binding proteins that may alter the conformation, activity and subcellular location of PKC. Both types of mechanisms can introduce conformational changes in the molecule, which may affect its ability to interact with cofactors, ATP, or substrates. This topic will be followed by a discussion on the positive and negative impact of individual PKC isoforms on cell cycle regulation. A second section of this volume concentrates on selected topics relevant to role of the novel PKC isoform, PKC-theta, in T lymphocyte function. PKC-theta plays important and some non-redundant roles in T cell activation and is a key isoform that recruits to the immunological synapse - the surface membrane area in T cells that comes in direct contact with antigen presenting cells. The immunological synapse is formed in T cells within seconds following the engagement of the TCR by a peptide-bound MHC molecule on the surface of antigen-presenting cells. It serves as a platform for receptors, adaptor proteins, and effector molecules, which assemble into multimolecular activation complexes required for signal transduction. The unique ability of PKC-theta to activate the NF-kB, AP-1 and NF-AT transcription factors is well established, and recent studies contributed essential information on the mechanisms involved in the recruitment of PKC-theta to the center of the immunological synapse and the nature of its substrates and the role of their phosphorylated forms in signal transduction. Additional review manuscripts will describe the unique behavior of PKC-theta in regulatory T cells and its role in the regulation of other cell populations, including those of the innate immune response. This volume brings together leading experts from different disciplines that review the most recent discoveries and offer new perspectives on the contributions of PKC isoforms to biochemical processes and signaling events in different immune cell populations and their impact on the overall host immune response. 606 $aMedicine$2bicssc 610 $acell growth regulation 610 $alymphocyte stimulation 610 $aProtein Kinase C 610 $asignal transduction pathways 610 $aT cell activation 615 7$aMedicine 700 $aAmnon Altman$4auth$01277564 702 $aNoah Isakov$4auth 906 $aBOOK 912 $a9910136400303321 996 $aRegulation of immune system cell functions by protein kinase C$93011642 997 $aUNINA