LEADER 03974nam 2200457 450 001 9910427683103321 005 20210225125619.0 010 $a981-15-7918-0 024 7 $a10.1007/978-981-15-7918-9 035 $a(CKB)4100000011477040 035 $a(MiAaPQ)EBC6357807 035 $a(DE-He213)978-981-15-7918-9 035 $a(PPN)250221683 035 $a(EXLCZ)994100000011477040 100 $a20210225d2020 uy 0 101 0 $aeng 135 $aurnn|008mamaa 181 $ctxt$2rdacontent 182 $cc$2rdamedia 183 $acr$2rdacarrier 200 10$aNovel Coronavirus 2019 $ein-silco vaccine design and drug discovery /$fAmit Kumar [and four others] 205 $a1st ed. 2020. 210 1$aGateway East, Singapore :$cSpringer,$d[2020] 210 4$dİ2020 215 $a1 online resource (IX, 78 p. 83 illus., 51 illus. in color.) 225 1 $aSpringerBriefs in applied sciences and technology. Forensic and medical bioinformatics 311 $a981-15-7917-2 327 $a1. COVID19 and The Novel Corona Virus 2019 -- 2. The Genomic and Evolutionary Studies of Novel Corona Virus 2019 -- 3. Comparative proteomic analysis of NCoV and MERS Corona Virus -- 4. Physiochemical Characterization and Domain annotation of ORF1ab polyprotein of Novel Corona Virus 19 -- 5. Docking studies of the RNA dependent RNA polymerase domain of ORF1AB protein with the selected ligands of Novel Coronavirus 19 -- 6. Noted Herbs in the Treatment of COVID19 and Improving Human Immunity -- 7. Architecture of COVID-19 and SARS CoV-spike structural and functional aspects with ACE2 receptor: In-Silico analysis -- 8. Plasma Therapy towards COVID treatment -- 9. Identification and analysis of Possible Vaccine Candidates for COVID19 -- 10. Development of KITS for Rapid Diagnosis of COVID19. 330 $aThis book highlights the genomic findings, observations, and analysis of DNA/RNA sequences and protein structure of the dreadful virus of this decade- COVID-19. The Corona group of viruses though known species, the strain that caused the Pandemic of 2019 is a completely new strain, belonging to the same corona family with a novel genetic make-up. This makes it a new pathogen which is causing the current outbreak leaving the global scientific community clueless of any therapeutic breakthrough. NCOV enjoys life threatening pathogenicity with mysterious genetic annotations. This book details and offers insights into its viral genetic arrangement, Virulence factors, probable mutations leading to the evolution of this new strain and more. It contains chapters on Virus evolutionary status and Genetic makeup leading to its pathogenicity which can be a new insight in understanding the nature of this clever microorganism and can pave way to the development of new drugs and Vaccines or a novel diagnostic approach for the early prognosis of the disease. A dedicated chapter on annotation of NCOV-19 virulence genes, translation of the genes to protein product, annotation of the antigenic sites on these proteins is also included. In all, this brief is a complete genomic annotation insight of NCOV-19 using AI, Data analytics and Bioinformatics analysis. In the current situation, this book is an extensive preliminary resource for Medical practitioners, Researchers, Academicians, Scientists, Biochemists, Bioinformaticians and other professionals interested in understanding the genetics of Novel Coronavirus 19, the best possible drug targets, ideal vaccine candidates and novel prognostic and diagnostic biomarkers. 410 0$aSpringerBriefs in applied sciences and technology. Forensic and medical bioinformatics. 606 $aCOVID-19 (Disease) 615 0$aCOVID-19 (Disease) 676 $a616.2414 700 $aKumar$b Amit$f1976-$0993673 801 0$bMiAaPQ 801 1$bMiAaPQ 801 2$bMiAaPQ 906 $aBOOK 912 $a9910427683103321 996 $aNovel Coronavirus 2019$92275313 997 $aUNINA LEADER 01512nam 2200385 450 001 9910704762003321 005 20130731154349.0 035 $a(CKB)5470000002444104 035 $a(OCoLC)854766664 035 $a(EXLCZ)995470000002444104 100 $a20130731d2013 ua 0 101 0 $aeng 135 $aurmn||||||||| 181 $2rdacontent 182 $2rdamedia 183 $2rdacarrier 200 10$aDefense infrastructure $eNavy's analysis of costs and benefits regarding Naval Station Mayport demonstrated some best practices and minimally addressed other requirements : report to congressional committees 210 1$a[Washington, D.C.] :$cUnited States Government Accountability Office,$d2013. 215 $a1 online resource (ii, 20 pages) $cillustrations 300 $aTitle from title screen (viewed July 16, 2013). 300 $a"May 2013." 300 $a"GAO-13-501." 320 $aIncludes bibliographical references. 517 $aDefense infrastructure 606 $aDestroyers (Warships)$zUnited States$xMaintenance and repair$xCost effectiveness 606 $aNavy-yards and naval stations$zUnited States$xCost effectiveness 607 $aNaval Station Mayport (Fla.) 615 0$aDestroyers (Warships)$xMaintenance and repair$xCost effectiveness. 615 0$aNavy-yards and naval stations$xCost effectiveness. 801 0$bGPO 801 1$bGPO 906 $aBOOK 912 $a9910704762003321 996 $aDefense infrastructure$93422856 997 $aUNINA