LEADER 03631nam 22006975 450 001 9910703473503321 005 20250801073448.0 010 $a1-4615-5901-4 024 7 $a10.1007/978-1-4615-5901-6 035 $a(CKB)3390000000041086 035 $a(SSID)ssj0001086182 035 $a(PQKBManifestationID)11690895 035 $a(PQKBTitleCode)TC0001086182 035 $a(PQKBWorkID)11056153 035 $a(PQKB)10638506 035 $a(DE-He213)978-1-4615-5901-6 035 $a(MiAaPQ)EBC5588150 035 $a(MiAaPQ)EBC6491770 035 $a(Au-PeEL)EBL5588150 035 $a(OCoLC)1066197055 035 $a(OCoLC)1003050715 035 $a(EXLCZ)993390000000041086 100 $a20110811d1997 u| 0 101 0 $aeng 135 $aurnn|008mamaa 181 $ctxt 182 $cc 183 $acr 200 10$aCholesterol $eIts Functions and Metabolism in Biology and Medicine /$fedited by Robert Bittman 205 $a1st ed. 1997. 210 1$aNew York, NY :$cSpringer US :$cImprint: Springer,$d1997. 215 $a1 online resource (XXVIII, 548 p.) 225 1 $aSubcellular Biochemistry,$x2542-8810 ;$v28 300 $aIncludes index. 311 08$a0-306-45478-5 311 08$a1-4613-7707-2 327 $a1 Signaling Molecules Derived from the Cholesterol Biosynthetic Pathway -- 2 Coordinate Regulation of Cholesterol 7?-Hydroxylase and HMG-CoA Reductase in the Liver -- 3 Polyprenyl Diphosphate Synthases -- 4 Antifungal Sterol Biosynthesis Inhibitors -- 5 The Smith-Lemli-Opitz Syndrome: A Potentially Fatal Birth Defect Caused by a Block in the Last Enzymatic Step in Cholesterol Biosynthesis -- 6 Has Nature Designed the Cholesterol Side Chain for Optimal Interaction with Phospholipids? -- 7 Cholesterol and Myelin -- 8 Regulation of Mitochondrial Cholesterol Metabolism -- 9 Lipoproteins and Cellular Cholesterol Homeostasis -- 10 Cholesterol-Sphingomyelin Interactions in Cells?Effects on Lipid Metabolism -- 11 Mechanisms and (Patho)Physiological Significance of Biliary Cholesterol Secretion -- 12 Cholesterol Deposition in Atherosclerotic Lesions -- 13 Cholesterol Metabolism and Tumor Cell Proliferation -- 14 Biological Implications of the Niemann-Pick C Mutation -- 15 Sitosterolemia -- 16 Cholesterol Cytochemistry in Cell Biology and Disease -- 17 Approaches for the Design of Novel Anti-Atherogenic Compounds. 330 $aExperts investigate the biochemical and biomedical aspects of cholesterol, addressing its metabolism in normal and disease states. They discuss a broad range of topics, including key steps in the cholesterol biosynthetic pathway, and the role of cholesterol in cancer, atherosclerosis, and diseases of the nervous system. The book's comprehensive coverage also includes the pathological consequences and potential therapies for various disease states, and the development of new anti-atherogenic drugs. 410 0$aSubcellular Biochemistry,$x2542-8810 ;$v28 606 $aBiochemistry 606 $aAnatomy, Comparative 606 $aBotany 606 $aBiochemistry 606 $aAnimal Anatomy 606 $aPlant Science 615 0$aBiochemistry. 615 0$aAnatomy, Comparative. 615 0$aBotany. 615 14$aBiochemistry. 615 24$aAnimal Anatomy. 615 24$aPlant Science. 676 $a612.12 702 $aBittman$b Robert 712 02$aUnited States.$bFood and Drug Administration.$bOffice of Women's Health, 801 0$bMiAaPQ 801 1$bMiAaPQ 801 2$bMiAaPQ 906 $aBOOK 912 $a9910703473503321 996 $aCholesterol$92028951 997 $aUNINA