LEADER 05405nam 2200697 a 450 001 9910465114403321 005 20200520144314.0 010 $a1-118-27214-5 010 $a1-118-36970-X 035 $a(CKB)2560000000100661 035 $a(EBL)1143558 035 $a(OCoLC)830161787 035 $a(SSID)ssj0000833801 035 $a(PQKBManifestationID)12346717 035 $a(PQKBTitleCode)TC0000833801 035 $a(PQKBWorkID)10935881 035 $a(PQKB)10293600 035 $a(MiAaPQ)EBC1143558 035 $a(JP-MeL)3000046274 035 $a(PPN)22019968X 035 $a(Au-PeEL)EBL1143558 035 $a(CaPaEBR)ebr10671551 035 $a(CaONFJC)MIL462833 035 $a(EXLCZ)992560000000100661 100 $a20121108d2013 uy 0 101 0 $aeng 135 $aur|n|---||||| 181 $ctxt 182 $cc 183 $acr 200 10$aOncology at a glance$b[electronic resource] /$fGraham G. Dark 210 $aChichester, West Sussex, U.K. $cWiley-Blackwell$d2013 215 $a1 online resource (138 p.) 225 1 $aAt a glance 300 $aDescription based upon print version of record. 311 $a1-118-36969-6 320 $aIncludes bibliographical references and index. 327 $aCover; Title page; Copyright page; Contents; Contributors; Preface; Abbreviations; 1: The global burden of cancer; The global burden of cancer; Developed and developing countries; Tobacco; Lifestyle; Infections; Challenges; 2: The nomenclature of oncology; Tumour nomenclature; Tumour grade; Cytology; Cytogenetic analysis; Tumour stage; Performance status; 3: Environmental determinants of cancer; Environmental factors; Radiation; Chemicals; Smoking; Infections; Hormones; Nutrition and lifestyle; 4: The hallmarks of cancer I; The 10 hallmarks of cancer; 1. Genome instability and mutation 327 $a2. Resisting cell death5: The hallmarks of cancer II; 3. Sustaining proliferative signalling; The cell cycle; Cell cycle regulation; Stimulation of the cell cycle; 4. Evading growth suppressors; 5. Enabling replicative immortality; 6: The hallmarks of cancer III; 6. Inducing angiogenesis; 7. Activating invasion and metastasis; 7: The hallmarks of cancer IV; 8. Reprogramming energy metabolism; 9. Tumour-promoting inflammation; 10. Evading immune destruction; 8: Cancer genetics and inherited cancer; Principles of cancer genetics; How genes cause cancer; Oncogenes; Tumour suppressor genes 327 $aMultistep carcinogenesisInherited cancer syndromes; Autosomal dominant cancer syndromes; Autosomal recessive cancer syndromes; 9: Communicating with cancer patients; Communicating with cancer patients; The doctor-patient relationship; Breaking bad news; Steps to breaking bad news; Dealing with the emotional patient; Communicating with younger patients; 10: Presenting problems in a patient with cancer; Presenting features of cancer; General features on examination; Local effects; Change of function; Obstruction of a conduit; Metastatic effects; 11: Paraneoplastic syndromes 327 $aEctopic hormone productionNeurological manifestations; Cutaneous manifestations; Haematological manifestations; Gastrointestinal manifestations; Renal manifestations; Other paraneoplastic syndromes; 12: Metabolic emergencies in cancer patients; Hypercalcaemia; Syndrome of inappropriate antidiuresis; Hypomagnesaemia; Tumour lysis syndrome; 13: Oncological emergencies; Neutropenic sepsis; Superior vena cava obstruction; Spinal cord compression; 14: Investigation and management of metastatic disease; Brain metastases; Lung metastases; Liver metastases; Bone metastases; Malignant pleural effusion 327 $aMalignant ascitesOther sites; 15: Tumour markers; Serum proteins; Clinical usefulness; Human chorionic gonadotrophin; Alpha-fetoprotein; Placental alkaline phosphatase; CA19-9; Inhibin; Carcinoembryonic antigen (CEA); CA15-3; CA125; Squamous cell carcinoma-associated antigen (SCC); Prostate-specific antigen (PSA); Hormones; 16: Screening for cancer; Successful screening; Lead time bias; Length time bias; Breast cancer screening; Colorectal cancer screening; Gastric cancer screening; Prostate cancer screening; Cervical cancer screening; Ovarian cancer screening; Lung cancer screening 327 $aThe future 330 $a This brand new title in the market-leading at a Glance series brings together fundamental information on cancer biology and treatment to provide a holistic understanding of oncology. 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