LEADER 03008oam 2200625I 450 001 9910459189503321 005 20200520144314.0 010 $a0-429-19186-3 010 $a1-282-90323-3 010 $a9786612903236 010 $a1-58488-985-3 024 7 $a10.1201/9781584889854 035 $a(CKB)2670000000048176 035 $a(EBL)599708 035 $a(OCoLC)663999016 035 $a(SSID)ssj0000423608 035 $a(PQKBManifestationID)11281037 035 $a(PQKBTitleCode)TC0000423608 035 $a(PQKBWorkID)10468412 035 $a(PQKB)10507151 035 $a(MiAaPQ)EBC599708 035 $a(Au-PeEL)EBL599708 035 $a(CaPaEBR)ebr10424663 035 $a(CaONFJC)MIL290323 035 $a(EXLCZ)992670000000048176 100 $a20180331d2010 uy 0 101 0 $aeng 135 $aur|n|---||||| 181 $ctxt 182 $cc 183 $acr 200 00$aMultiple testing problems in pharmaceutical statistics /$feditors, Alex Dmitrienko, Ajit C. Tamhane, Frank Bretz 210 1$aBoca Raton :$cChapman & Hall/CRC/Taylor & Francis,$d2010. 215 $a1 online resource (323 p.) 225 1 $aChapman & Hall/CRC biostatistics series ;$v33 300 $aDescription based upon print version of record. 311 $a1-58488-984-5 320 $aIncludes bibliographical references and index. 327 $aCover; Title; Copyright; Contents; Preface; List of Contributors; Chapter 1: Multiplicity Problems in Clinical Trials: A Regulatory Perspective; Chapter 2: Multiple Testing Methodology; Chapter 3: Multiple Testing in Dose-Response Problems; Chapter 4: Analysis of Multiple Endpoints in Clinical Trials; Chapter 5: Gatekeeping Procedures in Clinical Trials; Chapter 6: Adaptive Designs and Confirmatory Hypothesis Testing; Chapter 7: Design and Analysis of Microarray Experiments for Pharmacogenomics; Bibliography; Index 330 $aUseful Statistical Approaches for Addressing Multiplicity IssuesIncludes practical examples from recent trials Bringing together leading statisticians, scientists, and clinicians from the pharmaceutical industry, academia, and regulatory agencies, Multiple Testing Problems in Pharmaceutical Statistics explores the rapidly growing area of multiple comparison research with an emphasis on pharmaceutical applications. In each chapter, the expert contributors describe important multiplicity problems encountered in pre-clinical and clin 410 0$aChapman & Hall/CRC biostatistics series ;$v33. 606 $aDrugs$xTesting$xStatistical methods 608 $aElectronic books. 615 0$aDrugs$xTesting$xStatistical methods. 676 $a615/.1901 701 $aDmitrienko$b Alex$0858723 701 $aTamhane$b Ajit C$0102985 701 $aBretz$b Frank$0512836 801 0$bMiAaPQ 801 1$bMiAaPQ 801 2$bMiAaPQ 906 $aBOOK 912 $a9910459189503321 996 $aMultiple testing problems in pharmaceutical statistics$91916812 997 $aUNINA LEADER 01542nam 2200361Ia 450 001 996386003203316 005 20200824132707.0 035 $a(CKB)4940000000080241 035 $a(EEBO)2264197361 035 $a(OCoLC)ocm13150358e 035 $a(OCoLC)13150358 035 $a(EXLCZ)994940000000080241 100 $a19860213d1681 uy | 101 0 $aeng 135 $aurbn||||a|bb| 200 14$aThe questions between the conformist and nonconformist, truly stated, and briefly discussed$b[electronic resource] $eDr. Falkner, The friendly debate &c., examined and answered : together with a discourse about separation, and some animadversions upon Dr. Stillingfleet's book entituled, The unreasonableness of separation : observations upon Dr. Templers sermon preached at a visitation in Cambridge : a brief vindication of Mr. Stephen Marshal 210 $aLondon $cPrinted for Tho. Cockerill ...$d1681 215 $a[15], 105 p 300 $aDedicatory epistle signed: G.F. [i.e., Giles Firmin]. Cf. BM. 300 $aReproduction of original in Trinity College Library, Dublin. 300 $aMarginal notes. 330 $aeebo-0159 606 $aDissenters, Religious$zEngland 615 0$aDissenters, Religious 700 $aFirmin$b Giles$f1614-1697.$01001629 801 0$bEAA 801 1$bEAA 801 2$bm/c 801 2$bWaOLN 906 $aBOOK 912 $a996386003203316 996 $aThe questions between the conformist and nonconformist, truly stated, and briefly discussed$92412563 997 $aUNISA LEADER 01783oam 2200433 450 001 9910702209603321 005 20130501113920.0 035 $a(CKB)5470000002426057 035 $a(OCoLC)824752362 035 $a(OCoLC)995470000002426057 035 $a(EXLCZ)995470000002426057 100 $a20130122d2012 ua 0 101 0 $aeng 135 $aurcn||||||||| 181 $2rdacontent 182 $2rdamedia 183 $2rdacarrier 200 10$aSpatial and temporal trends in runoff at long-term streamgages within and near the Chesapeake Bay Watershed /$fby Karen C. Rice and Robert M. Hirsch ; prepared in cooperation with the Virginia Department of Environmental Quality, Office of Surface Water Investigations 210 1$aReston, Virginia. :$cU.S. Department of the Interior, U.S. Geological Survey,$d2012. 215 $a1 online resource (vi, 56 pages) $ccolor illustrations 225 1 $aScientific investigations report ;$v2012-5151 300 $aTitle from title screen (viewed on Dec. 3, 2012). 320 $aIncludes bibliographical references (page 24). 606 $aStream measurements$zChesapeake Bay Watershed 606 $aStreamflow$zChesapeake Bay Watershed 607 $aChesapeake Bay (Md. and Va.) 615 0$aStream measurements 615 0$aStreamflow 700 $aRice$b Karen C.$01381239 702 $aHirsch$b Robert M. 712 02$aVirginia.$bDepartment of Environmental Quality.$bOffice of Surface Water Investigations, 712 02$aGeological Survey (U.S.), 801 0$bGPO 801 1$bGPO 801 2$bGPO 906 $aBOOK 912 $a9910702209603321 996 $aSpatial and temporal trends in runoff at long-term streamgages within and near the Chesapeake Bay Watershed$93446425 997 $aUNINA