LEADER 01783oam 2200421 a 450 001 9910698791203321 005 20121220150528.0 035 $a(CKB)5470000002395942 035 $a(OCoLC)817733111 035 $a(EXLCZ)995470000002395942 100 $a20121113d2006 ua 0 101 0 $aeng 135 $aurmn||||||||| 181 $ctxt$2rdacontent 182 $cc$2rdamedia 183 $acr$2rdacarrier 200 10$aMACV$b[electronic resource] $ethe joint command in the years of escalation, 1962-1967 /$fby Graham A. Cosmas 210 1$aWashington, D.C. :$cCenter of Military History, United States Army :$cFor sale by the Supt. of Docs., U.S. G.P.O,$d2006. 215 $a1 online resource (xx, 524 pages) $cillustrations (some color), color maps 225 1 $aUnited States Army in Vietnam 225 1 $aCMH pub. ;$v91-6-1 300 $aTitle from title screen (viewed Nov. 13, 2012). 311 $a0-16-072367-1 320 $aIncludes bibliographical references and index. 327 $aA Deepening Commitment and a New Command -- A Joint Command: Complications and Conflicts, 1962-1963 -- From Hope to Frustration -- Reorganizing and Reviving Pacification -- The Beginning of Escalation -- Beginnings of the Ground Troop Commitment, January-June 1965 -- The Fateful Decisions, June 1965-February 1966 -- MACV Headquarters -- Controlling U.S. Forces -- The Allies and Pacification. 517 $aMACV 606 $aVietnam War, 1961-1975$zUnited States 615 0$aVietnam War, 1961-1975 700 $aCosmas$b Graham A$01351953 712 02$aCenter of Military History. 801 0$bXBM 801 1$bXBM 801 2$bOCLCO 801 2$bGPO 906 $aBOOK 912 $a9910698791203321 996 $aMACV$93472363 997 $aUNINA LEADER 04295nam 2200625 a 450 001 9910437826803321 005 20200520144314.0 010 $a1-283-93528-7 010 $a3-642-33570-5 024 7 $a10.1007/978-3-642-33570-9 035 $a(CKB)2670000000317383 035 $a(EBL)1082699 035 $a(OCoLC)823728111 035 $a(SSID)ssj0000830652 035 $a(PQKBManifestationID)11470832 035 $a(PQKBTitleCode)TC0000830652 035 $a(PQKBWorkID)10820329 035 $a(PQKB)11065966 035 $a(DE-He213)978-3-642-33570-9 035 $a(MiAaPQ)EBC1082699 035 $a(PPN)168324873 035 $a(EXLCZ)992670000000317383 100 $a20121022d2013 uy 0 101 0 $aeng 135 $aur|n|---||||| 181 $ctxt 182 $cc 183 $acr 200 00$aBotulinum neurotoxins /$fAndreas Rummel, Thomas Binz, editors 205 $a1st ed. 2013. 210 $aNew York $cSpringer$d2013 215 $a1 online resource (321 p.) 225 1 $aCurrent topics in microbiology and immunology,$x0070-217X ;$vv. 364 300 $aDescription based upon print version of record. 311 $a3-642-44889-5 311 $a3-642-33569-1 320 $aIncludes bibliographical references and index. 327 $aGenetic Diversity Within Clostridium botulinum Serotypes, Botulinum Neurotoxin Gene Clusters and Toxin Subtypes -- Assembly and Function of the Botulinum Neurotoxin Progenitor Complex -- Uptake of Botulinum Neurotoxin in the Intestine -- Double Receptor Anchorage of Botulinum Neurotoxins Accounts for their Exquisite Neurospecificity -- The Elusive Compass of Clostridial Neurotoxins: Deciding When and Where to Go? -- Synchronized Chaperone Function of Botulinum Neurotoxin Domains Mediates Light Chain Translocation into Neurons -- Clostridial Neurotoxin Light Chains: Devices for SNARE Cleavage Mediated Blockade of Neurotransmission -- Synaptic Vesicle Proteins: Targets and Routes for Botulinum Neurotoxins -- Persistence of Botulinum Neurotoxin Inactivation of Nerve Function -- Structure-Based Drug Discovery for Botulinum Neurotoxins -- Complexity of Botulinum Neurotoxins: Challenges for Detection Technology -- Progress in Cell Based Assays for Botulinum Neurotoxin Detection -- Transforming the Domain Structure of Botulinum Neurotoxins into Novel Therapeutics -- Botulinum Toxin: Application, Safety, and Limitations. 330 $aBotulinum neurotoxins are the most toxic natural substances and represent a major threat to the population when intentionally released in bioterrorist attacks. On the other hand, during the past two decades botulinum neurotoxins have become established as indispensable drugs for the treatment of a variety of severe neurological disorders. The need for efficient countermeasures as well as the expansion into additional fields of therapeutic application, call for comprehensive information on the botulinum neurotoxin molecules and their mode of action. Our knowledge of this subject has made great strides in recent years, setting the stage for the development of new botulinum neurotoxin-based molecules and novel applications. This book reviews the current status of basic botulinum neurotoxin research. The first part describes the genetic variability of the toxin-producing bacteria, and sheds light on each step from toxin ingestion to the abrogation of synaptic signaling including the intestinal passage and absorption, nerve cell binding and entry, and intracellular substrate cleavage. The remaining chapters detail progress made in detection methods for botulinum neurotoxins, the development of botulinum neurotoxin inhibitors, and strategies to refine the neurotoxins for further medicinal applications by means of recombinant technologies. 410 0$aCurrent topics in microbiology and immunology ;$v364. 606 $aBotulinum toxin 606 $aNeurotoxic agents 615 0$aBotulinum toxin. 615 0$aNeurotoxic agents. 676 $a615.9/5 676 $a615.95 701 $aRummel$b Andreas$01761729 701 $aBinz$b Thomas$01761730 801 0$bMiAaPQ 801 1$bMiAaPQ 801 2$bMiAaPQ 906 $aBOOK 912 $a9910437826803321 996 $aBotulinum neurotoxins$94201339 997 $aUNINA