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010   $a981-19-5638-3
024 7 $a10.1007/978-981-19-5638-6
035   $a(CKB)5580000000531592
035   $a(DE-He213)978-981-19-5638-6
035   $a(PPN)269659064
035   $a(MiAaPQ)EBC31094154
035   $a(Au-PeEL)EBL31094154
035   $a(MiAaPQ)EBC7238789
035   $a(EXLCZ)995580000000531592
100   $a20230418d2023      u|         0
101 0 $aeng
135   $aurnn#008mamaa
181   $ctxt$2rdacontent
182   $cc$2rdamedia
183   $acr$2rdacarrier
200 10$aAntibody-Drug Conjugates and Cellular Metabolic Dynamics /$fedited by Shuqing Chen, Jinbiao Zhan
205   $a1st ed. 2023.
210  1$aSingapore :$cSpringer Nature Singapore :$cImprint: Springer,$d2023.
215   $a1 online resource (IX, 135 p. 1 illus.)
311 08$a981-19-5637-5 
320   $aIncludes bibliographical references.
327   $aAntibody-Drug Conjugates Basic Concepts and Structures -- Relationship between target and specific action of antibody-drugs conjugates -- The internalization and therapeutic activity of antibody drug conjugate -- The internalization and intracellular trafficking of ADC -- Distribution and metabolism of antibody-drug conjugates -- Application of Antibody fragments in ADCs -- Novel Targeting Carriers in Antibody-drug Conjugates -- Site-specified Conjugating Technology and Application -- Determination of drug-to-antibody ratio of ADCs -- Pharmacokinetic study of antibody-drug conjugates.
330   $aThis book summarizes the related research achievements in Antibody-drug conjugates (ADCs) and their cell metabolism kinetics. The book has three main parts. The first part describes the basic theory of ADCs, including the basic concept and structure of ADCs, and the relationship between the targets of ADCs and their specific functions. The second part mainly introduces the endocytosis and intracellular metabolism of ADCs, including the relationship between endocytosis and ADC activity, the endocytosis and intracellular transport of ADCs, the distribution and metabolism of ADC in vivo. Then it discusses the new formats and research technology of ADCs, including the application of miniaturized antibodies in ADC synthesis, novel carriers for ADC design, the technology and application of site-specific conjugation, and approaches for analyzing the drug: antibody ratio (DAR), the study of pharmacokinetics of ADCs. This book combines the basic theory with the research technology. It canbe used as a reference book for students, teachers and researchers of biomedical field.
606   $aBiology$xTechnique
606   $aExperimental immunology
606   $aPharmaceutical chemistry
606   $aMedicine$xResearch
606   $aBiology$xResearch
606   $aCytology
606   $aClinical biochemistry
606   $aImmunological Techniques
606   $aPharmaceutics
606   $aBiomedical Research
606   $aCell Biology
606   $aMedical Biochemistry
615  0$aBiology$xTechnique.
615  0$aExperimental immunology.
615  0$aPharmaceutical chemistry.
615  0$aMedicine$xResearch.
615  0$aBiology$xResearch.
615  0$aCytology.
615  0$aClinical biochemistry.
615 14$aImmunological Techniques.
615 24$aPharmaceutics.
615 24$aBiomedical Research.
615 24$aCell Biology.
615 24$aMedical Biochemistry.
676   $a615.36
702   $aChen$b Shuqing
702   $aZhan$b Jinbiao
801  0$bMiAaPQ
801  1$bMiAaPQ
801  2$bMiAaPQ
906   $aBOOK
912   $a9910698647603321
996   $aAntibody-Drug Conjugates and Cellular Metabolic Dynamics$93200507
997   $aUNINA