LEADER 05800nam 2200697 450 001 9910465176603321 005 20200520144314.0 010 $a1-4963-2454-4 010 $a1-4698-8863-7 035 $a(CKB)2560000000261878 035 $a(EBL)2035692 035 $a(SSID)ssj0001513478 035 $a(PQKBManifestationID)11874693 035 $a(PQKBTitleCode)TC0001513478 035 $a(PQKBWorkID)11462737 035 $a(PQKB)10837900 035 $a(MiAaPQ)EBC2035692 035 $a(Au-PeEL)EBL2035692 035 $a(CaPaEBR)ebr11292968 035 $a(OCoLC)908512925 035 $a(EXLCZ)992560000000261878 100 $a20140131h20152015 uy| 0 101 0 $aeng 135 $aur|n|---||||| 181 $ctxt 182 $cc 183 $acr 200 00$aHead and neck surgery$iSkull base surgery /$feditors, Carl H. Snyderman, MD, MBA, Professor, Departments of Otaryngology and Neurological Surgery, University of Pittsburgh School of Medicine, Co-Director, Center for Cranial Base Surgery, University of Pittsburgh Medical Center, Pittsburgh, Pennsylvania, Paul Gardner, MD, Department of Neurological Surgery, University of Pittsburgh School of Medicine, Co-Director, Center for Cranial Base Surgery, University of Pittsburgh Medical Center, Pittsburgh, Pennsylvania 205 $aFirst edition. 210 1$aPhiladelphia :$cWolters Kluwer,$d[2015] 210 4$dİ2015 215 $a1 online resource (490 p.) 225 1 $aMaster techniques in otolaryngology 300 $aDescription based upon print version of record. 311 $a1-4511-7362-8 320 $aIncludes bibliographical references and index. 327 $aMASTER TECHNIQUES IN OTOLARYNGOLOGY Head and Neck Surgery; Contributors; Preface; Contents; PART I: SPHENOID AND PARASELLAR REGIONS; 1OPTIC NERVE DECOMPRESSION; 2ENDONASAL APPROACH TO THE SELLA; 3ENDOSCOPIC ENDONASAL APPROACH TO THE SELLA FOR PITUITARY ADENOMAS AND RATHKE'S CLEFT CYSTS; 4TRANSCRANIAL APPROACHES TO THE SELLA, SUPRASELLAR, AND PARASELLAR AREA; 5ENDOSCOPIC ENDONASAL APPROACH TO THE MEDIAL CAVERNOUS SINUS; 6ENDONASAL SUPRASELLAR APPROACH; 7TRANSPTERYGOID APPROACH TO THE LATERAL RECESS OF THE SPHENOID SINUS; 8TRANSSPHENOIDAL APPROACH TO THE MEDIAL PETROUS APEX 327 $aPART II: ANTERIOR CRANIAL FOSSA9CRANIOTOMY FOR SUPRASELLAR TUMOR; 10PTERIONAL /ORBITAL-PTERIONAL CRANIOTOMY; 11ENDONASAL TRANSFRONTAL APPROACH TO THE ANTERIOR CRANIAL BASE; 12ENDONASAL TRANSCRIBRIFORM APPROACH TO THE ANTERIOR CRANIAL FOSSA; 13ENDONASAL TRANSPLANUM APPROACH TO THE ANTERIOR CRANIAL FOSSA; 14ENDONASAL TRANSORBITAL APPROACH TO THE ANTERIOR CRANIAL FOSSA; 15TRANSORBITAL ENDOSCOPIC APPROACHES TO THE ANTERIOR CRANIAL FOSSA; 16SUPRAORBITAL KEYHOLE APPROACH TO THE ANTERIOR CRANIAL FOSSA; 17ENDONASAL RESECTION OF THE ANTERIOR CRANIAL BASE 327 $a18TRANSCRANIAL APPROACH FOR ANTERIOR CRANIOFACIAL RESECTION19ANTERIOR CRANIOFACIAL RESECTION: ENDOSCOPIC ASSISTED; 20FACIAL TRANSLOCATION APPROACH TO THE CENTRAL CRANIAL BASE; 21 ANTERIOR CRANIOFACIAL RESECTION: MIDFACIAL DEGLOVING; 22 ANTERIOR CRANIOFACIAL RESECTION: LATERAL RHINOTOMY; 23ANTERIOR CRANIOFACIAL RESECTION: RAVEH TECHNIQUE; 24CRANIALIZATION OF THE FRONTAL SINUS; 25FRONTAL SINUS OSTEOPLASTIC FLAP WITH AND WITHOUT OBLITERATION; PART III: MIDDLE CRANIAL FOSSA; 26SUPRAPETROUS APPROACH TO THE LATERAL CAVERNOUS SINUS 327 $a27SUPRAPETROUS APPROACH TO MECKEL'S CAVE AND THE MIDDLE CRANIAL FOSSA28INFRAPETROUS APPROACH TO THE JUGULAR FORAMEN; 29SURGERY FOR ANGIOFIBROMA; 30MODIFIED ORBITOZYGOMATIC CRANIOTOMY; 31PREAURICULAR APPROACH TO THE INFRATEMPORAL SKULL BASE; 32ANTERIOR TRANSPETROSAL APPROACH TO THE MIDDLE CRANIAL FOSSA AND POSTERIOR CRANIAL FOSSA; 33POSTAURICULAR APPROACH TO THE INFRATEMPORAL SKULL BASE; 34TRANSORBITAL ENDOSCOPIC APPROACHES TO THE MIDDLE CRANIAL FOSSA; PART IV: POSTERIOR CRANIAL FOSSA; 35ENDOSCOPIC ENDONASAL PITUITARY TRANSPOSITION APPROACH TO THE SUPERIOR CLIVUS 327 $a36TRANSCLIVAL APPROACH TO THE MIDDLE AND LOWER CLIVUS37ENDOSCOPIC ENDONASAL APPROACH TO THE CRANIOCERVICAL JUNCTION AND ODONTOID; 38COMBINED SUPRAAND INFRATENTORIAL PRESIGMOID RETROLABYRINTHINE TRANSPETROSAL APPROACH; 39FAR LATERAL TRANSCERVICAL APPROACH TO THE LOWER CLIVUS AND UPPER CERVICAL SPINE; PART V: RECONSTRUCTION; 40NONVASCULARIZED REPAIR OF SMALL DURAL DEFECTS; 41NONVASCULARIZED REPAIR OF LARGE DURAL DEFECTS; 42NASOSEPTAL FLAP; 43MIDDLE TURBINATE FLAP; 44INFERIOR TURBINATE FLAP; 45THE TEMPOROPARIETAL FASCIAL FLAP IN SKULL BASE RECONSTRUCTION; 46EXTRACRANIAL PERICRANIAL FLAP 327 $a47TRANSCRANIAL PERICRANIAL FLAP 330 $aNow part of the Master Techniques in Otolaryngology - Head and Neck Surgery series, Skull Base Surgery is the new go-to guide on common and advanced procedures in skull base surgery. Step-by-step expert instruction is offered on more than 45 procedures, covering both open and minimally invasive approaches to the skull base. It is a vital resource for students, generalist surgeons, and skull base specialists in otolaryngology and neurosurgery. Key Features: authored by world-renowned experts and pioneers in open and endoscopic skull base approaches. Chapters that cover: introduction to each app 410 0$aMaster techniques in otolaryngology. 606 $aSkull base$xSurgery 606 $aCraniotomy 606 $aSurgery, Plastic 608 $aElectronic books. 615 0$aSkull base$xSurgery. 615 0$aCraniotomy. 615 0$aSurgery, Plastic. 676 $a617.5/14 702 $aSnyderman$b Carl H. 702 $aGardner$b Paul A$g(Paul Andrew),$f1973- 801 0$bMiAaPQ 801 1$bMiAaPQ 801 2$bMiAaPQ 906 $aBOOK 912 $a9910465176603321 996 $aHead and neck surgery$92124132 997 $aUNINA LEADER 03847nam 22007335 450 001 9910698647603321 005 20251008153515.0 010 $a981-19-5638-3 024 7 $a10.1007/978-981-19-5638-6 035 $a(CKB)5580000000531592 035 $a(DE-He213)978-981-19-5638-6 035 $a(PPN)269659064 035 $a(MiAaPQ)EBC31094154 035 $a(Au-PeEL)EBL31094154 035 $a(MiAaPQ)EBC7238789 035 $a(EXLCZ)995580000000531592 100 $a20230418d2023 u| 0 101 0 $aeng 135 $aurnn#008mamaa 181 $ctxt$2rdacontent 182 $cc$2rdamedia 183 $acr$2rdacarrier 200 10$aAntibody-Drug Conjugates and Cellular Metabolic Dynamics /$fedited by Shuqing Chen, Jinbiao Zhan 205 $a1st ed. 2023. 210 1$aSingapore :$cSpringer Nature Singapore :$cImprint: Springer,$d2023. 215 $a1 online resource (IX, 135 p. 1 illus.) 311 08$a981-19-5637-5 320 $aIncludes bibliographical references. 327 $aAntibody-Drug Conjugates Basic Concepts and Structures -- Relationship between target and specific action of antibody-drugs conjugates -- The internalization and therapeutic activity of antibody drug conjugate -- The internalization and intracellular trafficking of ADC -- Distribution and metabolism of antibody-drug conjugates -- Application of Antibody fragments in ADCs -- Novel Targeting Carriers in Antibody-drug Conjugates -- Site-specified Conjugating Technology and Application -- Determination of drug-to-antibody ratio of ADCs -- Pharmacokinetic study of antibody-drug conjugates. 330 $aThis book summarizes the related research achievements in Antibody-drug conjugates (ADCs) and their cell metabolism kinetics. The book has three main parts. The first part describes the basic theory of ADCs, including the basic concept and structure of ADCs, and the relationship between the targets of ADCs and their specific functions. The second part mainly introduces the endocytosis and intracellular metabolism of ADCs, including the relationship between endocytosis and ADC activity, the endocytosis and intracellular transport of ADCs, the distribution and metabolism of ADC in vivo. Then it discusses the new formats and research technology of ADCs, including the application of miniaturized antibodies in ADC synthesis, novel carriers for ADC design, the technology and application of site-specific conjugation, and approaches for analyzing the drug: antibody ratio (DAR), the study of pharmacokinetics of ADCs. This book combines the basic theory with the research technology. It canbe used as a reference book for students, teachers and researchers of biomedical field. 606 $aBiology$xTechnique 606 $aExperimental immunology 606 $aPharmaceutical chemistry 606 $aMedicine$xResearch 606 $aBiology$xResearch 606 $aCytology 606 $aClinical biochemistry 606 $aImmunological Techniques 606 $aPharmaceutics 606 $aBiomedical Research 606 $aCell Biology 606 $aMedical Biochemistry 615 0$aBiology$xTechnique. 615 0$aExperimental immunology. 615 0$aPharmaceutical chemistry. 615 0$aMedicine$xResearch. 615 0$aBiology$xResearch. 615 0$aCytology. 615 0$aClinical biochemistry. 615 14$aImmunological Techniques. 615 24$aPharmaceutics. 615 24$aBiomedical Research. 615 24$aCell Biology. 615 24$aMedical Biochemistry. 676 $a615.36 702 $aChen$b Shuqing 702 $aZhan$b Jinbiao 801 0$bMiAaPQ 801 1$bMiAaPQ 801 2$bMiAaPQ 906 $aBOOK 912 $a9910698647603321 996 $aAntibody-Drug Conjugates and Cellular Metabolic Dynamics$93200507 997 $aUNINA