LEADER 04654nam 2200685 450 001 9910698378103321 005 20230125222019.0 010 $a1-61504-653-4 024 7 $a10.4199/C00105ED1V01Y201403ISP051 035 $a(CKB)2560000000147622 035 $a(EBL)1663908 035 $a(SSID)ssj0001211863 035 $a(PQKBManifestationID)11662671 035 $a(PQKBTitleCode)TC0001211863 035 $a(PQKBWorkID)11206844 035 $a(PQKB)11473774 035 $a(MiAaPQ)EBC1663908 035 $a(CaBNVSL)swl00403317 035 $a(OCoLC)877887404 035 $a(MOCL)201403ISP051 035 $a(OCoLC)170921860 035 $a(EXLCZ)992560000000147622 100 $a20140414h20142014 uy 0 101 0 $aeng 135 $aur|n|---||||| 181 $ctxt 182 $cc 183 $acr 200 10$aErectile dysfunction /$fRany Shamloul, Anthony J. Bella 210 1$a[San Rafael, California] :$cMorgan & Claypool Life Sciences,$d2014. 210 4$dİ2014 215 $a1 online resource (82 p.) 225 1 $aColloquium Series on Integrated Systems Physiology: From Molecule to Function to Disease,$x2154-5626 300 $aPart of: Colloquium digital library of life sciences. 300 $aSeries from website. 311 $a1-61504-652-6 320 $aIncludes bibliographical references. 327 $a1. Anatomy of the penis -- 1.1 Introduction -- 1.1.1 Skin and fascia -- 1.1.2 Tunica albigunea -- 1.1.3 Corpora cavernosa -- 1.1.4 Associated musculature -- 1.1.5 Penile vascular anatomy -- 1.1.6 Lymphatics -- 1.1.7 Innervation -- 1.2 The male urethra -- 1.3 Microscopic anatomy of the penis -- 1.3.1 Tunica albuginea -- 1.3.2 Corpora cavernosa ultrastructure, corpus spongiosum, and glans penis -- 1.3.3 Cavernous smooth muscle -- 327 $a2. General pathophysiology -- 2.1 Dopamine -- 2.2 Oxytocin -- 2.3 Adrenocorticotropic hormones (ACTH) and related peptides -- 2.4 Nitric oxide (NO) -- 2.5 Serotonin -- 2.6 Opioid peptides -- 2.7 Prolactin -- 2.8 Sexual hormones -- 2.9 Control of cavernous smooth muscle function -- 2.9.1 Mechanism of smooth muscle contraction -- 2.9.2 Regulation of VSMC tone -- 2.10 Peripheral neurotransmitters -- 327 $a3. Diabetes and ED -- 3.1 Epidemiologic data -- 3.2 Pathophysiology -- 327 $a4. ED and cardiovascular disease -- 327 $a5. Drugs causing ED -- 5.1 Cardiovascular drugs and erectile function -- 5.2 Antihypertensive treatment and ED -- 5.3 Diuretics -- 5.3.1 [alpha]-adrenoceptor antagonists -- 5.3.2 Ace inhibitor -- 5.3.3 Calcium channel blockers -- 5.3.4 Lipid-lowering drugs (fibrates, statins) -- 5.4 Psychotropic medication -- 5.4.1 Antidepressants -- 5.4.2 Antipsychotics -- 5.5 Other psychotropic medications -- 5.5.1 Anti-androgens -- 327 $aReferences -- Author biographies. 330 3 $aThe understanding of the pathophysiology of erectile dysfunction (ED) has advanced significantly over the past 2 decades. In this ebook, we provide an in-depth analysis of the current knowledge of the pathophysiology of ED in order to provide the reader with an up-to-date and comprehensive understanding of the pathophysiology of ED, which is complex but fascinating. Intensive and intricate mechanisms govern the development of ED. These mechanisms involve complex interaction between vascular, hormonal and neural regulation. Current research on the central regulation of ED is key for the advancement of our understanding of this complex disease. Recent advances in our knowledge of the vascular mechanisms regulating penile erection led to appreciation of ED as an early symptom of cardiovascular disease. Major health concerns such as atherosclerosis, hyperlipidemia, hypertension and diabetes have become well integrated into the investigation of ED. Extensive research on the mechanisms involved in the regulation of penile erection have led to unparalleled advances in the understanding of general vascular regulation. However, many unknowns remain, which provides vast opportunities for future basic and clinical investigations. 410 0$aColloquium series on integrated systems physiology. 606 $aImpotence 606 $aImpotence$xTreatment 615 0$aImpotence. 615 0$aImpotence$xTreatment. 676 $a616.692 700 $aShamloul$b Rany$01352726 702 $aBella$b Anthony J. 712 02$aNational Institute of Diabetes and Digestive and Kidney Diseases (U.S.) 801 0$bMiAaPQ 801 1$bMiAaPQ 801 2$bMiAaPQ 906 $aBOOK 912 $a9910698378103321 996 $aErectile dysfunction$93199417 997 $aUNINA