LEADER 05293nam 2200697Ia 450 001 9910137616703321 005 20200520144314.0 010 $a1-283-59891-4 010 $a9786613911360 010 $a1-118-34287-9 010 $a1-118-34288-7 010 $a1-118-34285-2 035 $a(CKB)3190000000032940 035 $a(EBL)894392 035 $a(OCoLC)815982189 035 $a(SSID)ssj0000711595 035 $a(PQKBManifestationID)11428790 035 $a(PQKBTitleCode)TC0000711595 035 $a(PQKBWorkID)10722054 035 $a(PQKB)10169861 035 $a(MiAaPQ)EBC894392 035 $a(DLC) 2012016148 035 $a(Au-PeEL)EBL894392 035 $a(CaPaEBR)ebr10602101 035 $a(CaONFJC)MIL391136 035 $a(PPN)182402045 035 $a(EXLCZ)993190000000032940 100 $a20120316d2012 uy 0 101 0 $aeng 135 $aur|n|---||||| 181 $ctxt 182 $cc 183 $acr 200 00$aModern tools for the synthesis of complex bioactive molecules$b[electronic resource] /$fedited by Stellios Arseniyadis, Janine Cossy 210 $aHoboken, N.J. $cWiley$dc2012 215 $a1 online resource (600 p.) 300 $aIncludes index. 311 $a0-470-61618-0 320 $aIncludes bibliographical references and index. 327 $aMODERN TOOLS FOR THE SYNTHESIS OF COMPLEX BIOACTIVE MOLECULES; CONTENTS; FOREWORD; PREFACE; CONTRIBUTORS; CHAPTER 1: C-H FUNCTIONALIZATION: A NEW STRATEGY FOR THE SYNTHESIS OF BIOLOGICALLY ACTIVE NATURAL PRODUCTS; 1.1. INTRODUCTION; 1.2. PALLADIUM(0)-CATALYZED INTRAMOLECULAR DIRECT ARYLATION; 1.3. PALLADIUM(0)-CATALYZED INTRAMOLECULAR ALKENYLATION OF sp2 C-H BONDS; 1.4. PALLADIUM(0)-CATALYZED INTRAMOLECULAR ARYLATION OF sp3 C-H BONDS; 1.5. PALLADIUM(II)-MEDIATED INTRAMOLECULAR OXIDATIVE ALKENYLATION OF sp2 C-H BONDS 327 $a1.6. DIRECTING GROUP-ASSISTED PALLADIUM(II)- ENABLED CARBON-CARBON BOND FORMATION AT sp3 C-H BONDS1.7. PLATINUM(II)-MEDIATED ALKANE DEHYDROGENATION; 1.8. PALLADIUM(II)-ENABLED CARBON-OXYGEN BOND FORMATION AT sp3 C-H BONDS; 1.9. IRIDIUM-CATALYZED BORYLATION OF sp2 C-H BONDS; 1.10. RHODIUM(I)-CATALYZED INTRAMOLECULAR DIRECTED ALKYLATION OF sp2 C-H BONDS; 1.11. RHODIUM(III)-CATALYZED SYNTHESIS OF NITROGEN-CONTAINING HETEROCYCLES; 1.12. CONCLUSION; REFERENCES; CHAPTER 2: THE NEGISHI CROSS-COUPLING IN THE SYNTHESIS OF NATURAL PRODUCTS AND BIOACTIVE MOLECULES; 2.1. INTRODUCTION 327 $a2.2. SYNTHESIS OF NATURAL PRODUCTS 2.2.1. Synthesis of Polyenes; 2.2.2. Synthesis of Amino Acids and Macrocyclic Peptides; 2.2.3. Synthesis of Macrocycles; 2.2.4. Synthesis of Small Heterocycles; 2.3. LARGE-SCALE SYNTHESIS OF BIOLOGICALLY ACTIVE MOLECULES; 2.3.1. Nonsteroidal Ligand A-224817.0 1A; 2.3.2. Phosphodiesterase Inhibitor PDE472; 2.3.3. Reverse Transcriptase Inhibitor MIV-150; 2.3.4. B-Raf Kinase Inhibitors; 2.3.5. mGluR1 Antagonist; 2.4. CONCLUSION; REFERENCES; CHAPTER 3: METAL-CATALYZED C-HETEROATOM CROSS-COUPLING REACTIONS; 3.1. GENERAL INTRODUCTION 327 $a3.2. BUCHWALD-HARTWIG-TYPE REACTIONS 3.2.1. Introduction; 3.2.2. Mechanism; 3.2.3. Scope and Limitations; 3.2.4. Applications in the Synthesis of Complex Bioactive Molecules; 3.2.5. C-N Bond Formation; 3.2.6. C-S and C-O Bond Formation; 3.3. ULLMANN-TYPE REACTIONS; 3.3.1. Introduction; 3.3.2. Mechanism; 3.3.3. Scope and Limitations; 3.3.4. Applications in the Synthesis of Complex Bioactive Molecules; 3.3.5. C-N Bond Formation; 3.3.6. C-O Bond Formation; 3.4. MISCELLANEOUS; 3.4.1. Chan-Lam-Evans; 3.4.2. Iron/Copper-Mediated Methodologies; 3.4.3. Other Metals; 3.5. CONCLUSION; REFERENCES 327 $aCHAPTER 4: GOLDEN OPPORTUNITIES IN THE SYNTHESIS OF NATURAL PRODUCTS AND BIOLOGICALLY ACTIVE COMPOUNDS 4.1. INTRODUCTION; 4.2. GOLD-CATALYZED FORMATION OF OXYGEN-CONTAINING HETEROCYCLES; 4.2.1. Cyclizations Leading to Furan and Pyran Derivatives; 4.2.2. Spiroketalizations; 4.2.3. Other Transformations; 4.3. GOLD-CATALYZED FORMATION OF NITROGEN-CONTAINING HETEROCYCLES; 4.3.1. Cyclizations Involving the Formation of a New C-N Bond; 4.3.2. Cyclizations Involving the Formation of a New C-C Bond; 4.4. GOLD-CATALYZED FORMATION OF CARBOCYCLES 327 $a4.4.1. Cyclizations Involving the Formation of a Single New C-C Bond 330 $a"This book provides an overview of the new technologies that have revolutionized organic chemistry and allowed an easy access to very important complex bioactives. 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