LEADER 04806nam 2200649Ia 450 001 9910465455103321 005 20200520144314.0 010 $a1-61761-663-X 035 $a(CKB)2560000000067933 035 $a(EBL)3017942 035 $a(SSID)ssj0000418529 035 $a(PQKBManifestationID)12110292 035 $a(PQKBTitleCode)TC0000418529 035 $a(PQKBWorkID)10377006 035 $a(PQKB)11676927 035 $a(MiAaPQ)EBC3017942 035 $a(Au-PeEL)EBL3017942 035 $a(CaPaEBR)ebr10654913 035 $a(OCoLC)923654443 035 $a(EXLCZ)992560000000067933 100 $a20090930d2010 uy 0 101 0 $aeng 135 $aur|n|---||||| 181 $ctxt 182 $cc 183 $acr 200 00$aGenome instability and transgenerational effects$b[electronic resource] /$fIgor Kovalchuk and Olga Kovalchuk, editors 210 $aNew York $cNova Science Publishers$dc2010 215 $a1 online resource (490 p.) 225 0$aGenetics--research and issues series 300 $aDescription based upon print version of record. 311 $a1-60876-831-7 320 $aIncludes bibliographical references and index. 327 $a""GENOME INSTABILITY AND TRANSGENERATIONAL EFFECTS""; ""GENOME INSTABILITY AND TRANSGENERATIONAL EFFECTS""; ""CONTENTS ""; ""PREFACE ""; ""GENETIC AND EPIGENETIC REGULATION OF TRANSGENERATIONAL CHANGES IN GENOME STABILITY: AN OVERVIEW""; ""REFERENCES ""; ""GENETIC AND EPIGENETIC MECHANISMS ENSURING STABILITY OF MAMMALIAN GENOMES""; ""ABSTRACT ""; ""INTRODUCTION ""; ""GENETIC MECHANISMS OF GENOME STABILITY ""; ""Direct Reversal of Damage ""; ""Base Excision Repair ""; ""Nucleotide Excision Repair ""; ""Mismatch Repair ""; ""Repair of DNA Strand Breaks by Homologous Recombination "" 327 $a""Non-Homologous End Joining """"Cell Cycle Checkpoints ""; ""EPIGENETIC REGULATION OF GENOMIC STABILITY ""; ""DNA Methylation ""; ""Histone Modifications ""; ""Short RNA-Mediated Silencing ""; ""CONCLUSION ""; ""REFERENCES ""; ""GENETIC AND EPIGENETIC REGULATION OF GENOME STABILITY IN PLANTS""; ""ABSTRACT ""; ""INTRODUCTION ""; ""1. ENDOGENOUS AND EXOGENOUS FACTORS THAT AFFECT GENOME STABILITY""; ""1.1. Reactive Oxygen Species Challenge DNA the Repair Machinery and Decrease Genome Stability ""; ""1.2. The Choice of DNA Repair Pathway May Regulate Plant Genome Stability "" 327 $a""1.3. The Importance of Plant Genome Plasticity for Stress Tolerance and Genome Evolution""""2. MECHANISMS AND FUNCTIONS OF EPIGENETIC REGULATIONS IN THE PLANT GENOME ""; ""2.1. DNA Methylation Is a Critical Component in the System of Epigenetic Modifications in Plants""; ""2.2. Histone Modifications and DNA Methylation Are Interdependent ""; ""2.3. Chromatin Remodeling Shapes Chromatin Structure and Complements DNA and Histone Modifications""; ""3. EPIGENETIC MODIFICATIONS a??? A STRESS-RESPONSIVE MECHANISM CONTROLLING GENE REGULATION AND GENOME STABILITY"" 327 $a""3.1. Effects of Stress on Epigenetic Regulations """"3.2. Small RNAs May Direct Epigenetic Modifications to a Specific Genomic Locus""; ""3.2.1. The Complexity and Functional Redundancy of smRNA Biogenesis Pathways in Arabidopsis ""; ""3.2.2. Mechanisms of smRNA-Directed Epigenetic Regulations ""; ""3.2.3. Small RNA Biogenesis is a Sensitive Stress-Responsive System ""; ""4. INDUCIBLE EPIGENETIC CHANGES MAY CHANGE GENOME STABILITY AND GUIDE GENOME EVOLUTION""; ""CONCLUDING REMARKS ""; ""ACKNOWLEDGMENTS ""; ""REFERENCES ""; ""EVOLUTION OF THE FPG/NEI FAMILY OF DNA GLYCOSYLASES "" 327 $a""ABSTRACT """"ABBREVIATIONS ""; ""INTRODUCTION ""; ""METHODS ""; ""EVENTS IN THE FPG/NEI PHYLOGENY ""; ""Horizontal Transfer ""; ""Changes in Substrate Specificity ""; ""Changes in the Structural Zinc-Finger Motif ""; ""Expansion within the Actinobacteria ""; ""THE ENZYMATIC FUNCTION OF THE FPG2 GLADE REMAINS UNKNOWN ""; ""CONCLUSION ""; ""REFERENCES ""; ""STRESS-INDUCED MUTAGENESIS IN BACTERIA ""; ""ABSTRACT ""; ""INTRODUCTION ""; ""STRESSFUL (MUTAGENIC) FACTORS ""; ""STRESS RESPONSE TO ENDOGENOUS AND EXOGENOUS DNA-DAMAGING AGENTS""; ""TRANSLESION DNA SYNTHESIS "" 327 $a""THE GENERAL STRESS RESPONSE "" 410 0$aGenetics - Research and Issues 606 $aEpigenesis 606 $aMutation (Biology) 606 $aVariation (Biology) 608 $aElectronic books. 615 0$aEpigenesis. 615 0$aMutation (Biology) 615 0$aVariation (Biology) 676 $a572.8/77 701 $aKovalchuk$b Igor$0868750 701 $aKovalchuk$b Olga$cMD.$0868751 801 0$bMiAaPQ 801 1$bMiAaPQ 801 2$bMiAaPQ 906 $aBOOK 912 $a9910465455103321 996 $aGenome instability and transgenerational effects$91939293 997 $aUNINA LEADER 01514nam 2200457Ka 450 001 9910695571503321 005 20070130130928.0 035 $a(CKB)5470000002371054 035 $a(OCoLC)80751418 035 $a(EXLCZ)995470000002371054 100 $a20070130d2000 ua 0 101 0 $aeng 181 $ctxt$2rdacontent 182 $cc$2rdamedia 183 $acr$2rdacarrier 200 10$aBOREAS TE-4 branch bag data from boreal tree species$b[electronic resource] /$fJoseph A. 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