LEADER 02633nam 2200361 450 001 9910688587403321 005 20230702121208.0 010 $a3-03897-118-9 035 $a(CKB)5400000000000203 035 $a(NjHacI)995400000000000203 035 $a(EXLCZ)995400000000000203 100 $a20230702d2018 uy 0 101 0 $aeng 135 $aur||||||||||| 181 $ctxt$2rdacontent 182 $cc$2rdamedia 183 $acr$2rdacarrier 200 00$aRoles of NF-?B in Cancer and Their Therapeutic Approaches /$fedited by Ve?ronique Baud 210 1$aBasel :$cMDPI - Multidisciplinary Digital Publishing Institute,$d2018. 215 $a1 online resource (x, 330 pages) 330 $aAlthough mortality rates have declined in recent years, the majority of cancers are still difficult to treat and the medical need for better cancer treatment is evident. The current anticancer armamentarium includes many active agents that are applied across tumor types. However, most of these broadly-active anticancer drugs have a small therapeutic index and barely discriminate between malignant and normal cells. In recent years the focus has shifted to the development of rationally designed, molecularly-targeted therapy for the treatment of a specific cancer, therefore offering the promise of greater specificity coupled with reduced systemic toxicity. NF-kB transcription factor family as emerged as such a promising target for cancer therapy. This Special Issue will explore the routes from NF-kB basic research, cancer research and oncogenomics into the development of NF-kB-based cancer therapeutics and biomarkers. We invite research and review papers in any area of the NF-kB field that are related, but not limited to, fundamental understanding of NF-kB signaling pathways, gene expression profiling, epigenetic regulation, diagnostic, prognostic and pharmacogenomic biomarkers, molecular targets driving the progression of human cancers, cancer drug development on these targets, clinical trial with new agents, and validation in animal models. We hope that this Special Issue reflects the exciting era that we are living in with respect to the field of NF-kB and its applications in cancer research. 606 $aTranscription factors 606 $aProteins$xTherapeutic use 615 0$aTranscription factors. 615 0$aProteins$xTherapeutic use. 676 $a572.8845 702 $aBaud$b Ve?ronique 801 0$bNjHacI 801 1$bNjHacl 906 $aBOOK 912 $a9910688587403321 996 $aRoles of NF-?B in Cancer and Their Therapeutic Approaches$93058547 997 $aUNINA