LEADER 01980nam 2200373 450 001 9910688469103321 005 20230624084725.0 024 7 $a10.5772/intechopen.91512 035 $a(CKB)5400000000043846 035 $a(NjHacI)995400000000043846 035 $a(EXLCZ)995400000000043846 100 $a20230624d2021 uy 0 101 0 $aeng 135 $aur||||||||||| 181 $ctxt$2rdacontent 182 $cc$2rdamedia 183 $acr$2rdacarrier 200 00$aAdvances in Hepatology /$fedited by Luis Rodrigo [and three others] 210 1$aLondon, England :$cIntechOpen,$d2021. 215 $a1 online resource (258 pages) 311 $a1-83968-625-1 330 $aThis book discusses clinical advances in hepatology, with a focus on metabolic diseases and chronic hepatitis C. The development of direct-acting antiviral (DAA) agents for the treatment of hepatitis C virus (HCV) infection in 2010 has completely transformed the management of this disease. This transformative nature of DAA therapy underpins the goal of the World Health Organization (WHO) to eliminate HCV infection as a public health threat by 2030. The advantages of using these therapies include high efficacy (sustained virological response rate >95%) with minimal side effects, good tolerability, easy drug administration (once-daily oral dosing) and short duration of treatment (8-12 weeks). The commercialization of second-generation DAA agents due to their high effectiveness, few side-effects and pangenotypic action. This transformative nature of DAA therapy underpins the goal of the WHO to eliminate HCV infection as a public health threat by 2030. 606 $aHepatology 606 $aLiver$xDiseases 615 0$aHepatology. 615 0$aLiver$xDiseases. 676 $a616.362 702 $aRodrigo$b Luis 801 0$bNjHacI 801 1$bNjHacl 906 $aBOOK 912 $a9910688469103321 996 $aAdvances in hepatology$92239718 997 $aUNINA