LEADER 02315nam 2200361 450 001 9910688414503321 005 20230629071438.0 024 7 $a10.3390/books978-3-03842-822-0 035 $a(CKB)5400000000040417 035 $a(NjHacI)995400000000040417 035 $a(EXLCZ)995400000000040417 100 $a20230629d2018 uy 0 101 0 $aeng 135 $aur||||||||||| 181 $ctxt$2rdacontent 182 $cc$2rdamedia 183 $acr$2rdacarrier 200 10$aZinc Signaling in Physiology and Pathogenesis /$fToshiyuki Fukada, Taiho Kambe 210 1$aBasel :$cMDPI - Multidisciplinary Digital Publishing Institute,$d2018. 215 $a1 online resource (ix, 279 pages) $cillustrations 311 $a3-03842-822-1 330 $aThe essential trace element zinc plays indispensable roles in multiple cellular processes. It regulates a great number of protein functions, including transcription factors, enzymes, adapters, and growth factors as a structural and/or catalytic factor. Recent studies have highlighted another function of zinc as an intra- and intercellular signaling mediator, which became recognized as the "zinc signal". Indeed, zinc regulates cellular signaling pathways, which enable conversion of extracellular stimuli to intracellular signals, and controls various intracellular and extracellular events, and thus zinc mediates communication between cells. The zinc signal is essential for physiology, and its dysregulation causes a variety of diseases, such as diabetes, cancer, osteoarthritis, dermatitis, and dementia. This Special Issue focuses on crucial roles of zinc signaling in biological processes in molecular and physiological basis, addressing the future directions and questions underlying this unique phenomenon. Because there is growing interest and attention in physiopathological contribution of zinc signal, we believe this Special Issue will provide very timely information on it and thus should appeal to a wide range of readers. 606 $aZinc 615 0$aZinc. 676 $a669.5 700 $aFukada$b Toshiyuki$01368763 702 $aKambe$b Taiho 801 0$bNjHacI 801 1$bNjHacl 906 $aBOOK 912 $a9910688414503321 996 $aZinc Signaling in Physiology and Pathogenesis$93394728 997 $aUNINA