LEADER 03898nam 2200625 450 001 9910688229903321 005 20230621135807.0 010 $a9782889195398 (ebook) 035 $a(CKB)3710000000569665 035 $a(SSID)ssj0001680118 035 $a(PQKBManifestationID)16496010 035 $a(PQKBTitleCode)TC0001680118 035 $a(PQKBWorkID)15028359 035 $a(PQKB)11228372 035 $a(WaSeSS)IndRDA00057277 035 $a(oapen)https://directory.doabooks.org/handle/20.500.12854/45300 035 $a(EXLCZ)993710000000569665 100 $a20160829d2015 uy | 101 0 $aeng 135 $aur||||||||||| 181 $ctxt 182 $cc 183 $acr 200 00$aDiverse functions of mucosal resident memory T cells$b[electronic resource] /$fedited by Kimberly Sue Schluns and Kim Klonowski 210 $cFrontiers Media SA$d2015 210 31$aFrance :$cFrontiers Media SA,$d2015 215 $a1 online resource (86 pages) $ccolour illustrations, charts 225 0 $aFrontiers Research Topics 300 $aBibliographic Level Mode of Issuance: Monograph 320 $aIncludes bibliographical references. 330 $aEarly studies recognized the unique phenotype and attributes of T cells found in mucosal tissues, such as the intestines, skin, lung and female reproductive tract. This special topic issue will cover many aspects of mucosal-resident T cell biology during infection and disease and is dedicated to Leo Lefrancois, a pioneer in this field who recently passed away. A major proportion of these mucosal T cells are memory T cells, now recognized as a major constituent of memory T cells referred to as tissue-resident memory T cells. Unlike central and effector memory T cell subsets, tissue-resident memory T cells exhibit tissue specificity with minimal systemic migration. Nonetheless, tissue-resident memory T cells share a similar origin and display some overlapping phenotypes with their other memory T cell counterparts. Articles in this issue will describe the different types of memory T cells residing in mucosal tissues, their origins and functions as well as how they vary among discrete mucosal sites. Manuscripts will consider the unique physiological environments and cellular constituents which facilitate tissue residency while preserving tissue function. Additionally, there will be descriptions of the various mechanisms responsible for the migration and segregation of tissue resident memory CD8 T cells from the peripheral T cell pool. Although the mechanisms facilitating the sequestration of tissue-resident memory T cells within a respective tissue has not well characterized, various theories will also be discussed. Lastly, how these T cells contribute to immunity to pathogens, cancer, and autoimmunity and could be modified through vaccination or therapeutic intervention will be described. As mucosal tissues are the major portals of pathogen entry and frequent transformation, the activities and persistence of tissue resident memory T cells is crucial for mediating protection at these sites. 606 $aMicrobiology & Immunology$2HILCC 606 $aBiology$2HILCC 606 $aHealth & Biological Sciences$2HILCC 610 $apathogens 610 $aMicroscopy 610 $aMigration 610 $aMucosa 610 $aT cell differentiation 610 $aVaccination 610 $aInflammation 610 $aEpithelium 610 $aCD103 615 7$aMicrobiology & Immunology 615 7$aBiology 615 7$aHealth & Biological Sciences 676 $a616.07/9 700 $aKimberly Sue Schluns$4auth$01352873 702 $aSchluns$b Kimberly Sue 702 $aKlonowski$b Kim 801 0$bPQKB 801 2$bUkMaJRU 912 $a9910688229903321 996 $aDiverse functions of mucosal resident memory T cells$93205426 997 $aUNINA