LEADER 01945nam 2200385 450 001 9910688208303321 005 20230625095934.0 035 $a(CKB)5400000000045552 035 $a(NjHacI)995400000000045552 035 $a(EXLCZ)995400000000045552 100 $a20230625d2021 uy 0 101 0 $aeng 135 $aur||||||||||| 181 $ctxt$2rdacontent 182 $cc$2rdamedia 183 $acr$2rdacarrier 200 00$aMuscle cell and tissue $enovel molecular targets and current advances /$fedited by Kunihiro Sakuma, Nobuo Morotomi 210 1$aLondon :$cIntechOpen,$d[2021] 210 4$dİ2021 215 $a1 online resource (130 pages) $cillustrations 311 $a1-83968-652-9 320 $aIncludes bibliographical references. 330 $aThe loss of skeletal muscle mass and strength substantially impairs physical performance and quality of life. This book details some approaches to the treatment of muscle wasting. It also reviews novel applications against pulmonary arterial hypertension such as cell reprogramming and the use of anticancer drugs that induce programmed cell death. Vascular smooth muscle cells (VSMCs) are the most prevalent cell types in blood vessels and serve critical regulatory roles. This publication also introduces mathematical models concerning the molecular mechanism and targets of cyclic guanosine 3',5'-monophosphate (cGMP) in the contraction of VSMCs. This book will be of interest to professionals in clinical practice, medical and health care students, and researchers working in muscle-related fields of science. 517 $aMuscle Cell and Tissue 606 $aMuscles$xDiseases 615 0$aMuscles$xDiseases. 676 $a616.74 702 $aSakuma$b Kunihiro 702 $aMorotomi$b Nobuo 801 0$bNjHacI 801 1$bNjHacl 906 $aBOOK 912 $a9910688208303321 996 $aMuscle Cell and Tissue$92280361 997 $aUNINA