LEADER 04637nam 2200397 450 001 9910688199003321 005 20230701234053.0 035 $a(CKB)5580000000514282 035 $a(NjHacI)995580000000514282 035 $a(EXLCZ)995580000000514282 100 $a20230701d2022 uy 0 101 0 $aeng 135 $aur||||||||||| 181 $ctxt$2rdacontent 182 $cc$2rdamedia 183 $acr$2rdacarrier 200 00$aChagas Disease $efrom cellular and molecular aspects of trypanosoma cruzi-host interactions to the clinical intervention /$fedited by Rubem Menna-Barreto 210 1$aLondon :$cIntechOpen,$d2022. 210 4$dİ2022 215 $a1 online resource (ix, 266 pages) $cillustrations 311 $a1-80355-692-7 320 $aIncludes bibliographical references. 327 $aPreface -- Section 1 The State of Art -- Chapter 1 Introductory Chapter: Chagas Disease -- A Multidisciplinary Old Public Health Problem by Rubem Menna-Barreto -- Section 2 The Treatment -- Chapter 2 New Therapeutics for Chagas Disease: Charting a Course to Drug Approval by Anthony Man and Florencia Segal -- Chapter 3 The Saga of Selenium Treatment Investigation in Chagas Disease Cardiopathy: Translational Research in a Neglected Tropical Disease in Brazil by Tania C. de Araujo-Jorge, Anna Cristina C. Carvalho, Roberto R. Ferreira, Luciana R. Garzoni, Beatriz M.S. Gonzaga, Marcelo T. Holanda, Gilberto M. Sperandio da Silva, Maria da Gloria Bonecini-Almeida, Mauro F.F. Mediano, Roberto M. Saraiva and Alejandro M. Hasslocher-Moreno -- Chapter 4 Translational Research on Chagas Disease: Focusing on Drug Combination and Repositioning by Marcos Andre? Vannier-Santos, Ana Ma?rcia Suarez-Fontes, Juliana Almeida-Silva, Alessandra Lifsitch Vic?osa, Sandra Aurora Chavez Perez, Alejandro Marcel Hasslocher-Moreno, Gabriel Parreiras Estolano da Silveira, Luciana Fernandes Portela and Roberto Magalha?es Saraiva -- Section 3 The Pathogenesis -- Chapter 5 Digestive Disorders in Chagas Disease: Megaesophagus and Chagasic Megacolon by Vi?ctor Hugo Garci?a Orozco, Juan Enrique Villalvazo Navarro, Carlos Solar Aguirre, Carlos Manuel Ibarra Ocampo, Ce?sar Iva?n Di?az Sandoval, Carlos Alejandro Orti?z Gallegos, Diego Javier Oregel Camacho and Araceli Noriega Bucio -- Chapter 6 How Do Mouse Strains and Inoculation Routes Influence the Course of Experimental Trypanosoma cruzi Infection? by Fla?via de Oliveira Cardoso, Carolina Salles Domingues, Ta?nia Zaverucha do Valle and Ka?tia da Silva Calabrese -- Chapter 7 Modulation of Host Cell Apoptosis by Trypanosoma cruzi: Repercussions in the Development of Chronic Chagasic Cardiomyopathy by Fiordaliso Carolina Roma?n-Carraro, Diego Maurizio Coria-Paredes, Arturo A. Wilkins-Rodri?guez and Laila Gutie?rrez-Kobeh -- Chapter 8 Evaluation of Molecular Variability of Isolates of Trypanosoma cruzi in the State of Rio de Janeiro-Brazil by Helena Keiko Toma, Luciana Reboredo de Oliveira da Silva, Teresa Cristina Monte Gonc?alves, Renato da Silva Junior and Jacenir R. Santos-Mallet. 330 $aEven 110 years after its discovery, Chagas disease is still an important public health problem, especially in Latin America where it is endemic. The limited effect of current treatments in the chronic phase of the disease, as well as the lack of information about disease progression, are crucial challenges that justify the intense research on this illness. The interaction between the etiological agent Trypanosoma cruzi and its invertebrate and vertebrate hosts involves the regulation of the parasite virulence and host immune responses. T. cruzi presents mechanisms to evade host defenses, including resistance to oxidative species and vesicles secretion, among many others. In this context, a better understanding of the biochemical and molecular features of the parasite's success inside its hosts could contribute to the development of novel anti-T. cruzi strategies such as prototypes of drugs and vaccines. This book discusses Chagas disease and its etiological agent, including information on relevant clinical aspects such as diagnosis, treatment, biomarkers, and so on. It also presents information about cellular, molecular, and biochemical characteristics of the parasite-host interactions. 606 $aChagas' disease 606 $aTrypanosoma cruzi 615 0$aChagas' disease. 615 0$aTrypanosoma cruzi. 676 $a616.9363 702 $aMenna-Barreto$b Rubem 801 0$bNjHacI 801 1$bNjHacl 906 $aBOOK 912 $a9910688199003321 996 $aChagas Disease$91994004 997 $aUNINA