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101 0 $aeng
135   $aur|||||||||||
181   $ctxt$2rdacontent
182   $cc$2rdamedia
183   $acr$2rdacarrier
200 00$aMutagenesis and Mitochondrial-Associated Pathologies /$fMichael Fasullo, Angel Catala, editors
210  1$aLondon :$cIntechOpen,$d2022.
215   $a1 online resource (116 pages)
311   $a1-80355-173-9 
330   $aReactive oxygen species (ROS) and DNA double-strand breaks can result from mitochondrial defects and external sources, such as ionizing radiation. If not repaired properly, pathogenic mutations are generated. Human diseases resulting from inherited mitochondrial defects manifest in organs that physiologically require a high level of ATP synthesis. These diseases are clinically challenging, but new experimental clinical therapies include gene editing and mitochondrial transplants. Pathogenic ROS-associated cellular damage includes DNA double-strand breaks, and mouse models are now available to study multiple repair pathways. This book discusses the clinical manifestations of mitochondrial diseases in both the eye and the kidney, and presents new insights into double-strand break repair pathways and developmental phenotypes of g-ray-associated ontogenic mutations of Drosophila melanogaste.
606   $aDNA damage
606   $aMutagenicity testing
615  0$aDNA damage.
615  0$aMutagenicity testing.
676   $a616.042
702   $aCatala$b Angel
702   $aFasullo$b Michael
801  0$bNjHacI
801  1$bNjHacl
906   $aBOOK
912   $a9910688183903321
996   $aMutagenesis and Mitochondrial-Associated Pathologies$92903154
997   $aUNINA