LEADER 00747nam0 22002411i 450 001 990006386410403321 005 19980601 035 $a000638641 035 $aFED01000638641 035 $a(Aleph)000638641FED01 035 $a000638641 100 $a19980601d1993----km-y0itay50------ba 105 $a--------00-yy 200 1 $aPOLIS$eCollana dell'istituto dell'Azione Cattolica Italiana per lo studio dei problemi sociali e politici "Vittorio Bachelet" 210 $aRoma$cA.V.E.$d1993 801 0$aIT$bUNINA$gRICA$2UNIMARC 901 $aBK 912 $a990006386410403321 951 $aII D 166$bV. SCHEDONE$eBiblioteca Centrale della Facoltą di Giurisprudenza$fFGBC 959 $aFGBC 996 $aPolis$961689 997 $aUNINA DB $aGIU01 LEADER 02319nam 2200337 450 001 9910687978203321 005 20230625195734.0 035 $a(CKB)5410000000364667 035 $a(NjHacI)995410000000364667 035 $a(EXLCZ)995410000000364667 100 $a20230625d2019 uy 0 101 0 $aeng 135 $aur||||||||||| 181 $ctxt$2rdacontent 182 $cc$2rdamedia 183 $acr$2rdacarrier 200 00$aBiology of Trypanosoma cruzi /$fedited by Wanderley de Souza 210 1$aLondon :$cIntechOpen,$d2019. 215 $a1 online resource (234 pages) 311 $a1-83968-205-1 330 $aTrypanosoma cruzi, an important zoonotic protozoan that causes Chagas disease, affects at least 8 million people in Latin America. Chagas disease is an important life-long infection in humans that can be divided into distinct clinical stages: the acute phase, where patient symptoms can vary from asymptomatic to severe; the indeterminate form, which is usually asymptomatic; and the chronic phase, where cardiomyopathy and/or digestive megasyndromes appear. In addition to its medical importance, T. cruzi is an interesting biological model for studying processes such as: (1) cell differentiation, where a non-infective stage transforms into an infective one; (2) cell invasion, where the infective stages are able to penetrate into a mammalian host cell, where they multiply several times and thus amplify the infection; and (3) evasion from the immune system, using several mechanisms. This book, with 13 chapters, has been organized in four major sections: 1. "Basic Biology," 2. "Biochemistry and Molecular Biology," 3. "Parasite"Host Cell Interaction," and 4 "Chemotherapy." The chapters include basic biological information on the protozoan lifecycle, including new information on parasite genomics and proteomics. In addition, they analyze the interaction with host cells as well the immune response and evasion, ending with information on experimental chemotherapy against Chagas disease. 606 $aTrypanosoma cruzi 615 0$aTrypanosoma cruzi. 676 $a593.18 702 $aSouza$b Wanderley de 801 0$bNjHacI 801 1$bNjHacl 906 $aBOOK 912 $a9910687978203321 996 $aBiology of Trypanosoma cruzi$92135863 997 $aUNINA