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024 7 $a10.5772/intechopen.92915
035   $a(CKB)5850000000050229
035   $a(NjHacI)995850000000050229
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100   $a20230627d2022      uy             0
101 0 $aeng
135   $aur|||||||||||
181   $ctxt$2rdacontent
182   $cc$2rdamedia
183   $acr$2rdacarrier
200 00$aRegulation and Dysfunction of Apoptosis /$fYusuf Tutar, editor
210  1$aLondon :$cIntechOpen,$d2022.
215   $a1 online resource (182 pages)
311   $a1-83969-195-6 
330   $aThe book provides a comprehensive review of apoptotic cell death. It discusses the mechanism of apoptosis and emerging principles of drug resistance in cancer. The development of novel drug targets and drug delivery systems for inhibiting or inducing apoptosis are the ultimate goal. Further, upregulation of anti-apoptotic proteins and loss of pro-apoptotic proteins strongly favors apoptosis evasion. The ability of cancer cells to evade apoptosis is critical for the progression and clonal expansion of malignantly transformed cells. Defective apoptosis imparts proliferative advantage to cancer cells or cells with the potential to become cancerous. The mechanisms employed by cancer cells to evade apoptosis can be used in the strategic design of therapeutic regimens aimed at exploiting apoptotic signaling networks to ensure tumor-specific cell death. This book presents knowledge of the molecular mechanisms of defective apoptosis that could be translated into the development of novel therapeutic agents and therapeutic modalities for cancer treatment.
606   $aCell death
606   $aApoptosis
615  0$aCell death.
615  0$aApoptosis.
676   $a571.936
702   $aTutar$b Yusuf
801  0$bNjHacI
801  1$bNjHacl
906   $aBOOK
912   $a9910687977203321
996   $aRegulation and Dysfunction of Apoptosis$92902631
997   $aUNINA